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10 June 2019 | Story Lacea Loader

The executive committee of the University of the Free State (UFS) has today resumed the training of its undergraduate students in the School of Clinical Medicine at the Pelonomi Hospital in Bloemfontein with immediate effect.

The decision to suspend the training of undergraduate students at the hospital came after the attempted rape of a medical intern last week, as well as the robbery of a medical officer in the parking area of the hospital over the weekend.

This morning, discussions involving the university management, the Head of the Department of Health (DoH) in the Free State Province, the executive committee of the Pelonomi Hospital, and the South African Police Service (SAPS) took place regarding the security situation at the hospital. The DoH provided the university with a security project plan comprising immediate and medium-term interventions, and a commitment to execute the plan as a matter of urgency. The university’s executive management furthermore met with the management of the Faculty of Health Sciences and, based on a safety risk assessment, the university’s executive management agreed that undergraduate students could again fully access the clinical platform at Pelonomi Hospital.

Interventions in the security project plan include the installation of high-mast lights in the precinct of the hospital, reparation of the perimeter fence, security locks, and limiting access to the hospital and the hospital grounds after 20:00 until 06:00. A Venue Operation Centre (VOC) made up of SAPS, institutional security management, and the Community Policing Forum will also be established at the hospital.

“The main focus and concern for the executive management of the university is the safety of its students and staff. We are satisfied with the security plan and the overall interventions committed to by the DoH and will monitor the implementation of these interventions with the management of the Pelonomi Hospital and the DoH. The security interventions will alleviate the situation at the hospital in order for the university to continue sending its undergraduate students there for training,” said Prof Francis Petersen, UFS Rector and Vice-Chancellor, during a media briefing today.

Prof Petersen also met with undergraduate students in the Schools of Clinical Medicine, Nursing, and Allied Health Professions today to discuss the situation at the hospital. Trauma counselling is provided to undergraduate students and staff and those in need of counselling at the Pelonomi Hospital.

The DoH has furthermore extended its bus service between the clinical platforms in Bloemfontein to students in need of transport of the School of Clinical Medicine according to time slots as from the beginning of the second semester. This service will ultimately be extended to undergraduate students in the Schools of Nursing and Allied Health Professions. “We will also look into further transport solutions for the longer term for our students,” said Prof Petersen.

Undergraduate students from the university’s Schools of Clinical Medicine, Nursing, and Allied Health Professions are trained on the clinical platforms in Bloemfontein – these include the Pelonomi Hospital, Universitas Hospital, National Hospital, the Mangaung University Community Partnership Programme (MUCPP), and the Free State Psychiatric Complex.

Although these clinical training platforms are under the jurisdiction of the DoH in the Free State Province, they form a critical part of the training of undergraduate students in the university’s Faculty of Health Sciences. Staff on the joint establishment of the UFS and the DoH also work at hospitals on the clinical platforms.

Released by:
Lacea Loader (Director: Department of Communication and Marketing)
Telephone: +27 51 401 2584 | +27 83 645 2454
E-mail: news@ufs.ac.za | loaderl@ufs.ac.za


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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