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11 August 2021 | Story Dr Cindé Greyling | Photo Supplied
Art lover Prof Janine Allen-Spies

Prof Janine Allen-Spies is an artist, lecturer in Fine Arts, and image philosopher from the UFS Department of Fine Arts. She teaches painting, drawing, and conceptual art to pre-graduate students and supervises postgraduate students in Fine Arts and other creative practices. In 2020, she was awarded the Stals Prize for her valuable role as a visual artist, academic, mentor, lecturer, activist, and supporter of art. 

What is the best thing about your job?
Working with artists and students who are energetic and passionate and love talking about art. 

What is the best and worst decision you have ever made?
As a second-year Art student, I modelled a psychedelic-looking bikini at a vintage clothing fashion show. Still makes me cringe! The best decisions weren’t really mine – they were godly interventions, so I can't claim them.

What was/is the biggest challenge of your career?
The biggest challenge is to make art. Even in the best circumstances, artmaking is ecstasy and agony. My biggest challenge as a mom is that I have two teenagers at home – working with students doesn't mean you know anything about younger teenagers.

What does the word woman mean to you?
As one of six sisters, I learnt that ‘woman’ implies diversity. We are all entirely different. Luckily, I don't have any preconceived ideas; all people should strive to be full-bodied human beings.

Which woman inspires you, and why?
Hypatia of Alexandria, Emily Hobhouse, Frida Kahlo, Princess Diana, and Caster Semenya – all women who do not fit into any mould. I am also inspired by my friends and my sisters and a lot of other local women.

What advice would you give to the 15-year-old you?
Make more of an effort to not grow up! Enjoy the beach, because one day you will not live close by. Your body is your own to take responsibility for and to love. Be strict with boyfriends and learn how and when to end a relationship, because nobody teaches you that.

What is the one self-care thing that you do? 
At the moment, the selfcare thing is visiting Nick, the hairdresser of Bella Donna who can fix, colour, and cut my hair, because managing my hair myself is just impossible.

What makes you a woman of quality, impact, and care?
I try to be self-reflective. To forgive and to be accepting are very important; we all have our fault lines, and we should work with each other's shortcomings. 
 
I cannot live without … coffee and ‘my’ psychologist.
My secret weapon is … honesty, and if my honesty fails, it will be having a Plan B.
I always have … fashion clothing items, even if I must make or alter clothing myself. My grandmother was a seamstress and we learnt to love clothing design.
I will never … again take the Free State landscape for granted.
I hope … poverty in the country will be addressed aggressively and in a more directed manner – which 
includes active participation and engagement of all people in South Africa.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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