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31 March 2020 | Story Leonie Bolleurs | Photo Supplied
UFS Covid-19 vaccine research team
Prof Robert Bragg and members of the Veterinary Biotechnology research group believe that finding a vaccine for COVID-19 will not be a ‘quick fix’. From the left are: Prof Bragg, Samantha McCarlie, Liese Kilian, and Dr Charlotte Boucher-van Jaarsveld. The photo was taken during the World Veterinary Poultry Association congress in Thailand in 2019.

On 31 March 2020, there were 804 061 coronavirus cases and 39 064 deaths globally due to the outbreak. According to media reports, there is still no licensed vaccine for COVID-2019 – the cause of our current global health emergency.  

Prof Robert Bragg, researcher at the University of the Free State (UFS), says this is without a doubt the most pressing research need in the world today. 

The Veterinary Biotechnology research group in the Department of Microbial, Biochemical, and Food Biotechnology at the UFS recently submitted an article for publication on the design of a possible COVID-19 vaccine, based on work they have done on infectious bronchitis virus (also a coronavirus). The article, authored by the group of which Prof Bragg is a member, is titled: A sub-unit vaccine produced in 'Yarrowia lipolytica' against COVID-19: Lessons learnt from infectious bronchitis virus. 

The research group, consisting of researchers and postgraduate students, is mostly looking at strategies for improved disease control, mainly in avian species, through vaccine development, treatment, and biosecurity.

Prof Bragg says their main aim with this study was to get the research out there so that the bigger pharmaceutical companies could take up the design of a possible COVID-19 vaccine and assist with the development of a vaccine. 

He says the research group’s role in this lengthy process would be to express the protein, which could be used in the development of a possible vaccine. “Thereafter, it will have to be taken up by a vaccine manufacturer to get the vaccine made and to the market.”

Developing a vaccine
Liese Kilian, a member of the research group, finished writing up her MSc thesis in Microbiology in the UFS Department of Microbial, Biochemical, and Food Biotechnology in December 2019 – the same time that COVID-19 originated in China. She has been working on the development of an edible sub-unit vaccine against the infectious bronchitis virus (IBV), which is a widespread avian coronavirus. This virus is specific to poultry and is different from COVID-19. 

Kilian’s project was conducted under the supervision of Prof Bragg and Dr Charlotte Boucher-van Jaarsveld. Dr Boucher-van Jaarsveld is a research fellow in the university’s Department of Microbial, Biochemical and Food Biotechnology.

Kilian, with the assistance of Samantha Mc Carlie, currently a master’s student in the research group, substituted the genetic code of the IBV with the genetic code of the COVID-19 virus, which were already published at that stage. Thus, a gene for the development of a possible sub-unit vaccine against the S1 spike protein of COVID-19 was developed for expression in the same yeast strain used to express the spike protein of IBV. A sub-unit vaccine can be described as part of a pathogen, triggering an immune response against the pathogen from which it is derived.

After Killian successfully developed the gene for this study, she expressed the S1 spike protein of the IBV in a yeast-based expression system developed by the research group. Dr Boucher-van Jaarsveld says this simply means that the yeast takes up the foreign genetic material (viral gene) into its own genetic make-up and makes more of this protein as if it is part of the yeast’s normal material. 

“The images of COVID-19 are being shown constantly in the media and the ‘spikes’ can be seen on all of these images. These spikes are very typical for all coronaviruses and there is some level of similarity between the structure of these spikes in many of the coronaviruses,” Prof Bragg adds.

According to the World Health Organisation, the spike protein is a promising candidate for a sub-unit vaccine due to its immunogenicity and safety, as well as manufacturing and stability considerations during large-scale development.

Prof Bragg says there are many different expression systems that are widely used. Producing the sub-unit vaccine in a yeast species is beneficial for the work they are doing. A yeast expression system is favourable as large-scale production, is less expensive compared to mammalian cell lines, and can be applied as an edible vaccine.

“The technology to grow massive volumes of yeast are also very well established. This, after all, is how beer is made!” Prof Bragg says. Dr Boucher-van Jaarsveld adds: “The expression of an antigen is not necessarily just geared towards vaccines but can also be used in the development of diagnostic tests to screen populations for infections.”

Working with other researchers
“Now that the situation is all but out of control, we maybe need to investigate the possibilities of working with other key researchers at the UFS as well as other universities in South Africa to develop the vaccine or diagnostic reagents locally. Discussions on this aspect are already underway.”

Several other universities in South Africa are also working to find a cure for the virus. Government availed funding for more research on the matter. According to Higher Education, Science and Technology Minister, Blade Nzimande, the University of Cape Town, the Council for Scientific and Industrial Research, as well as the Vaccines Institute of Southern Africa are working on the development of a vaccine.

Prof Bragg expressed the hope of obtaining funding for this work. “Because without funding, we will not be able to do anything with this data,” he says. They are currently investigating different funding options. 

“The sooner we start on the development of a vaccine, the sooner there will be one, but it will not be a ‘quick fix’. It must be stressed that, even if vaccine development is fast-tracked through the regulatory bodies, it will take many months (if not years) to move from the laboratory to the first human experimentation. It will take even longer before any human vaccine can be rolled out,” says Prof Bragg.



News Archive

Five mega projects to help reposition the UFS
2008-02-01

The University of the Free State (UFS) today announced that it will focus on five mega-projects to help reposition the UFS in the next five years as one of South Africa’s leading universities that is successfully managing excellence and diversity.

Speaking at the official opening of the university today, the Rector and Vice-Chancellor, Prof. Frederick Fourie, identified the five mega projects as:

  • The successful implementation of strategic academic clusters to focus the teaching and research expertise of the UFS.
  • The development and implementation of new models of teaching and learning.
  • Finding new sources of income (including third-stream income) to minimise dependence on government subsidies and tuition fees.
  • Creating a new institutional culture for the university by finalising the Institutional Charter.
  • The ongoing transformation of the UFS in all its dimensions.

According to Prof. Fourie, the strategic clusters – initiated in 2006 – are a very important initiative which is aimed at making the UFS a world leader in six broad areas. The focus of the six clusters has now been determined. These clusters are not just research based, but will include postgraduate programmes and filter down to undergraduate learning programmes and curricula.

He also indicated that other research at the UFS will continue to be supported and funded as before.

The second project, to establish a new teaching and learning model, is meant to address current success rates which indicate the need for this issue to receive a high priority.

New income streams to enable higher levels of financial sustainability is the third project, especially in view of dwindling government subsidies and limits on student numbers. This is necessary to fund sustained higher levels of investment in the quality of academic activities and in the necessary capacity and facilities.

Prof. Fourie said the fourth project regarding institutional culture is an ongoing effort to create a sense of belonging for all staff and students at the UFS through the adoption of an Institutional Charter for the university.

“What the draft Charter does – in addition to describing overarching values espoused by the institution and its people – is to describe the outlines and constitutive principles of the ‘post-redress’ UFS,” said Prof. Fourie.

The Charter – initially launched in 2007 – is and remains a critical element of guiding transformation effectively and speedily towards a widely-accepted goal. It is a critical element of the “social sustainability and robustness” of a new UFS, especially in tumultuous political times.

The fifth project is the Transformation Plan, launched in 2007. “We simply must pursue this plan diligently, given our commitment to comprehensive and deep transformation, and to best practice transformation. All universities will have to face up to the challenge of transformation and the UFS can break new ground, as it did in the past by managing transformation innovatively and creating a campus where all can find their rightful place,” said Prof. Fourie.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
1 February 2008
 

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