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15 December 2021 | Story Nondsindiso Qwabe | Photo Supplied
Bachelor of Education third-year student, Moeketsi ‘Escalator’ Ngesemane.

By day he is a third-year Bachelor of Education student on the Qwaqwa Campus, but this young man is a Sesotho music maestro with a deep-rooted passion for traditional music and a diligent devotion to unearthing new talent and connecting more people to the cultural artistry that Sesotho music has to offer.

Moeketsi Ngesemane, better known as ‘Escalator’ in the world of music, is only 22 years old, but he has already released one solo album and featured in two more, leads a group of more than 80 traditional singers and dancers, and is responsible for a string of groups around Qwaqwa. He has made strides far beyond his age, and Ngesemane says he is only getting started. He was also instrumental in coordinating the Qwaqwa traditional groups that performed during this year’s Multilingual Mokete festival, where he also featured.

Born and bred in Qwaqwa, Ngesemane pins his love for traditional music as something that was cultivated in his childhood while singing traditional songs with his mother and brother. “My mother is a traditional healer, so Sesotho music was a big part of my upbringing. As I grew older, my brother and I would perform in town and people would give us money. I have not looked back since.”

He cemented himself as an artist and artist manager in his first year in 2009. The name ‘Escalator’ came about in an uncanny way, as he fondly recalls. “I had a friend who was afraid of escalators when he first saw it – but I wasn’t, so he named me ‘Escalator’. I hated the name until I personalised the meaning behind it. It is able to take people from one point to another and from one level to another, which is something I am passionate about doing through traditional music, so the name was fitting.”

He captivated the minds and hearts of both young and old people who want to be under his leadership, and he grooms young people as young as ten, who will also thrive and take traditional praise singing and dancing to greater heights. This, he says, helps him alleviate some responsibilities so that he can focus on his schoolwork.

Celebrating the Sesotho culture through music

Word about his music skill often spreads quickly. “Even when I am on teaching practicals at different schools, once learners find out what I do, they ask to join my group and I can’t say no. Their ages range from 7 to 21, and I know that my group will have more than 100 members before the year ends,” he said.

He often puts together music shows with his group around Qwaqwa. This, he says, he does to promote Sesotho music and art.

Ngesemane has been selected to represent the Basotho Kingdom at the Indoni Mr and Miss Cultural South Africa – an indigenous event focused on promoting South Africa’s diverse cultural heritage, taking place at the Durban ICC on 17 December. He describes this as a dream come true.

“It’s a great honour to be representing the Basotho culture. I have discovered that young people, especially, have neglected their cultural roots and often look down on traditional music and regalia. I’ve made it my personal aim to promote and uphold the Sesotho culture through praise singing and dancing.”

You can vote for Ngesemane by SMS’ing ‘Indoni Mr Sotho’ to 33616.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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