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07 May 2019 | Story Valentino Ndaba | Photo Charl Devenish
Noko Masalesa
Noko Masalesa, Director of Protection Services, in conversation with students and stakeholders to plan a safe way forward.

Safety and security are human rights that constitute social justice. At the centre of the agenda at the University of the Free State’s (UFS) Social Justice Week held on the Bloemfontein Campus from 17-22 April 2019 were discussions about off-campus safety. Stakeholders agreed on an upgrade to security measures in order to ensure the success and wellbeing of the student population.

A call to students

Prof John Mubangizi, Dean of the Faculty of Law, in his capacity as representative of the UFS Rector and Vice-Chancellor, Prof Francis Petersen, expressed his view on institutions of higher learning no longer functioning as ivory towers. “For any initiative to succeed, collaboration is necessary between key roleplayers,” he said.

He aptly pointed out that: “We cannot underscore the importance of safety and security, not only for the university but also for the communities around us. What the university does benefits the community and vice versa. I pledge the university’s commitment to play a leading part to ensure that the collaboration works,” said Prof Mubangizi.

Beefing up security: Who is involved?

In view of the collaborative effort Prof Mubangizi alluded to, the engagement was twofold. First was the roundtable discussion facilitated by Protection Services which then escalated into a public dialogue where students had the opportunity to interact with external delegates.

The South African Police Services, Community Police Forum, Private Security, Mangaung Metropolitan Municipality, Provincial Commissioner, and Deputy Minister of Police were well represented in this critical conversation. Internally, members of Protection Services, Housing and Residence Affairs, Student Affairs, Institute for Social Justice and Reconciliation, Student Representative Council, and the Department of Criminology heard the plight of off-campus safety faced by students.

Changes in the horizon

The discussions culminated with recommendations which will see the future of student safety take a different direction. According to Skhululekile Luwaca, former SRC president, these include “the municipality’s commitment to immediately address issues such as street lights and enforcing by-laws, ensuring an integrated accreditation system, and drafting a policy for off-campus accommodation, running more crime awareness campaigns, and giving police patrols more visibility.”

In addition to resolving to set up a student safety forum with all the stakeholders, the Mangaung Metropolitan Municipality has invited the UFS to join Reclaim the City – a safety forum where practical solutions to crime are devised and implemented on a weekly basis.


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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