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31 March 2020 | Story Leonie Bolleurs | Photo Supplied
UFS Covid-19 vaccine research team
Prof Robert Bragg and members of the Veterinary Biotechnology research group believe that finding a vaccine for COVID-19 will not be a ‘quick fix’. From the left are: Prof Bragg, Samantha McCarlie, Liese Kilian, and Dr Charlotte Boucher-van Jaarsveld. The photo was taken during the World Veterinary Poultry Association congress in Thailand in 2019.

On 31 March 2020, there were 804 061 coronavirus cases and 39 064 deaths globally due to the outbreak. According to media reports, there is still no licensed vaccine for COVID-2019 – the cause of our current global health emergency.  

Prof Robert Bragg, researcher at the University of the Free State (UFS), says this is without a doubt the most pressing research need in the world today. 

The Veterinary Biotechnology research group in the Department of Microbial, Biochemical, and Food Biotechnology at the UFS recently submitted an article for publication on the design of a possible COVID-19 vaccine, based on work they have done on infectious bronchitis virus (also a coronavirus). The article, authored by the group of which Prof Bragg is a member, is titled: A sub-unit vaccine produced in 'Yarrowia lipolytica' against COVID-19: Lessons learnt from infectious bronchitis virus. 

The research group, consisting of researchers and postgraduate students, is mostly looking at strategies for improved disease control, mainly in avian species, through vaccine development, treatment, and biosecurity.

Prof Bragg says their main aim with this study was to get the research out there so that the bigger pharmaceutical companies could take up the design of a possible COVID-19 vaccine and assist with the development of a vaccine. 

He says the research group’s role in this lengthy process would be to express the protein, which could be used in the development of a possible vaccine. “Thereafter, it will have to be taken up by a vaccine manufacturer to get the vaccine made and to the market.”

Developing a vaccine
Liese Kilian, a member of the research group, finished writing up her MSc thesis in Microbiology in the UFS Department of Microbial, Biochemical, and Food Biotechnology in December 2019 – the same time that COVID-19 originated in China. She has been working on the development of an edible sub-unit vaccine against the infectious bronchitis virus (IBV), which is a widespread avian coronavirus. This virus is specific to poultry and is different from COVID-19. 

Kilian’s project was conducted under the supervision of Prof Bragg and Dr Charlotte Boucher-van Jaarsveld. Dr Boucher-van Jaarsveld is a research fellow in the university’s Department of Microbial, Biochemical and Food Biotechnology.

Kilian, with the assistance of Samantha Mc Carlie, currently a master’s student in the research group, substituted the genetic code of the IBV with the genetic code of the COVID-19 virus, which were already published at that stage. Thus, a gene for the development of a possible sub-unit vaccine against the S1 spike protein of COVID-19 was developed for expression in the same yeast strain used to express the spike protein of IBV. A sub-unit vaccine can be described as part of a pathogen, triggering an immune response against the pathogen from which it is derived.

After Killian successfully developed the gene for this study, she expressed the S1 spike protein of the IBV in a yeast-based expression system developed by the research group. Dr Boucher-van Jaarsveld says this simply means that the yeast takes up the foreign genetic material (viral gene) into its own genetic make-up and makes more of this protein as if it is part of the yeast’s normal material. 

“The images of COVID-19 are being shown constantly in the media and the ‘spikes’ can be seen on all of these images. These spikes are very typical for all coronaviruses and there is some level of similarity between the structure of these spikes in many of the coronaviruses,” Prof Bragg adds.

According to the World Health Organisation, the spike protein is a promising candidate for a sub-unit vaccine due to its immunogenicity and safety, as well as manufacturing and stability considerations during large-scale development.

Prof Bragg says there are many different expression systems that are widely used. Producing the sub-unit vaccine in a yeast species is beneficial for the work they are doing. A yeast expression system is favourable as large-scale production, is less expensive compared to mammalian cell lines, and can be applied as an edible vaccine.

