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11 February 2021 | Story Leonie Bolleurs | Photo Ané van der Merwe
Dr Ismari van der Merwe was instrumental in establishing the new Department of Sustainable Food Systems and Development.

Dr Ismari van der Merwe believes that by forging strong relationships, women can affect virtually every aspect of their students' lives, teaching them vital life lessons that will help them succeed beyond term papers and standardised tests. 

She states that it is not always easy to change a student's life, so it takes a great teacher to do so. “You, as a teacher, have a very significant, lifelong impact on all your students. This impact involves not only the teaching of particular academic skills, but as importantly, the fostering of student self-esteem.”

“Reinforcing self-esteem in the classroom is associated with increased motivation and learning,” she says.

Dr Van der Merwe is Lecturer and Programme Director in the Department of Sustainable Food Systems and Development at the University of the Free State (UFS).

On 11 February – International Day of Women and Girls in Science – the UFS is celebrating her not only for the impact she has on her students, but also for being instrumental in establishing the new Department of Sustainable Food Systems and Development, putting the UFS on the international forefront.

A sustainable food system

“We want our students to be part of a sustainable food system that provides healthy food that meets food needs, while maintaining healthy ecosystems that can also provide food for generations to come, with minimal negative impact to the environment,” she says. 

“The right to food is a fundamental human right.”

Dr Van der Merwe believes that a healthy personal food system and how it is managed is now more critical than ever before. 

Her current work involves managing the five main food-related values of taste, health, cost, time, and social relationships, as well as other less prominent values of symbolism, ethics, variety, safety, waste, and quality within these personal food systems. She feels the prominence of these values varies among us as well as across our eating situations. “More research on this will be fascinating,” says Dr Van der Merwe. 

A male-dominated field

On the role of women in science, Dr Van der Merwe says it is often considered a male-dominated field. “According to United Nations data, less than 30% of scientific researchers worldwide are women,” she states.

Telling her story about becoming a scientist, she says that science chose her. “Many scientists have reported that their interest and curiosity in science or the natural world started in early childhood.”

We want our students to be part of a sustainable food system that provides healthy food that meets food needs, while maintaining healthy ecosystems that can also provide food for generations to come, with minimal negative impact to the environment. – Dr Ismari van der Merwe

 

“I started as a teacher and ended up working for the Agricultural Research Council, where I was responsible for a research programme on dry beans and started a small-scale research factory.”

“Later when we moved to Bloemfontein, I joined the UFS. Here I am privileged to be able to do research and teach. Science chose me as part of my life journey, and I never looked back.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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