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12 February 2021 | Story Leonie Bolleurs | Photo Charl Devenish
Dr Alice Ncube says that since coming to South Africa and working with vulnerable communities in the disaster (risk) management field, she has gained extensive knowledge and perspectives on the real-life situations of humanity.

While working in human resources and industrial-relations management portfolios, Dr Alice Ncube saw a window of opportunity to get into research, focusing on the challenges that was threatening the human capital management sectors and the general operations of governments and the private sector. 

Today, Dr Ncube is teaching students and doing research in the Disaster Management Training and Education Centre (DiMTEC) at the University of the Free State (UFS), where she is a Senior Lecturer and Programme Director.

On 11 February – International Day of Women and Girls in Science – the UFS is celebrating Dr Ncube, who chose to be a scientist due to her desire to make a difference. 

Being a migrant facing several challenges in her host country motivated her to do her PhD on international migration, specifically on women from developing countries to other developing countries such as South Africa.

Her research also covers related topics, including social vulnerability and resilience, international forced migration, gender issues, climate change and adaptation, and sustainable livelihoods of disadvantaged communities.

Demystifying perceptions

“Many persons who do not reside in the country believe that South Africa is a land of opportunities – socially, politically, and economically – due to its position on the African continent. This all-round positive picture of the country painted to the outside world is the main reason for the huge inflow of migrants into the country,” believes Dr Ncube. 

She envisaged that her study would assist in demystifying the perception that migrants are those who come to a host country to take local jobs and put pressure on local resources.

“I felt that gender migration in this space is under-researched, particularly migration of women. Migration is not gender neutral, but gender biased, as evidenced by the 1960s and early 1970s, where terms such as ‘migrants and their families’ were coded to refer to male migrants and their wives and children. Although women were nearly invisible, there is evidence of them migrating as independent agencies and also taking along their families, including husbands,” she explains.

Exploring the coping and adaptation strategies that women employ in the host country, she found that although faced with many challenges, the migrant women cope and adapt well.

Her research as well as her work of more than 10 years with the vulnerable communities, including migrants, has established that the resilience of vulnerable communities is bigger than the intervention strategies that governments and other stakeholders envisage.

People are hungry for knowledge that will better their lives. – Dr Alice Ncube

Impacting lives

“Since coming to South Africa and working with vulnerable communities in the disaster (risk) management field, I have gained extensive knowledge and perspectives on the real-life situations of humanity, let alone in our continent and region,” she says.

She has worked with government departments at local, district, provincial, and national levels in an effort to change the conditions faced by poor, marginalised, and disadvantaged communities. Dr Ncube was also involved in community capacity-building activities through short courses and short learning programmes. 

She considers the training she has presented as one of the biggest achievements of her life. “People are hungry for knowledge that will better their lives.” 

“This has been so fulfilling to me as I have made an impact on the lives of the people,” says Dr Ncube.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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