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31 March 2020 | Story Leonie Bolleurs | Photo Gerhard de Jager
Prof Linda Basson recently returned from a three-month research expedition in Antarctica. Here she is, relaxing on the ice with the ever-inquisitive Adelie penguins having a gander at these strangers in their snowy world.
Prof Linda Basson recently returned from a three-month research expedition in Antarctica. Here she is, relaxing on the ice with the ever-inquisitive Adelie penguins having a gander at these strangers in their snowy world.

Very little is known about the parasites of Antarctica, which is a highly productive part of the oceans. These small organisms can be used very successfully to determine the health of this fragile ecosystem.

“Our research data can make significant contributions to the biodiversity of parasites, for a start. The data can also be very valuable to indicate the overall health of this large ecosystem – an ecosystem that drives many of the life-giving processes on our planet.” This is the belief of Prof Linda Basson from the Department of Zoology and Entomology at the University of the Free State (UFS). 

She is an aquatic parasitologist who concentrates on various parasites from a wide range of hosts, including vertebrates (fish and amphibians) and invertebrates (plankton, urchins, starfish, sea cucumbers and red-bait).

Prof Basson, together with PhD student Gerhard de Jager, was invited by Prof Isabelle Ansorge, Head of the School of Oceanography, University of Cape Town, to join her research team on the South African National Antarctic Programme (SANAE) Voyage 59 to Antarctica. 

Widen the scope of research 
“Our aim on this trip was to determine how we can collaborate with the various oceanographers to widen the scope of research normally performed on these voyages, in order to also include parasitological aspects. Once we arrived on the continent of Antarctica, we worked to collect a range of hosts from the Southern Ocean to screen these for the whole array of parasites,” she explains. 

No research of any kind on aquatic parasites has ever been done in Penguin Bukta and Akta Bukta, the specific areas where Prof Basson was based with other scientists and the rest of the Agulhas crew.

She adds: “Our research will contribute to the wider knowledge of parasites in marine environments, but specifically in this area where little to nothing is known.”

A chance of a lifetime 
“Antarctica was literally one of the top research destinations on my bucket list. Travelling to and working in Antarctica is a lifelong dream of mine. It was a chance of a lifetime that I could not miss out on,” says Prof Basson. 

Sharing her experience, she says a typical day on board the SA Agulhas II in Antarctica will start with a cup of good, quality coffee and a look at the prevailing weather on the stern of the ship. 

“One would always be amazed by the beautiful, ceaselessly changing water, the restless sea ice and the impressive ancient ice shelf in very invigorating temperatures, while an ethereal Snow Petrel swirls past and the occasional Adelie penguin comes to gaze and contemplate the presence of this large red structure floating in their habitat and obscuring their view. After tearing yourself away from this, the rest of the day would be spent either in the well-equipped laboratory working through collected samples, or else planning the next exciting collection in the intensely cold water.”

Remarkable journey 
To eternalise memories of this unique experience of almost three months, Prof Basson says that, “One cannot go without a fully charged camera with a large SD card, ready to capture the many facets of this exceedingly fragile but enchanting world of ice and sky, ever changing and all in innumerable shades of white”.

“This truly remarkable journey will forever be associated with a myriad of brilliant highlights.”

Finding it extremely difficult to single out a specific highlight, she listed a long list of memorable events, but as a scientist she will always remember “realising the wealth and cornucopia of microscopic life present in the southernmost of our oceans and seeing this first-hand under the microscope”.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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