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Researchers from the University of the Free State (UFS) and the Central University of Technology (CUT) have recently learned that their research projects will be funded, with one research project even getting double the amount of funding requested. 

The research project of Dr Doors Fonternel, an MMed student working under Dr Edwin Turton in the Department of Anaesthesiology at the UFS, and Prof Ihar Yadroitsau (Igor Yadroitsev), Research Chair in Medical Product Development through Additive Manufacturing and the Faculty of Engineering, Built Environment and Information Technology at CUT, titled 3D Printed laryngoscope for endotracheal intubation, received R400 000 in funding. The project only requested half the amount, but in granting the funding, the evaluation committee was of the opinion that due to the relevance of the research and the long-term sustainability of the project, funding should be adjusted to R400 000.  

Another research project receiving R400 000 in funding, is a project by Dr Alice Brink, Senior Lecturer in the Department of Chemistry at the UFS, and Dr Tshepiso J Makhafola, Assistant Dean: Research, Innovation and Engagement and Senior Lecturer: Clinical Technology in the Faculty of Health and Environmental Sciences at CUT. The committee supported the novelty of the project and the contribution towards both applicants’ participation in the Future Professors’ Programme.
These projects are part of nine collaboration projects between researchers from the UFS and CUT that were approved for funding between 2019 and 2020. The funding ranges from R50 000 to R400 000. 

Using 3D printer technology 

Dr Fonternel says getting more funding than expected gives them the motivation to push through the obstacles presented by a project like this. 

“It is innovative and uncharted, so it helps to know that others also believe in the possibilities. Apart from the design, testing, and validation that this project aims to achieve, we are looking to broaden the scope into materials and sterilisation. We are also looking at acquiring equipment to enable the UFS to be able to design and manufacture devices of similar need and purpose,” says Dr Fonternel.

According to Dr Fonternel, who designed, developed, and then prototyped the video laryngoscope with the help of the Product Development and Testing Station (PDTS) at CUT, he hopes that with this new research, the validated technology of video laryngoscopy could be provided to a much larger medical community.

Prof Yadroitsau’s role is the overall project management, mechanical testing, project analysis, and possible additional fundraising.

“This can be beneficial to rural hospitals and centres with limited funds and equipment and can make a difference in the quality of care we provide to our patients. It has the potential to improve the safety of patients and healthcare workers in our current COVID-19 battle by bringing First World technology to the front line.” 

Valuable contribution to cancer research

Drs Brink and Makhafola will be collaborating on the development and testing of organometallic complexes, primarily model pharmaceuticals that can carry a radioactive metal centre. Their collaboration will develop model lead compounds and then test their biological activity, particularly for anticancer and antimicrobial activities, including toxicological profiling to determine if it is a viable option for future cancer treatment. 

“Drug development has significant challenges, particularly for academic institutions that do not have access to the focused and integrated specialty networks as developed by Big Pharma such as Roche, Novartis, Bayer, etc.  The research and development pathway of a new pharmaceutical agent that becomes commercially available, takes on average 12 years and costs approximately £1,15 bn.”

“For every single drug that receives approval, an estimated 10 000 compounds have been considered as viable options but have failed for one reason or another. Our research collaboration focuses on addressing these two main challenges that hinder academia from successfully entering the drug market.  We hope to identify potential lead compounds with novel mechanisms of action for the development of cancer therapeutics,” says Dr Brink.

This collaborative team hopes to promote and make a valuable contribution to cancer research, specifically towards the discovery of new effective cancer treatments/drugs. 

New ways of imaging patients with rheumatoid arthritis

Dr Evbuomwan Osayande, a nuclear medicine specialist at the UFS/Universitas Academic Hospital, says his research will compare the efficacy of EC-DG (ethylenedicysteine-deoxyglucose) imaging with ultrasound imaging in patients with rheumatoid arthritis. At this stage, the research is still in the protocol phase. A protocol has been submitted to the Health Sciences Research Ethics Committee of the UFS for approval. The project received R350 000. 

“If this imaging modality proves to be highly accurate and can detect disease activity, including low disease activity, much earlier than other investigational tools, it might become a routine imaging modality in the management of patients with rheumatoid arthritis,” says Dr Osayande, the principal investigator in this research.

If we can detect low disease activity with the EC-DG imaging, says Dr Osayande, it will ensure that the rheumatologists will continue patient treatment and thus prevent them from having complications, such as bone erosions and joint destruction. “It is an exciting project and we are all looking forward to the outcome.”

Embracing 4IR

The research project of Dr Thuthukile Jita, Senior Lecturer in the UFS School of Education Studies, and Dr Carlie Luzaan Schlebusch from CUT, investigates the possibilities and affordances of training student teachers to embrace the Fourth Industrial Revolution, specifically by learning to teach Science in schools using mobile devices and mobile apps. The project received R50 000 in funding.

