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15 February 2021 | Story Supplied | Photo Supplied
Dr João Vidal is a research fellow at the Department of Plant Sciences and the Afromontane Research Unit (ARU) at the University of the Free State (UFS).

According to United Nations data projections for 2100, sub-Saharan Africa is set to experience a demographic explosion. The most rapid population growth zones in Africa are in or around mountains and the importance of managing these mountain ecosystems sustainably in order to maintain the benefits to such a growing population is critical, says Dr João Vidal, a research fellow at the Department of Plant Sciences and the Afromontane Research Unit (ARU) at the University of the Free State (UFS). 

The link between human population growth and the demand for water will impact these mountain grasslands. All of Africa’s important rivers originate in mountainous areas. The sustainable management of African mountain landscapes is thus vital for the sustained provision of quality water in suitable quantities. “Water is already limited in some places. This year we are facing another drought in South Africa, and if it was not for the mountains, it could have been much worse. The long-term resilience of Southern Africa’s mountains and their ecosystem services should be an absolute priority for both research and conservation,” says Dr Vidal.

Human population growth has several implications

As a mountain ecologist, his recent research is centred on developing indicators for monitoring biodiversity change in Southern Africa’s mountains. This is a collaborative research project with the South African Environmental Observation Network (SAEON), Ezemvelo KZN Wildlife, and the University of Pretoria.

Human population growth, as predicted for Southern Africa, has several implications for natural-resource management and biodiversity conservation. “Southern Africa has one of the highest proportions of grassland-dominated mountains in the world, comparable only to Central Asia,” says Dr Vidal. 

In December, UN Secretary-General António Guterres said during the launch of the 2021 Global Humanitarian Overview: “Conflict, climate change and COVID-19 have created the greatest humanitarian challenge since the Second World War. The number of people at risk of starvation has doubled. Hundreds of millions of children are out of school. Levels of extreme poverty have risen for the first time in 22 years.”

According to Dr Vidal this new scenario significantly increases the pressure on mountain environments and their biota, since people will have to find alternative ways of feeding their families, their animals, while the economy struggles to recover globally.

Through his research, Dr Vidal – together with a growing community of practices for Southern Africa’s mountains – aims to understand the socio-ecological functioning of these montane grasslands in order to encourage a science-policy-action interface for their sustainable management in a changing world. 


Alternative ways for measuring environmental change in mountains

Since much global mountain research is focused on forest-dominated mountains, Dr Vidal and his collaborators are developing specific tools to track climate change in grassy mountains.
He explains: “When you look at the available tools for tracking climate change in mountains, you have a tree line for many mountains in the world. However, with the Southern African grassy mountains, it is impossible to use such a tool. We are working on alternative ways for measuring environmental change in our mountains.

“As it gets warmer, certain communities of grasses may retract towards higher elevations because they need a certain minimum temperature to survive. The problem seems to be that current climate change is occurring at a much faster rate than most species might be able to retract. This means that higher temperatures may lead to habitat losses for temperature-vulnerable groups.

“Climate change is also making mountains increasingly vulnerable to ecological invasion by non-native species. The severe temperatures in mountains are a good barrier for many problematic lowland species. But with warmer temperatures in the mountains, these barriers are being weakened, increasing the number of potentially invasive plants in our mountains. With higher temperatures there is potential for a large guild of invasive trees to overrun grassland mountains affecting waterflow into dams and rivers. Examples are pines, willows, gums, and wattles, to name a few.

“The presence of invasive trees, especially along rivers, has long-term negative impacts on the functioning of mountain catchments. These trees destabilise riverbanks, extract large amounts of water, and cause local extinction of endemic montane biodiversity. In drier environments such as grasslands, this exacerbates the fragile water productivity,” he adds.

Global policymakers to recognise the value of grassy mountains 

It is important to draw attention to the value of natural grassy mountain systems around the world and to how threatened they are. The world’s grassy mountains need to be better studied and better placed on the global stage. This will encourage policy makers to recognise these systems and implement appropriate measures to facilitate their sustainable management. 

For the first time in 20 years, the recent International Panel of Climate Change (IPCC) report to the United Nations included a chapter focusing solely on mountains. “Policymakers are finally realising how disproportionately important mountain environments are and how dramatically they are affected by climate change,” says Dr Vidal. 

However, African mountains are underrepresented in research literature; it is the only continent for which there is no data included in the IPCC report. There is an urgent need to represent African mountains – especially Southern Africa’s mountains – on the global stage when it comes to climate change,” states Dr Vidal.

Dr Vidal is conducting this study in partnership with Dr Ralph Clark, Director of the ARU on the UFS Qwaqwa Campus

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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