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06 August 2020 | Story Leonie Bolleurs | Photo Supplied
Carien Denner will tell her 15-year-old self to drink more water, use more sunscreen, and to be present in the moment to not miss out on a single opportunity.

The Ruforum Wool project strives to ensure sustainable growth for communal wool farmers in the Free State by enabling them to compete in wool quality with commercial wool farmers through end-to-end development of the wool value chain. In this project, small-scale wool farmers and community members are identified and invited to take part in the project where they learn various skills in each component of the wool value chain. As a result, production by the communal wool growers is transformed from an underachieving enterprise to a profitable, sustainable, and renewable venture that will enhance the livelihoods of wool producers in the community.  

An interview with Carien Denner, Project Manager in the Department of Consumer Science at the University of the Free State (UFS), revealed that there is more to this woman who is working hard to enhance the livelihoods of communities. 

Please tell us about yourself: Who are you, and what do you do? 

“I am involved in the Community Gardens Food Security project, as well as the Ruforum Wool project. With the latter project, I serve on the management team that was established to commercialise wool production in the communal areas of the province by developing strategies to overcome the various challenges faced by these growers.”

Is there a woman who inspires you and who you would like to celebrate this Women’s Month? Why?

“My mother, a teacher for more than 43 years, epitomises my idea of a dynamic woman being kind, encouraging, truthful, fun, strong, selfless, and brave through everything that life has thrown at her. I believe that a mother’s love and sacrifices are what makes us as women dynamic – each in her own right.”

What are some of the challenges you have faced in your life that have made you a better woman?

“When my dad passed away (I was 12 years old), I saw my mom being an ironwoman who never gave up and never got tired. Instead, she showed us what courage looks like and set an amazing example of strength and perseverance for my brother and me.”

What advice would you give to the 15-year-old you?

“This is not a good question to ask someone in the middle of a pandemic! I would tell myself to appreciate every day for what it is and not to stress about the future too much.  

What would you say makes you a champion woman [of the UFS]?

“I think a champion woman is someone who – especially during these trying times – supports, empowers, and uplifts her fellow man. The Ruforum Wool project and everyone who is involved in it is doing precisely that. We need to empower, uplift, and encourage our emerging farmers to restore dignity and ensure sustainability in agriculture, food production, and their general participation in the economy. Communities surrounding them are equally in need of sustainable employment opportunities where valuable skills can be learned in order to provide for themselves and their families. This is what we strive to do to make a meaningful difference through our efforts.”

 

WATCH: Carien Denner from the UFS Department of Consumer Sciences serves on the management team of the Community Gardens Food Security project as well as the Ruforum Wool project, where she strives to enhance the livelihoods of communities. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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