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16 April 2020 | Story Department of Communication and Marketing | Photo Charl Devenish
Farmovs
In 2019, FARMOVS was pre-qualified by the WHO to support clinical studies aimed at improving access to quality generic medicines across the globe.

The University of the Free State (UFS) is committed to supporting government’s efforts to overcome the COVID-19 pandemic. During this challenging time, dedicated staff members at the UFS continue to provide services as a testimony to their commitment to advance public knowledge of COVID-19 for the greater good of South Africa.

The following is a synopsis of the areas in which the UFS is actively assisting.

Public Health Emergency Solidarity Trial
Clinicians from the Department of Internal Medicine, the Department of Critical Care, and the Division of Virology will be working with FARMOVS to participate in the Public Health Emergency Solidarity Trial initiated by the World Health Organization (WHO). This international randomised trial will evaluate four treatment options (remdesivir, lopinavir/ritonavir, lopinavir/ritonavir plus interferon, chloroquine or hydroxychloroquine) for the treatment of COVID-19. 

The trial is expected to include more than 45 countries worldwide, including a number of South African sites. 

Farmovs

FARMOVS is in a planning process to support all the Bloemfontein hospitals, including Pelonomi, Universitas, 3 Military Hospital, Mediclinic, and Rosepark, in conducting the largest global trial on COVID-19 – the Public Health Emergency Solidarity Trial, under leadership of the WHO.   

Negotiations are ongoing between the UFS and the Department of Health in the Free State for FARMOVS to offer support with the continuation of healthcare to non-COVID-19 patients in an attempt to free up space at Universitas Hospital for isolation of COVID-19 patients. 

In 2019, FARMOVS was pre-qualified by the WHO to support clinical studies aimed at improving access to quality generic medicines across the globe.  FARMOVS also receives feasibility requests for support with the evaluation of existing drugs (repurposing) as well as the development of novel drugs for the treatment of COVID-19 – this is an ongoing process.

Disaster Management Training and Education Centre (DiMTEC)
DiMTEC represents the UFS on the Provincial Joint Operation Centre (PROVJOC). The PROVJOC is a fully equipped, dedicated facility that is proactively established to enable all relevant role players /disciplines to jointly manage all safety and security-related aspects of any planned event or any major incident which has occurred or is imminent – especially in the response and recovery operations phase – at the strategic and/or tactical level, using the Unified Command System. This facility is also linked to all other established safety and security centres.

Research and Innovation
The UFS hosts a SARChI Research Chair in vector-borne and zoonotic diseases, and recently invested in the establishment of a biosafety level-3 facility. Hence, there is expertise on the campus to plan and conduct research on zoonotic and medically significant viruses. In addition, there are research groups focusing on protein expression systems with potential for utilisation in the development of diagnostic assays with application in either diagnosis or surveillance.

Currently, researchers at the UFS have established several projects that will contribute directly towards the COVID-19 outbreak.


News Archive

Afromontane Research Unit makes climate change inroads
2017-10-28



Description: Prof Mukwada Tags: Prof Mukwada

Prof Geofrey Mukwada

The Afromontane Research Unit (ARU) has recently made inroads in climate-change research. This has been achieved through work published by Professor Geofrey Mukwada and Professor Desmond Manatsa, whose research could make it possible to predict El Nino Southern Oscillation (ENSO) several months before its occurrence. 

Professor Manatsa is an ARU postdoctoral fellow currently collaborating with Professor Mukwada on an ongoing climate-change research project. The two experts noted that ENSO is one of the most important climate phenomena on earth, due to its ability to change the global atmospheric circulation, which in turn, influences temperature and precipitation across the world.

Climate change scientific breakthrough

“This is a tremendous breakthrough, because humanity as a whole has been looking for answers regarding the origins of climate-related hazards which are worsening, yet becoming more frequent and difficult to predict. In some cases, floods and droughts occur in the same season, and within the same geographical area. These extreme climate events are becoming more frequent, often leading to loss of life and threatening national economies and livelihoods,” said Professor Mukwada, coordinator of the ARU sub-theme on Living and Doing Business In Afromontane Environments.

During an interview with the Southern Times, Professor Manatsa revealed that the El Nino Southern Oscillation (ENSO) is initiated and sustained in the tropical Pacific, a fact that has eluded climate scientists for years. “It was an unresolved puzzle which limited the successful prediction of ENSO events with reasonable lead time. Climate scientists were only able to know with some degree of certainty that the event would occur once it had started, just a few months before its impacts were felt,” Professor Manatsa said.

Prof Manatsa is upbeat that a lot of headway has now been made towards unravelling the mystery of ENSO’s origin. “The necessity of the inclusion of the solar energy changes due to ozone alterations in the upper atmosphere should significantly impact on the realistic version of ENSO in climate models. This in turn should not only provide more accurate ENSO forecasts for the region, but a longer lead time for users to prepare for the event,” he said.

ENSO is a climate phenomenon based in the tropical Pacific Ocean. Its events bring good rains and even floods over most parts of the world in some years and droughts in others, depending on whether the phenomenon is in a warm or cold phase. The warm phase is referred to as El Nino, when the waters over the tropical east Pacific are heated up, but when cooled, it is termed La Nina. La Nina was responsible for the favourable rains over much of Southern Africa, including Zimbabwe, during the 2016/17 rainfall season. The El Nino occurrence a year before had devastating drought effects that was characterised by scorching heat and widespread water shortages. This work was published in a high-profile journal, Nature Scientific Reports

ARU is a flagship inter- and trans-disciplinary research programme focusing on the under-researched area of montane communities. It was launched in June 2015 and is based on the Qwaqwa Campus. 

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