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Fighting COVID-19: Here is how we are helping

16 April 2020 | Story Department of Communication and Marketing | Photo Charl Devenish

Farmovs — In 2019, FARMOVS was pre-qualified by the WHO to support clinical studies aimed at improving access to quality generic medicines across the globe.

The University of the Free State (UFS) is committed to supporting government’s efforts to overcome the COVID-19 pandemic. During this challenging time, dedicated staff members at the UFS continue to provide services as a testimony to their commitment to advance public knowledge of COVID-19 for the greater good of South Africa.

The following is a synopsis of the areas in which the UFS is actively assisting.

Public Health Emergency Solidarity Trial
Clinicians from the Department of Internal Medicine, the Department of Critical Care, and the Division of Virology will be working with FARMOVS to participate in the Public Health Emergency Solidarity Trial initiated by the World Health Organization (WHO). This international randomised trial will evaluate four treatment options (remdesivir, lopinavir/ritonavir, lopinavir/ritonavir plus interferon, chloroquine or hydroxychloroquine) for the treatment of COVID-19.

The trial is expected to include more than 45 countries worldwide, including a number of South African sites.

Farmovs
FARMOVS is in a planning process to support all the Bloemfontein hospitals, including Pelonomi, Universitas, 3 Military Hospital, Mediclinic, and Rosepark, in conducting the largest global trial on COVID-19 – the Public Health Emergency Solidarity Trial, under leadership of the WHO.

Negotiations are ongoing between the UFS and the Department of Health in the Free State for FARMOVS to offer support with the continuation of healthcare to non-COVID-19 patients in an attempt to free up space at Universitas Hospital for isolation of COVID-19 patients.

In 2019, FARMOVS was pre-qualified by the WHO to support clinical studies aimed at improving access to quality generic medicines across the globe. FARMOVS also receives feasibility requests for support with the evaluation of existing drugs (repurposing) as well as the development of novel drugs for the treatment of COVID-19 – this is an ongoing process.

Disaster Management Training and Education Centre (DiMTEC)
DiMTEC represents the UFS on the Provincial Joint Operation Centre (PROVJOC). The PROVJOC is a fully equipped, dedicated facility that is proactively established to enable all relevant role players /disciplines to jointly manage all safety and security-related aspects of any planned event or any major incident which has occurred or is imminent – especially in the response and recovery operations phase – at the strategic and/or tactical level, using the Unified Command System. This facility is also linked to all other established safety and security centres.

Research and Innovation
The UFS hosts a SARChI Research Chair in vector-borne and zoonotic diseases, and recently invested in the establishment of a biosafety level-3 facility. Hence, there is expertise on the campus to plan and conduct research on zoonotic and medically significant viruses. In addition, there are research groups focusing on protein expression systems with potential for utilisation in the development of diagnostic assays with application in either diagnosis or surveillance.

Currently, researchers at the UFS have established several projects that will contribute directly towards the COVID-19 outbreak.

News Archive

#Women'sMonth: Lack of HIV education still affects children

2017-08-17

Dr Nickie Goedhals, Senior Lecturer and Pathologist
in Medical Microbiology and Virology at the UFS.
Photo: Sonia Small

“Despite all the advances in the management and prevention of HIV, children still become infected every day, often due to lack of education and access to health care.” This is according to Dr Nickie Goedhals, Senior Lecturer and Pathologist in Medical Microbiology and Virology at the University of the Free State (UFS).

Study published in UK medical Journal
A case study she was part of and published in the UK medical journal The Lancet in 2012, demonstrates the transmission of HIV to a child through surrogate breastfeeding. This study is one of the many highlights in the young researcher’s career. She received her first rating from the National Research Foundation (NRF) in 2017 for the work she has done in Medical Virology over the past eight years.

According to the above-mentioned study, only about 1% of infants in South Africa are being breastfed by a surrogate. However, results from a study in the Free State showed that shared breastfeeding by a non-biological caregiver was the most important factor associated with HIV infection in discordant mother-child pairs. Therefore, continued education about the risk of HIV transmission is needed.

Dr Goedhals is also continuing with research on HIV by looking at HIV drug resistance. She is in the process of starting new projects focusing on HIV infection and drug resistance in infants.

PSP helped with NRF-rating
She says, although her NRF Y2-rating is the starting point of a research career, it shows that she is heading in the right direction, and it “gives access to research funds through the NRF for future projects.” Other important research she conducted was on Crimean-Congo haemorrhagic fever – the study for her PhD.

The Prestige Scholars Programme (PSP) at the UFS is the reason that she applied for the rating. “With all the service delivery, teaching, and administrative responsibilities of academic medicine, it is easy to lose focus. The PSP has really helped to create a focused and stimulating environment for research.” According to her, the PSP also provides access to a network of peers and senior staff at the UFS, as well as exposure to national and international experts.

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