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31 March 2020 | Story Leonie Bolleurs | Photo Supplied
UFS Covid-19 vaccine research team
Prof Robert Bragg and members of the Veterinary Biotechnology research group believe that finding a vaccine for COVID-19 will not be a ‘quick fix’. From the left are: Prof Bragg, Samantha McCarlie, Liese Kilian, and Dr Charlotte Boucher-van Jaarsveld. The photo was taken during the World Veterinary Poultry Association congress in Thailand in 2019.

On 31 March 2020, there were 804 061 coronavirus cases and 39 064 deaths globally due to the outbreak. According to media reports, there is still no licensed vaccine for COVID-2019 – the cause of our current global health emergency.  

Prof Robert Bragg, researcher at the University of the Free State (UFS), says this is without a doubt the most pressing research need in the world today. 

The Veterinary Biotechnology research group in the Department of Microbial, Biochemical, and Food Biotechnology at the UFS recently submitted an article for publication on the design of a possible COVID-19 vaccine, based on work they have done on infectious bronchitis virus (also a coronavirus). The article, authored by the group of which Prof Bragg is a member, is titled: A sub-unit vaccine produced in 'Yarrowia lipolytica' against COVID-19: Lessons learnt from infectious bronchitis virus. 

The research group, consisting of researchers and postgraduate students, is mostly looking at strategies for improved disease control, mainly in avian species, through vaccine development, treatment, and biosecurity.

Prof Bragg says their main aim with this study was to get the research out there so that the bigger pharmaceutical companies could take up the design of a possible COVID-19 vaccine and assist with the development of a vaccine. 

He says the research group’s role in this lengthy process would be to express the protein, which could be used in the development of a possible vaccine. “Thereafter, it will have to be taken up by a vaccine manufacturer to get the vaccine made and to the market.”

Developing a vaccine
Liese Kilian, a member of the research group, finished writing up her MSc thesis in Microbiology in the UFS Department of Microbial, Biochemical, and Food Biotechnology in December 2019 – the same time that COVID-19 originated in China. She has been working on the development of an edible sub-unit vaccine against the infectious bronchitis virus (IBV), which is a widespread avian coronavirus. This virus is specific to poultry and is different from COVID-19. 

Kilian’s project was conducted under the supervision of Prof Bragg and Dr Charlotte Boucher-van Jaarsveld. Dr Boucher-van Jaarsveld is a research fellow in the university’s Department of Microbial, Biochemical and Food Biotechnology.

Kilian, with the assistance of Samantha Mc Carlie, currently a master’s student in the research group, substituted the genetic code of the IBV with the genetic code of the COVID-19 virus, which were already published at that stage. Thus, a gene for the development of a possible sub-unit vaccine against the S1 spike protein of COVID-19 was developed for expression in the same yeast strain used to express the spike protein of IBV. A sub-unit vaccine can be described as part of a pathogen, triggering an immune response against the pathogen from which it is derived.

After Killian successfully developed the gene for this study, she expressed the S1 spike protein of the IBV in a yeast-based expression system developed by the research group. Dr Boucher-van Jaarsveld says this simply means that the yeast takes up the foreign genetic material (viral gene) into its own genetic make-up and makes more of this protein as if it is part of the yeast’s normal material. 

“The images of COVID-19 are being shown constantly in the media and the ‘spikes’ can be seen on all of these images. These spikes are very typical for all coronaviruses and there is some level of similarity between the structure of these spikes in many of the coronaviruses,” Prof Bragg adds.

According to the World Health Organisation, the spike protein is a promising candidate for a sub-unit vaccine due to its immunogenicity and safety, as well as manufacturing and stability considerations during large-scale development.

Prof Bragg says there are many different expression systems that are widely used. Producing the sub-unit vaccine in a yeast species is beneficial for the work they are doing. A yeast expression system is favourable as large-scale production, is less expensive compared to mammalian cell lines, and can be applied as an edible vaccine.

