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21 December 2020 | Story Andre Damons | Photo Supplied
The research team helps a giraffe to get up after they have finished collecting data.

Researchers from the University of the Free State (UFS) hope their research to investigate why some animals prefer or avoid some habitats, will also create awareness for the plight of giraffes which have lost more than 80% of some of their subspecies in East Africa and are facing extinction in the wild.

Dr Marietjie Schutte-Smith, Senior Lecturer in the Department of Chemistry, says the collaborative research being done in South Africa is very unique and could help save subspecies from the brink of extinction – as South Africa has managed to double its giraffe numbers whilst subspecies have declined tremendously.

Why some animals prefer or avoid some habitats

“By using modern analysis techniques and instruments (such as drones and GPS devices), it is possible to study complex environments on a spatial ecology scale and has created the opportunity to investigate why some animals prefer or avoid some habitats,” explains wildlife expert Dr Francois Deacon.

“This in turn opened the door to explore geographic, soil and nutritional qualities the giraffe might prefer or avoid. This is one of the main reasons we are exploring the different factors and driving forces behind a large herbivore’s habitat selection, well-being, body condition parameters and physiological adaptations,” Dr Deacon says.

Veld conditions, plant species composition, tree densities and other available resources such as production yield and water quality determine reproduction successes and how animals disperse, move and distribute over an area. Spatial and ecological distributions of giraffe specifically depend on habitat resources and qualities that in turn affect their complex behavioral tactics and survival.

Strange habits

The research was started back in 2010 by Dr Deacon and Prof Nico Smit from the Department of Animal, Wildlife and Grassland Sciences at the UFS with the pioneering of GPS devices to investigate giraffe spatial ecology and habitat use. The current study was initiated as to why the giraffe would utilise one area more than the other, even if the two habitats had the same tree species, says Dr Schutte-Smith.

Dr Deacon contacted Prof Hendrik Visser and Dr Schutte-Smith from the Department of Chemistry for a possible collaborative effort. Ms Jeaneme Kuhn started her MSc research degree on this project in January 2019 and completed her degree in August 2020 with distinction.

Dr Schutte-Smith says from research done at Rooipoort Nature Reserve it was found that a certain group of giraffes had the strange habit of only eating from specific trees, avoiding similar trees a few metres away. “We wanted to see if this behaviour was due to chemical influences, i.e. if there are specific minerals that are possibly in excess at some places which they avoid, especially since there are mines close by.”

Aim of the research

The main aim of this MSc Chemistry degree, according to Dr Schutte-Smith, is to validate an analytical method for testing leaves and soil samples, using IPC, to see if heavy metals (in excess) are present in the soil, leaves and water and whether this has an influence on the browsing pattern of the giraffes. “Then as secondary aims (for the collaborative effort) we would like to investigate if the giraffe can select one area above the other (core home ranges), to understand what the qualities are that they would select for in the preferred area and what the qualities they avoid are in the other. And lastly to understand what the minimum requirements are to keep the animals happy and healthy, but also to investigate how they search for these qualities,” says Dr Schutte-Smith.

Giraffe conservation

Besides creating awareness of the plight of giraffes, the researchers also aim to create a model for conservation via research and education to be used as an example for other countries. This model incorporates students, academia, professionals, sponsors and stakeholders that cover various topics relating to giraffe education, management and conservation.

They would also like to see the UFS as the institution that has contributed the most to giraffe conservation strategies in Africa by being the leading university in the collection and analysis of information about giraffes and their habitats, increasing conservation education awareness about giraffes and African biodiversity and to develop national and/or regional plans aimed at giraffe conservation.

The research team successfully applied for funding which they used for chemicals and solvents to perform testing as well as sampling.

News Archive

Cardiology Unit involved in evaluation of drug for rare genetic disease
2013-01-04

Front from the left, are: Marinda Karsten (study coordinator and registered nurse),
Laumarie de Wet (clinical technologist), Charmaine Krahenbuhl (study coordinator and radiographer),
Lorinda de Meyer (administrator), Andonia Page (study coordinator and enrolled nurse);
back Dr Gideon Visagie (sub investigator), Dr Derick Aucamp (sub investigagtor),
Prof. Hennie Theron, (principal investigator) and Dr Wilhelm Herbst (sub investigator).
Photo: Supplied
09 January 2013


The Cardiology Research Unit at the University of the Free State (UFS) contributed largely to the evaluation of the drug Juxtapid (lomitapide), which was developed by the Aegerion pharmaceutical company and approved by the FDA (Federal Drug Administration). Together with countries such as die USA, Canada and Italy, the UFS’ Unit recruited and evaluated the most patients (5 of 29) for the study since 2008.  

The drug was evaluated in persons with so-called familial homozygous hypercholesterolemia (HoFH).  

Following its approval by the FDA, Juxtapid is now a new treatment option for patients suffering from HoFH. The drug operates in a unique way which brings about dramatic improvements in cholesterol counts.  

According to Prof. Hennie Theron, Associate Professor in the Department of Cardiology at the UFS and Head of the Cardiology Contract Research Unit, HoFH is a serious, rare genetic disease which affects the function of the receptor responsible for the removal of low-density lipoprotein cholesterol (LDL-C) (“bad” cholesterol) from the body. Damage to the LDL receptor function leads to extremely high levels of blood cholesterol. HoFH patients often develop premature and progressive atherosclerosis, which is a narrowing or blockage of the arteries.  

“HoFH is a genetically transmitted disease and the most severe form of hypercholesterolemia. Patients often need a coronary artery bypass or/and aortic valve replacement before the age of 20. Mortality is extremely high and death often occurs before the third decade of life. Existing conventional cholesterol-lowering medication is unsuccessful in achieving normal target cholesterol values in this group of patients.  

“The only modality for treatment is plasmapheresis (similar to dialysis in patients with renal failure). Even with this type of therapy the results are relatively unsatisfactory because it is very expensive and the plasmapheresis has to be performed on a regular basis.  

“The drug Juxtapid, as currently evaluated, has led to a dramatic reduction in cholesterol values and normal values were achieved in several people. No existing drug is nearly as effective.  

“The drug represents a breakthrough in the treatment of familial homozygous hypercholesterolemia. The fact that it has been approved by the FDA, gives further impetus to the findings,” says Prof. Theron.  

In future further evaluation will be performed in other forms of hypocholesterolemia.  

According to Prof. Theron, the findings of the study, as well as the recent successful FDA evaluation, once again confirms the fact that the UFS’ Cardiology Contract Research Unit is doing outstanding work.  

Since its inception in 1992, the Unit has already been involved in more than 60 multi-centre, international phase 2 and 3 drug studies. Several of these studies, including the abovementioned study, really affected the way in which cardiology functions.  

The UFS’ Cardiology Contract Research Unit is being recognised nationally and internationally for its high quality of work and is constantly approached for their involvement in new studies.  

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