“The technology to grow massive volumes of yeast are also very well established. This, after all, is how beer is made!” Prof Bragg says. Dr Boucher-van Jaarsveld adds: “The expression of an antigen is not necessarily just geared towards vaccines but can also be used in the development of diagnostic tests to screen populations for infections.”

Working with other researchers
“Now that the situation is all but out of control, we maybe need to investigate the possibilities of working with other key researchers at the UFS as well as other universities in South Africa to develop the vaccine or diagnostic reagents locally. Discussions on this aspect are already underway.”

Several other universities in South Africa are also working to find a cure for the virus. Government availed funding for more research on the matter. According to Higher Education, Science and Technology Minister, Blade Nzimande, the University of Cape Town, the Council for Scientific and Industrial Research, as well as the Vaccines Institute of Southern Africa are working on the development of a vaccine.

Prof Bragg expressed the hope of obtaining funding for this work. “Because without funding, we will not be able to do anything with this data,” he says. They are currently investigating different funding options. 

“The sooner we start on the development of a vaccine, the sooner there will be one, but it will not be a ‘quick fix’. It must be stressed that, even if vaccine development is fast-tracked through the regulatory bodies, it will take many months (if not years) to move from the laboratory to the first human experimentation. It will take even longer before any human vaccine can be rolled out,” says Prof Bragg.



News Archive

21 Icons: 21 Years of Freedom Collection at the University of the Free State
2015-09-02

   

In Prayer and Protest - Sophia Williams De Bruyn

The Johannes Stegmann Art Gallery, in partnership with 21 Icons, is hosting the 21 Years of Freedom Collection, an exhibition specially curated for the University of the Free State.
21 Icons celebrates a heroic past and inspires a hopeful future. The project was launched in 2013 as an initiative that uses film, photography and written narrative to celebrate the lives of extraordinary South Africans. It highlights people who have been catalysts in shaping society, on a local or global level and across a variety of contexts: in a social, political, environmental or artistic sense.

It is the brainchild of internationally renowned photographer and filmmaker Adrian Steirn, whose primary source of inspiration was the life of Nelson Mandela. In one way or another, all of the men and women featured in the project have extended his legacy, making a magnificent impact on South Africa and beyond.

  

Beautiful Sacrifice - Albie Sachs

21 Years of Freedom features 21 icons from the first and second seasons of the project. It includes the last official photographic portrait of Nelson Mandela and many of his friends and fellow struggle heroes. Behind each portrait lies a carefully planned concept that captures the essence of each icon, capturing their spirit and distinct legacy.

Among the other extraordinary South Africans featured in this collection, are struggle icons Ahmed Kathrada and Advocate George Bizos, Archbishop Desmond Tutu, human rights and environmental activist Kumi Naidoo, celebrated storyteller Gcina Mhlophe, Nobel laureate Nadine Gordimer, activist and musician Yvonne Chaka Chaka, gender activist Sophia Williams De Bruyn and artist William Kentridge.

    

The Full Report - Zubeida Jaffer

The 21 Icons was created as a movement for positive change. By sharing the stories of iconic South African men and women, the intention is to inspire new generations to follow in their footsteps.  With the country celebrating 21 years of democracy but still grabbling with injustices, the message that everyone can do something to make a difference, is portrayed in these powerful and inspiring stories.

Writer-in-residence and well-respected journalist, Zubeida Jaffer, who features among the collection of 21 striking photographs, opened the exhibition saying, “I feel like I’m surrounded by a circle of energy from which I have been fortunate to draw strength …It’s a choice that we make…whether to draw energy from those who are positive and forward looking or to surround ourselves with people who are fearful.  There is a lot to be fearful about in our country. We have lived through very fearful and difficult times.  But to cope with these times, those people and many others have kept their focus on hope.  They have kept their focus on what is possible…and what we would like South Africa to be in the future.”

For more information on 21 Icons: 21 Years of Freedom Collection contact the Johannes Stegmann Art Gallery at +27 (0)51 401 2706 or dejesusav@ufs.ac.za

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