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07 September 2020 | Story Andre Damons | Photo Pexels

Researchers from the University of the Free State (UFS) and the Central University of Technology (CUT) have recently learned that their research projects will be funded, with one research project even getting double the amount of funding requested. 

The research project of Dr Doors Fonternel, an MMed student working under Dr Edwin Turton in the Department of Anaesthesiology at the UFS, and Prof Ihar Yadroitsau (Igor Yadroitsev), Research Chair in Medical Product Development through Additive Manufacturing and the Faculty of Engineering, Built Environment and Information Technology at CUT, titled 3D Printed laryngoscope for endotracheal intubation, received R400 000 in funding. The project only requested half the amount, but in granting the funding, the evaluation committee was of the opinion that due to the relevance of the research and the long-term sustainability of the project, funding should be adjusted to R400 000.  

Another research project receiving R400 000 in funding, is a project by Dr Alice Brink, Senior Lecturer in the Department of Chemistry at the UFS, and Dr Tshepiso J Makhafola, Assistant Dean: Research, Innovation and Engagement and Senior Lecturer: Clinical Technology in the Faculty of Health and Environmental Sciences at CUT. The committee supported the novelty of the project and the contribution towards both applicants’ participation in the Future Professors’ Programme.
These projects are part of nine collaboration projects between researchers from the UFS and CUT that were approved for funding between 2019 and 2020. The funding ranges from R50 000 to R400 000. 

Using 3D printer technology 

Dr Fonternel says getting more funding than expected gives them the motivation to push through the obstacles presented by a project like this. 

“It is innovative and uncharted, so it helps to know that others also believe in the possibilities. Apart from the design, testing, and validation that this project aims to achieve, we are looking to broaden the scope into materials and sterilisation. We are also looking at acquiring equipment to enable the UFS to be able to design and manufacture devices of similar need and purpose,” says Dr Fonternel.

According to Dr Fonternel, who designed, developed, and then prototyped the video laryngoscope with the help of the Product Development and Testing Station (PDTS) at CUT, he hopes that with this new research, the validated technology of video laryngoscopy could be provided to a much larger medical community.

Prof Yadroitsau’s role is the overall project management, mechanical testing, project analysis, and possible additional fundraising.

“This can be beneficial to rural hospitals and centres with limited funds and equipment and can make a difference in the quality of care we provide to our patients. It has the potential to improve the safety of patients and healthcare workers in our current COVID-19 battle by bringing First World technology to the front line.” 

Valuable contribution to cancer research

Drs Brink and Makhafola will be collaborating on the development and testing of organometallic complexes, primarily model pharmaceuticals that can carry a radioactive metal centre. Their collaboration will develop model lead compounds and then test their biological activity, particularly for anticancer and antimicrobial activities, including toxicological profiling to determine if it is a viable option for future cancer treatment. 

“Drug development has significant challenges, particularly for academic institutions that do not have access to the focused and integrated specialty networks as developed by Big Pharma such as Roche, Novartis, Bayer, etc.  The research and development pathway of a new pharmaceutical agent that becomes commercially available, takes on average 12 years and costs approximately £1,15 bn.”

“For every single drug that receives approval, an estimated 10 000 compounds have been considered as viable options but have failed for one reason or another. Our research collaboration focuses on addressing these two main challenges that hinder academia from successfully entering the drug market.  We hope to identify potential lead compounds with novel mechanisms of action for the development of cancer therapeutics,” says Dr Brink.

This collaborative team hopes to promote and make a valuable contribution to cancer research, specifically towards the discovery of new effective cancer treatments/drugs. 

New ways of imaging patients with rheumatoid arthritis

Dr Evbuomwan Osayande, a nuclear medicine specialist at the UFS/Universitas Academic Hospital, says his research will compare the efficacy of EC-DG (ethylenedicysteine-deoxyglucose) imaging with ultrasound imaging in patients with rheumatoid arthritis. At this stage, the research is still in the protocol phase. A protocol has been submitted to the Health Sciences Research Ethics Committee of the UFS for approval. The project received R350 000. 

“If this imaging modality proves to be highly accurate and can detect disease activity, including low disease activity, much earlier than other investigational tools, it might become a routine imaging modality in the management of patients with rheumatoid arthritis,” says Dr Osayande, the principal investigator in this research.

If we can detect low disease activity with the EC-DG imaging, says Dr Osayande, it will ensure that the rheumatologists will continue patient treatment and thus prevent them from having complications, such as bone erosions and joint destruction. “It is an exciting project and we are all looking forward to the outcome.”

Embracing 4IR

The research project of Dr Thuthukile Jita, Senior Lecturer in the UFS School of Education Studies, and Dr Carlie Luzaan Schlebusch from CUT, investigates the possibilities and affordances of training student teachers to embrace the Fourth Industrial Revolution, specifically by learning to teach Science in schools using mobile devices and mobile apps. The project received R50 000 in funding.

