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Consulate
Left: Stephanie Bruce, Consul General of the United States in South Africa Right: Prof Hester C. Klopper, Vice-Chancellor and Principal of the University of the Free State

The University of the Free State (UFS) recently had the honour of hosting Stephanie Bunce, Consul General of the United States (US) in South Africa, and her delegation on the Bloemfontein Campus. The visit came at a significant moment, shortly after the first 100 days of Prof Hester C. Klopper’s tenure as Vice-Chancellor and Principal. 

The meeting marked an important introduction between two leaders new in their respective roles: Prof Klopper at the UFS, and Consul General Bunce, who began her posting in Johannesburg in September 2024. Their discussions offered an opportunity to align the strategic ambitions of the UFS with the priorities of the U.S Mission in South Africa, while reflecting on the longstanding and fruitful relationship between the UFS and American universities. 

Consul General Bunce commended the depth of UFS’s academic partnerships with the United States and expressed enthusiasm about the university’s future direction. “I’m really excited to hear what you’re looking for in the next few years and how we can continue to work together,” she said.

 

Advancing clinical training and collaboration 

The delegation toured the world-class Clinical Simulation and Skills Unit (CSSU), where Prof Mathys Labuschagne, Head of Clinical Simulation and Skills Unit, School of Biomedical Sciences, and his team showcased how advanced simulation technologies prepare students for clinical practice. “Hands-on practice in a safe, non-threatening environment is one of the best ways to build confidence and skills,” explained Prof Labuschagne. 

The CSSU was developed based on a model from Penn State University following a visit 15 years ago - a collaboration that has continued to thrive. “Collaboration with US universities opens doors for joint teaching, student exchanges, and research partnerships that drive innovation,” Prof Labuschagne added. 

 

Deepening a century of partnership 

Collaboration between the UFS and the U.S universities dates back more than a century. In the 1920s, the University of Michigan established the Lamont-Hussey Observatory on Naval Hill, and Harvard University relocated the Boyden Observatory to Maselspoort. Both observatories, now part of the UFS, symbolise a legacy of shared scientific discovery. 

These historic ties have since evolved into formal agreements with universities across the United States. Between 2020 and 2024, the US was the leading country collaborating with the UFS, producing more than 929 co-authored publications across 648 institutions. Today, partnerships continue to expand through research, academic exchanges, and staff mobility programmes that leave a lasting impact on students and society alike. 

Consul General Bunce highlighted the distinctive nature of these partnerships. “In many countries, academic exchange is driven by government. Here, it grows organically from strong relationships and programmes.”

Prof Lynette Jacobs, interim Director in the Office for International Affairs, emphasised the value of these ties: “Our partnership with the United States shows how a strong and mature relationship can drive diversified internationalisation, advancing our strategic goal of global engagement with real impact. We look forward to welcoming the Consul General on our other two campuses.”   

 

Driving innovation and commercialisation

In her address, Prof Klopper outlined the university’s vision to translate research into real-world solutions and commercial opportunities. “The UFS is learning from many American universities’ innovative models, which leverage multiple income streams and strong industry partnerships,” noted Prof Klopper. Prof Klopper emphasised that diversifying income is not only about sustainability but also about ensuring research has impact. Recent spin-off companies are an example of this vision becoming reality. 

 

Charting the future 

The US delegation expressed strong interest in UFS’s areas of strength, including community engagement, entrepreneurship, and student success initiatives. They also highlighted the potential for US students to study at the UFS, with consular support services in place to assist visiting students in emergencies. 

“It is wonderful to see relationships that grow and change but continue to bring in new partnerships and exchanges,” Consul General Bunce remarked. 

With plans for new mobility schemes, joint research projects, and a shared commitment to innovation, the UFS and its US partners are well-positioned to shape the next chapter in their century-long story of collaboration.  

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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