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04 January 2021 | Story Igno van Niekerk | Photo Francois van Vuuren (iFlair)
Anton Roodt

 The Afrikaans words, weerlose meganika, can be roughly translated as ‘vulnerable mechanics’. If you do not know the exact meaning of this, rest assured, you are not alone. At least one person does. Anton Roodt of Roodt Architects has been summoning a storm of positive reviews in the literary world with his debut offering, which is neither an environmentally friendly building nor creative historical restoration for which he is renowned, but a book.

Weerlose meganika was written as part of the requirements for Roodt’s fourth MA degree – all obtained at the University of the Free State (UFS), where the Roodts have been part of the UFS family for three generations. Anton’s father was the Head of the department of Architecture, and his son recently completed his studies in the same department. His wife, Zarine, has been involved as lecturer and research fellow in the Department of Communication Science. Roodt’s wide spectrum of interests shows in the variety of his MA degrees (Architecture, Town and Regional Planning, Environmental Management, and now – Creative Writing).

Roodt, renowned for his creativity and innovative manner of working, has barely stepped into the world of literature; yet the book, published by Tafelberg Publishers, is being described in words probably never used by critics: “verrassend vernuwend” (surprisingly refreshing), “baldadig,” (which I can only translate as ‘wildly playful’), and nostalgic science fiction.

In a Zoom conversation, Roodt shared that he wrote mostly in his spare time. Many hours of study in the buzz of architecture classrooms taught him to focus anywhere and anytime. According to Roodt, the chapters that had to be removed in the final edits of Weerlose meganika comprise sufficient material for a second book. 

Anton and his son, Leon-Pierre, both worked on the cover of Weerlose meganika: Anton designed it and Leon-Pierre was responsible for the graphics. Although publishers usually prefer to appoint their own designers, Tafelberg liked and kept the design as presented. This was no surprise, as design is not new to Anton who, as a student, was involved in the design of rag posters. During a particular rag, he realised that the poster design was extremely successful, as about 90% of them were stolen by students from lampposts and other areas. 

Roodt’s recipe for success? He is naturally curious and wants to learn more about many things. This allows him to connect with interesting people such as his fellow students and lecturers (Dr Francois Smith and Prof Henning Pieterse) in the Creative Writing course, where they kept on pushing each other to improve their work. It is clear that Roodt is on a lifelong journey of learning. And, in case you are wondering – yes, he recently started his PhD studies. At the UFS, of course.

When I asked Anton about the strange title, Weerlose meganika, he explained that he has always been fascinated by juxtapositions. He loves bringing seemingly unrelated elements together. 

Looking at the reviews, he has been successful once again. 

*** If you are curious to know more, Weerlose meganika is available at most bookstores, as well as online.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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