“The study is perfectly timed amid the COVID-19 pandemic, which has resulted in large-scale disruption of schooling as we know it.  The call for teachers and learners and the education system generally to embrace technology and use information and communication technology (ICT) to continue and restore teaching and learning in some way, has been overwhelming.” 

“Consequently, there has been an almost overnight surge in the use of mobile devices for teaching and learning in schools. Sadly, the pandemic has further exposed the digital-divide reality that not all schools, teachers, and/or learners are able to engage effectively with the technology.” 

“Therefore, this study will assist in repositioning teacher preparation to use mobile devices and applications that are relevant for the topics covered in the national Curriculum and Assessment Policy Statement (CAPS) document, starting with the subject Natural Sciences for the senior phase, which include Grades 7 to 9,” says Dr Jita, who is the principal investigator of the project and who is also responsible for the conceptualisation and overall direction of the project milestones.

Research projects that have also received funding, include: 

• IoT-based early diagnostics of mobility challenges in the elderly by Elisha Markus (CUT) and Paul Kogeda (UFS). 
• Impact of urban development on environmental sustainability: Case study of Mangaung Metropolitan municipality by Dr SA Oke (CUT) and Dr Olusola Ololade (UFS).
• Promoting inclusive pedagogies through transformative learning modalities in multicultural educational settings by Dr June Palmer (CUT) and Dr Rantsie Kgothule (UFS).
• Optimisation of imaging protocols for maxillofacial reconstructive prosthesis design and modelling by Prof Deon de Beer (CUT) and Dr Jacques Janse van Rensburg (UFS).
• LET-MI-C project (Lumbar ErecTor spinae block spread using MRI and CT) by Dr Je’nine Horn-Lodewyk (CUT) and Prof Gillian Lamacraft (UFS).  

News Archive

Is milk really so well-known, asks UFS’s Prof. Osthoff
2011-03-17

Prof. Garry Osthoff
Photo: Stephen Collett

Prof. Garry Osthoff opened a whole new world of milk to the audience in his inaugural lecture, Milk: the well-known (?) food, in our Department of Microbial, Biochemical and Food Biotechnology of the Faculty of Natural and Agricultural Sciences.

Prof. Osthoff has done his research in protein chemistry, immuno-chemistry and enzymology at the Council for Scientific and Industrial Research (CSIR) in Pretoria and post-doctoral research at the Bowman-Grey School of Medicine, North Carolina, USA. That was instrumental in establishing food chemistry at the university.
 
He is involved in chemical aspects of food, with a focus on dairy science and technology. He is also involved in the research of cheese processing as well as milk evolution and concentrated on milk evolution in his lecture. Knowledge of milk from dairy animals alone does not provide all the explanations of milk as food.
 
Some aspects he highlighted in his lecture were that milk is the first food to be utilised by young mammals and that it is custom-designed for each species. “However, mankind is an opportunist and has found ways of easy access to food by the practice of agriculture, where plants as well as animals were employed or rather exploited,” he said.
 
The cow is the best-known milk producer, but environmental conditions forced man to select other animals. In spite of breeding selection, cattle seem not to have adapted to the most extreme conditions such as high altitudes with sub-freezing temperatures, deserts and marshes.
 
Prof. Osthoff said the consumption of the milk as an adult is not natural; neither is the consumption of milk across species. This practice of mankind may often have consequences, when signs of malnutrition or diseases are noticed. Two common problems are an allergy to milk and lactose intolerance.
 
Allergies are normally the result of an immune response of the consumer to the foreign proteins found in the milk. In some cases it might help to switch from one milk source to another, such as switching from cow’s milk to goat’s milk.
 
Prof. Osthoff said lactose intolerance – the inability of adult humans to digest lactose, the milk sugar – is natural, as adults lose that ability to digest lactose. The symptoms of the condition are stomach cramps and diarrhoea. This problem is mainly found in the warmer climates of the world. This could be an indication of early passive development of dairy technology. In these regions milk could not be stored in its fresh form, but in a fermented form, in which case the lactose was pre-digested by micro-organisms, and the human population never adapted to digesting lactose in adulthood.
 
According to Prof. Osthoff, it is basically the lactose in milk that has spurred dairy technology. Its fermentation has resulted in the development of yoghurts and all the cheeses that we know. In turn, the intolerance to lactose has spurred a further technological solution: lactose-free milk is currently produced by pre-digestion of lactose with enzymes.
 
It was realised that the milks and products from different species differed in quality aspects such as keeping properties and taste. It was also realised that the nutritional properties differed as well as their effects on health. One example is the mentioned allergy against cow’s milk proteins, which may be solved by the consumption of goat’s milk. The nutritional benefits and technological processing of milk aroused an interest in more information, and it was realised that the information gained from human milk and that of the few domesticated species do not provide a complete explanation of the properties of milk as food. Of the 250 species of milk which have been studied, only the milk of humans and a few domesticated dairy animals has been studied in detail.

Media Release
15 March 2011
Issued by: Lacea Loader
Director: Strategic Communication
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za

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