“The study is perfectly timed amid the COVID-19 pandemic, which has resulted in large-scale disruption of schooling as we know it.  The call for teachers and learners and the education system generally to embrace technology and use information and communication technology (ICT) to continue and restore teaching and learning in some way, has been overwhelming.” 

“Consequently, there has been an almost overnight surge in the use of mobile devices for teaching and learning in schools. Sadly, the pandemic has further exposed the digital-divide reality that not all schools, teachers, and/or learners are able to engage effectively with the technology.” 

“Therefore, this study will assist in repositioning teacher preparation to use mobile devices and applications that are relevant for the topics covered in the national Curriculum and Assessment Policy Statement (CAPS) document, starting with the subject Natural Sciences for the senior phase, which include Grades 7 to 9,” says Dr Jita, who is the principal investigator of the project and who is also responsible for the conceptualisation and overall direction of the project milestones.

Research projects that have also received funding, include: 

• IoT-based early diagnostics of mobility challenges in the elderly by Elisha Markus (CUT) and Paul Kogeda (UFS). 
• Impact of urban development on environmental sustainability: Case study of Mangaung Metropolitan municipality by Dr SA Oke (CUT) and Dr Olusola Ololade (UFS).
• Promoting inclusive pedagogies through transformative learning modalities in multicultural educational settings by Dr June Palmer (CUT) and Dr Rantsie Kgothule (UFS).
• Optimisation of imaging protocols for maxillofacial reconstructive prosthesis design and modelling by Prof Deon de Beer (CUT) and Dr Jacques Janse van Rensburg (UFS).
• LET-MI-C project (Lumbar ErecTor spinae block spread using MRI and CT) by Dr Je’nine Horn-Lodewyk (CUT) and Prof Gillian Lamacraft (UFS).  

News Archive

During 2011: Prestige Scholars Programme (PSP)
2011-12-01

The University has designed the Vice-Chancellor’s Prestige Scholars Programme (PSP) to promote and support the intellectual breadth and depth required of young scholars to pose questions and generate knowledge in their disciplines and hence to occupy the vanguards of contemporary intellectual enquiry. The programme specifically targets members of the academic staff who are near completion, or have newly completed, their doctoral studies.

The goal is to select no more than 100 of the most promising young scholars and to make substantial investments in their development towards becoming full professors. A tailored, intensive programme of support is designated that combines international placement working alongside leading scholars in the discipline of the prestige scholar, with intensive mentorship and support from within the university.

 Description: 2011 PSP_Thuthuka  Tags: 2011 PSP_Thuthuka

Elite young scholars on the Vice-Chancellor’s Prestige Scholars Programme generated R1,2 million in National Research Foundation Thuthuka and Blue Skies funding in 2011 alone. Dr Katinka de Wet in the Department of Sociology was awarded Blue Skies funding for her work on the Hybrid Identity of the HIV/Aids patient. Thuthuka Grant holders Drs Cilliers van den Berg, Olihile Sebolai, Dirk Opperman and Diaan van der Westhuizen work in the fields of German and Afrikaans trauma literature, microbiology, structural and evolutionary biology, and architecture, respectively. This broad disciplinary range typifies the depth and extraordinary range of scholarship present among junior academics at the UFS.


 Description: 2011 PSP_Liza Coetsee Tags: 2011 PSP_Liza Coetsee

Dr Liza Coetsee, a Y2-rated physicist, is the first of the Vice-Chancellor’s elite cohort of Prestige Scholars to submit for National Research Foundation rating. Dr Coetsee works on the latest of the Nanotechnology Surface Science systems housed in our Department of Physics. As Prestige Scholar, Dr Coetsee conducts research on phosphor solar cells. Her aim is to establish a new Phosphor Solar Cell field at the University of the Free State with Proff. Hendrik Swart and Koos Terblans. As a member of the Prestige Scholar Programme, Dr Coetsee will work in collaboration both with colleagues from the Nelson Mandela Metropolitan University and Prof. Eray Aydil from the University of Minnesota and Editor-in-Chief of the Journal of Vacuum Science & Technology.


 Description: 2011 PSP_Olihile Sebolai Tags: 2011 PSP_Olihile Sebolai

Dr Olihile Sebolai is one of the 2 Vice-Chancellor’s elite Prestige Scholars and a microbiologist. In 2011, Dr Sebolai was awarded a Thuthuka Grant for his research on the yeast pathogen Cryptococcus neoformans, the cause of life-threatening Aids-defining illnesses such as meningitis. Dr Sebolai considers how cryptococcal lipids mediate infectious processes leading to illness. An understanding of these cellular processes will offer hope for future drug development to combat the scourge of cryptococcal meningitis, annually causing the death of over half a million people in Sub-Saharan Africa. Dr Sebolai is also interested in mapping the prevalence and distribution pattern of cryptococcal meningitis in the Free State. This, in turn, will assist health authorities to manage current infections and plan appropriately for potential outbreaks. The Prestige Scholars Programme, with the assistance of the National Research Foundation, will afford Dr Sebolai the opportunity to pursue his research in laboratories in the United States and India in 2012 and 2013.


