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26 July 2021 | Story Nonsindiso Qwabe | Photo Nonsindiso Qwabe
On top of the Drakensberg. The ARU and Witsieshoek Mountain Lodge research team are, from the left: Grant Martin, Dr Ralph Clark, Jan van Niekerk, Prof Aliza le Roux, Prof Peter Taylor, and Dr Sandy Steenhuisen.

All mountains around the world have native and non-native species that are expanding their ranges quite dramatically; however, little research has been conducted towards understanding the long-term redistribution of species and the effects of global change on biodiversity.


The Afromontane Research Unit (ARU) on the University of the Free State Qwaqwa Campus – as part of the Mountain Invasion Research Network – has secured a two-year EU Horizon 2020 project under the Department of Science and Innovation, which will be looking at the mechanisms underlying the success and impact of range-expanding species on biodiversity and ecosystem functioning.

On Monday 19 July 2021, the ARU took a few of its researchers on a scenic helicopter ride to the summit of the Drakensberg for an alpine field-experiment site inspection of the Mont-aux-Sources peak, one of the highest sections of the Drakensberg range. This site has been identified for the project which the research unit will be leading on mountain research.

ARU Director, Dr Ralph Clark, said the project would explore the effects of global change, biological invasions (when species invade new geographic regions), as well as climate and land-use change. He said experiments were needed to explore the various possibilities and to test the extent to which species respond to experimental treatments. The project would therefore be conducting experiments for two years using open-top chambers – causing an increase in temperature of 3 or 4 degrees to what you find naturally – on plant species from lower down to the top of the mountain, to see how they function. “This will give us an idea of whether they will be able to survive in global warming scenarios. If temperatures get warmer, we might start seeing a lot of plants up here that we wouldn’t otherwise find here.”

Dr Clark said little is known about the long-term monitoring of species distribution and the effects of global change. Implementing the project in the Maloti-Drakensberg alpine area will therefore put the area in the global mountain research arena. The elevational gradient in the Maloti-Drakensberg Mountains provides space to explore the key processes underlying the variation in species elevation with climate change. “One of the things we don’t know much about are alpine systems. We are hoping to establish a long-term alpine research site and try to add as many studies as we can. The more science we can bring up here, the more we can know about mountain life. What happens on mountains has a lot of impact on social dynamics.

“This project is looking to see what is driving range expansion. Every mountain has its own context. In the Swiss alpine, fires are not a big factor, but fires are one of the biggest factors on our mountains. Some of our native and non-native species are therefore fire-driven, so as fire increases, you might have them spreading faster.”

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UFS cardiac team leading with project
2017-05-31

 Description: Cardiac team read more Tags: Cardiac team read more

Prof Peter Schultheiss of the Charité University in Berlin,
Germany, visited the Robert WM Frater Centre for
Cardiovascular Research at the UFS for a study regarding
cardiomyopathy, a significant cause of fatal heart failure
among Africans. From the left are Dr Glen Taylor,
Dr Danie Buys, Prof Makoali Makatoko,
Prof Schultheiss and Prof Francis Smit.
Photo: Rulanzen Martin

A team of cardiac doctors associated with the Robert WM Frater Cardiovascular Research Centre at the University of the Free State’s (UFS) Faculty of Health Sciences has commenced with a pioneering research project regarding idiopathic dilating cardiomyopathy.  

An Afrocentric research focus
Prof Francis Smit, Head of the Department of Cardiothoracic Surgery at the UFS and Head of the Frater Centre, describes dilating cardiomyopathy as a heart muscle disease that is quite common, particularly among people of African descent. The disease weakens the heart muscle, which in turn leads to heart failure.

“To date there is no curable treatment for this condition and 50% of patients that have shown heart failure, died within a period of five years. The causes of this condition have been unknown in the majority of patients. But over the past few years major strides have been made where virus infections of the heart muscle or myocarditis have been identified as a possible underlying cause. Various genetic diseases are also linked to it,” says Prof Smit.

International collaborations ensure success
According to Prof Smit, the project is being run in conjunction with Prof Heinz-Peter Schultheiss of the Charité University and the Institute for Cardiac Diagnostics and Therapy in Berlin, Germany.

“We have been working on the project over the past 18 months and I have twice visited Prof Schultheiss in Germany. He is now visiting us in Bloemfontein. We have established a collaborative project focused on patients in central South Africa”.
Prof Schultheiss is a world leader regarding the diagnosis, pathology and treatment of dilating cardiomyopathy, says Prof Smit.

“He brings a lifetime of research experience to Bloemfontein and is internationally renowned as the father of myocardial or heart muscle biopsies.

“His pioneering work on the discipline has led to diagnostic accuracy that has induced purposeful and personalised treatment of dilating cardiomyopathy and has brought about dramatic changes in some subsets of patients’ life expectancy and their cure.”

Solving problems close to home
According to Prof Mokoali Makatoko, Head of the Department of Cardiology, there are more than 1500 new cases of heart failure identified annually at the Universitas Academic Hospital, of which approximately 30% are attributed to cardiomyopathy. “With the use of endomyocardial biopsies the team hopes to treat viruses unique to Southern Africa as well as other underlying causes of dilating cardiomyopathy.”

Prof Stephen Brown, Head of Paediatric Cardiology at the Universitas Academic Hospital, says children suffering from this disease never reach a mature age and those under his supervision will also be undergoing these tests. Various other departments at the UFS will also participate in this project. Profs Makatoko and Brown did the first four endomyocardial biopsies under the management of Prof Schultheiss during the past week. The results will be available in the coming weeks after which the project will be officially launched and patient recruitment will start in earnest.

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