“The technology to grow massive volumes of yeast are also very well established. This, after all, is how beer is made!” Prof Bragg says. Dr Boucher-van Jaarsveld adds: “The expression of an antigen is not necessarily just geared towards vaccines but can also be used in the development of diagnostic tests to screen populations for infections.”

Working with other researchers
“Now that the situation is all but out of control, we maybe need to investigate the possibilities of working with other key researchers at the UFS as well as other universities in South Africa to develop the vaccine or diagnostic reagents locally. Discussions on this aspect are already underway.”

Several other universities in South Africa are also working to find a cure for the virus. Government availed funding for more research on the matter. According to Higher Education, Science and Technology Minister, Blade Nzimande, the University of Cape Town, the Council for Scientific and Industrial Research, as well as the Vaccines Institute of Southern Africa are working on the development of a vaccine.

Prof Bragg expressed the hope of obtaining funding for this work. “Because without funding, we will not be able to do anything with this data,” he says. They are currently investigating different funding options. 

“The sooner we start on the development of a vaccine, the sooner there will be one, but it will not be a ‘quick fix’. It must be stressed that, even if vaccine development is fast-tracked through the regulatory bodies, it will take many months (if not years) to move from the laboratory to the first human experimentation. It will take even longer before any human vaccine can be rolled out,” says Prof Bragg.



News Archive

UFS congratulates Wayde van Niekerk and other students for their national and international accomplishments
2015-09-17



Kovsies showing the world that success is inevitable
Photo: Johan Roux

Students from the University of the Free State (UFS) have not only conquered South Africa (SA), they have also left footprints in the world. During 2014 and 2015, our students have performed well in various fields.

A special celebratory event was held at the Bloemfontein Campus on Tuesday 15 September 2015. Members of the Rectorate, Student Representative Council (SRC), Grey College Secondary School personnel and former principal, Mr Johan Volsteedt, as well as UFS staff members and students gathered at the Callie Human Centre to congratulate those students who have recently represented the university with excellence atnational and global levels. Also present were representatives from the Department of Sports Arts Culture and Recreation (SACR) in the Free State and the Free State Sport Confederation (FSSC).

Sports leadership has proven to be one of Kovsies’ areas of expertise. From Wayde van Niekerk making international headlines as the 2015 Men’s 400m World Sprint Champion, to Nicole Walraven who was named as the SA under-21 Hockey 2015 Player of the Year, speaks the language of winners.

Wayde believes that his achievements are also for his family, friends, mentors, and the university community to rejoice in.“What I achieved is our achievement,” he said “the person I am today is because of the people around me.” Also supporting him at this event was MsAns Botha, his coach together with his family and friends.

Andricia Hinckemann’s commitment to promote environmental sustainability in light of the global warming crisis earned her the Miss Earth SA 2015 second princess status.

The UFS Debating Society also joined the ranks as highfliers when announced as South African National Universities Debating Champions for 2015. The UFS team competed in nine preliminary rounds. Devon Watson and NkahisengRalepeli from the UFS had to fight their way through nine preliminary rounds to the finals. Competing in the category English as a First Language, Devon and Nkahiseng brought yet another championship title home.

Success is music to our ears here at Kovsies, Veritas and Marjolein showed us that music can also symbolize success. These residence serenade groups took first and second place, respectively, at the 2015 ATKV National University Sêr competition.

Other students who have the world in their hands and are striving to make it a better place include Rolene Strauss (Miss World 2015), Elzane van der Berg (Deaf Miss South Africa 2014), the Shimlas (2015 Varsity Cup champions),KovsieNetball (2014 Varsity Netball champions and winners of 2014 National Premier League), KovsieTennis (2014 USSA Champions) and Varsity Sevens Champions 2015.

Prof Jonathan Jansen, Vice-Chancellor and Rector of the university remarked upon the inevitable nature of success amongst our university’s students. “Whether they are in athletics, netball, or debating, Kovsie students do well in every aspect of their lives.”

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