 Description: 2011 PSP_Louis Holtzhausen Tags: 2011 PSP_Louis Holtzhausen

Dr Louis Holtzhausen, member of the Vice-Chancellor’s Prestige Scholars Programme, has been named by the South African Sports Confederation and Olympic Committee (SASCOC) as team doctor for Team South Africa during the All Africa Games, the largest sports event in Africa. National teams from African countries participated in 23 sports events. As an esteemed South African academic in sports medicine Dr Holtzhausens’ participation was an extension of the work already being done under his supervision at the UFS’s Sports Performance Unit. Many of the athletes who prepared at the Unit were also part of the team. Elite athletes’ illness and injury profiles are one of Dr Holtzhausens’ research focus areas. The exposure to this group in competition was of great value in the identification and development of research niche areas.


 Description: 2011 PSP_ Chantel Swart Tags: 2011 PSP_ Chantel Swart

The South African Society for Microbiology awarded Dr Chantel Swart-Pistor, a Prestige Scholar on the Vice-Chancellor’s elite programme, the top prize for her PhD during a recent gala dinner in Cape Town. Dr Swart-Pistor accomplished a breakthrough in the field of nanotechnology with The influence of mitochondrial inhibitors on zoospore and ascospore development. Her supervisor, Prof. Lodewyk Kock and co-supervisors, Dr Carolina Pohl and Prof. Pieter van Wyk, also stressed the important collaboration with Proff. Hendrik Swart (Physics) and Pieter van Wyk (Centre for Microscopy), which made Dr Swart-Pistor’s work possible. She has presented her work in Beijing (Medichem 2011) and Philadelphia (Biotechnology-2011). She has been invited to return to China in 2012.


 Description: 2011 PSP_ Lizette Erasmus Tags: 2011 PSP_ Lizette Erasmus

Dr Lizette Erasmus, scientific chemist and one of the Vice-Chancellor’s Prestige Scholars, has just returned from a three-month-long research visit to Prof. Hans Niemantsverdriet at the Technical University of Eindhoven in The Netherlands and the University of California, Davis. Dr Erasmus specialises in heterogeneous catalysis. Her visit to Prof. Niemantsverdriet, one of the global experts in the field of surface science, served to round of existing research. In California, Dr Erasmus visited her mentor, Prof. Bruce C. Gates, as part of the objectives of the Rector’s programme for the internationalisation of young researchers. Prof. Gates, an expert in catalysis, could contribute to Dr Erasmus’ research on the characterisation of heterogeneous catalysis and catalytic reactions. In exchange, her expertise in organometallic synthesis added value to Prof. Gates’ existing research. Their continued collaboration gave availed them of the opportunity for interdisciplinary interaction between engineering (Prof. Gates’ speciality) and chemistry, and promises to contribute to increased collaboration between the two universities in future.


 Description: 2011 PSP_Dirk Opperman Tags: 2011 PSP_Dirk Opperman

Dr Dirk Opperman, specialist in structural and evolutionary biology and National Research Foundation Thuthuka Grant holder, joined the Vice-Chancellor’s Prestige Scholars Programme after his postdoctoral work at the Max Planck Institute (KOFO) in Germany. Dr Opperman is the recipient of institutional seed funding to establish a protein crystallisation unit, which in turn led to the donation in 2011 of a multi-million Rand X-ray diffractometer¬ from the University of the Western Cape to complement his existing access to international synchrotrons. Dr Opperman is spending part of 2011 at the University of Exeter (UK) to further his research into the three-dimensional structures of specific enzymes and their trajectories of evolution to specific functions.


 Description: 2011 PSP_Abiodun Ogundeji Tags: 2011 PSP_Abiodun Ogundeji

Abiodun Ogundeji is a member of the Vice-Chancellor's Prestige Scholars Programme. Abiodun's work was recently recognised when he and his co-authors received an award for the best contributed paper at the 49th annual conference of the Agricultural Economics Association of South Africa on the topic, Impact of climate change on planning and dealing with flood disasters in South Africa: A case study of Soweto on Sea. The paper was co-authored by Prof. Giel Viljoen from our Department of Agricultural Economics and Herman Booysen, as well as Gawie du T. de Villiers, Research Associates in the Department of Geography. Abiodun is currently conducting invaluable research on the quantification of the economic value of climate change impacts and the benefits and costs of adaptation in South Africa.

 

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