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31 March 2020 | Story Leonie Bolleurs | Photo Supplied
UFS Covid-19 vaccine research team
Prof Robert Bragg and members of the Veterinary Biotechnology research group believe that finding a vaccine for COVID-19 will not be a ‘quick fix’. From the left are: Prof Bragg, Samantha McCarlie, Liese Kilian, and Dr Charlotte Boucher-van Jaarsveld. The photo was taken during the World Veterinary Poultry Association congress in Thailand in 2019.

On 31 March 2020, there were 804 061 coronavirus cases and 39 064 deaths globally due to the outbreak. According to media reports, there is still no licensed vaccine for COVID-2019 – the cause of our current global health emergency.  

Prof Robert Bragg, researcher at the University of the Free State (UFS), says this is without a doubt the most pressing research need in the world today. 

The Veterinary Biotechnology research group in the Department of Microbial, Biochemical, and Food Biotechnology at the UFS recently submitted an article for publication on the design of a possible COVID-19 vaccine, based on work they have done on infectious bronchitis virus (also a coronavirus). The article, authored by the group of which Prof Bragg is a member, is titled: A sub-unit vaccine produced in 'Yarrowia lipolytica' against COVID-19: Lessons learnt from infectious bronchitis virus. 

The research group, consisting of researchers and postgraduate students, is mostly looking at strategies for improved disease control, mainly in avian species, through vaccine development, treatment, and biosecurity.

Prof Bragg says their main aim with this study was to get the research out there so that the bigger pharmaceutical companies could take up the design of a possible COVID-19 vaccine and assist with the development of a vaccine. 

He says the research group’s role in this lengthy process would be to express the protein, which could be used in the development of a possible vaccine. “Thereafter, it will have to be taken up by a vaccine manufacturer to get the vaccine made and to the market.”

Developing a vaccine
Liese Kilian, a member of the research group, finished writing up her MSc thesis in Microbiology in the UFS Department of Microbial, Biochemical, and Food Biotechnology in December 2019 – the same time that COVID-19 originated in China. She has been working on the development of an edible sub-unit vaccine against the infectious bronchitis virus (IBV), which is a widespread avian coronavirus. This virus is specific to poultry and is different from COVID-19. 

Kilian’s project was conducted under the supervision of Prof Bragg and Dr Charlotte Boucher-van Jaarsveld. Dr Boucher-van Jaarsveld is a research fellow in the university’s Department of Microbial, Biochemical and Food Biotechnology.

Kilian, with the assistance of Samantha Mc Carlie, currently a master’s student in the research group, substituted the genetic code of the IBV with the genetic code of the COVID-19 virus, which were already published at that stage. Thus, a gene for the development of a possible sub-unit vaccine against the S1 spike protein of COVID-19 was developed for expression in the same yeast strain used to express the spike protein of IBV. A sub-unit vaccine can be described as part of a pathogen, triggering an immune response against the pathogen from which it is derived.

After Killian successfully developed the gene for this study, she expressed the S1 spike protein of the IBV in a yeast-based expression system developed by the research group. Dr Boucher-van Jaarsveld says this simply means that the yeast takes up the foreign genetic material (viral gene) into its own genetic make-up and makes more of this protein as if it is part of the yeast’s normal material. 

“The images of COVID-19 are being shown constantly in the media and the ‘spikes’ can be seen on all of these images. These spikes are very typical for all coronaviruses and there is some level of similarity between the structure of these spikes in many of the coronaviruses,” Prof Bragg adds.

According to the World Health Organisation, the spike protein is a promising candidate for a sub-unit vaccine due to its immunogenicity and safety, as well as manufacturing and stability considerations during large-scale development.

Prof Bragg says there are many different expression systems that are widely used. Producing the sub-unit vaccine in a yeast species is beneficial for the work they are doing. A yeast expression system is favourable as large-scale production, is less expensive compared to mammalian cell lines, and can be applied as an edible vaccine.

“The technology to grow massive volumes of yeast are also very well established. This, after all, is how beer is made!” Prof Bragg says. Dr Boucher-van Jaarsveld adds: “The expression of an antigen is not necessarily just geared towards vaccines but can also be used in the development of diagnostic tests to screen populations for infections.”

Working with other researchers
“Now that the situation is all but out of control, we maybe need to investigate the possibilities of working with other key researchers at the UFS as well as other universities in South Africa to develop the vaccine or diagnostic reagents locally. Discussions on this aspect are already underway.”

Several other universities in South Africa are also working to find a cure for the virus. Government availed funding for more research on the matter. According to Higher Education, Science and Technology Minister, Blade Nzimande, the University of Cape Town, the Council for Scientific and Industrial Research, as well as the Vaccines Institute of Southern Africa are working on the development of a vaccine.

Prof Bragg expressed the hope of obtaining funding for this work. “Because without funding, we will not be able to do anything with this data,” he says. They are currently investigating different funding options. 

“The sooner we start on the development of a vaccine, the sooner there will be one, but it will not be a ‘quick fix’. It must be stressed that, even if vaccine development is fast-tracked through the regulatory bodies, it will take many months (if not years) to move from the laboratory to the first human experimentation. It will take even longer before any human vaccine can be rolled out,” says Prof Bragg.



News Archive

UFS presents first Beyers Naudé Memorial lecture
2010-09-16

At the Beyers Naudé   Memorial lecture were, from the left: Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS; Rev. Cedric Mayson; and Mr Kgotso Schoeman, Chief Executive Officer of Kagiso Trust.
Photo: Dries Myburg

The seventh Beyers Naudé Memorial lecture was presented for the first time at the University of the Free State (UFS) this week. This lecture that is presented at a different university each year took place on the Main Campus of the UFS in Bloemfontein this year. Rev. Cedrick Mayson presented the lecture with under the theme: Crafting a legacy.

According to Rev. Mayson more deeply rooted forms of suppression came forward after the democratic elections in 1994. Liberation from apartheid was, according to Mason, very superficial. The poor were still severely suppressed at economic, political, cultural, religious and environmental level. “We have to apply Beyers Naudé’s legacy of liberation in these areas,” Rev. Mayson declared.

“The system according to which the rich become wealthier and the poor become poorer must be replaced by a system where everybody can have enough. This is only possible with the insight of the oppressed.

“The government and the opposition are dominated by people who seek advantage for their own gain. Regardless of democratic slogans and some enlightened individuals’ rules against corruption and violence, we lack the political will to engage in the transformation of the whole world for the good of all earthlings,” said Rev. Mayson.

According to him, consumer culture has become a fine-tuned instrument for keeping people incomplete, shallow and dehumanised.

“Religions are self-centred. Leaders from most of the religious groupings criticised apartheid but they never joined the struggle to assist in demolishing apartheid. It appears as if religious institutions are not able to address the causes of poverty because they themselves are too rich and too powerful,” said Rev. Mayson.

He ended with the following words: “What we need is a leap of faith. Beyers knew that. The world is waiting for people to claim their legacy and to accomplish a post-religious secular spirituality of ubuntu.”

Rev. Mayson is a former Head of Religious Affairs of the ANC. He had also been a former staff member of the Christian Institute before it was banned. Furthermore, he was the Editor of Pro Veritate. Before he retired, he had also been involved in the South African Council of Churches and the World Conference for Peace.

The memorial lecture, a collaborative effort of the UFS and Kagiso Trust, endeavours to involve South Africans in dialogue about issues that affect our nation. This year the lecture was presented at the UFS for the first time and it will take place on the Qwaqwa Campus of the UFS next year.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
16 September 2010
 

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