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23 August 2022 | Story André Damons | Photo Supplied
Dr Walter Janse van Rensburg
Dr Walter Janse van Rensburg, Senior Lecturer in the Human Molecular Biology Unit, Department of Haematology and Cell Biology in the UFS School of Biomedical Sciences, says new research found that men of European descent over the age of 50 are the most vulnerable for the development of atherosclerosis.

A new study by researchers in the Human Molecular Biology Unit in the School of Biomedical Sciences at the University of the Free State (UFS) into atherosclerosis in the South African population found that men of European descent over the age of 50 are the most vulnerable for the development of atherosclerosis – the most common disorder associated with cardiovascular diseases (CVDs). Nearly half of men in this group had visible signs of atherosclerosis in the coronary arteries of the heart. 

This was in contrast to the only roughly one-tenth of the African-descent males and females in the same age bracket. More than a third of women of European descent over 50 had visible atherosclerosis in their coronary arteries. One hypothesis regarding a possible explanation for this discrepancy is based on the theory that socioeconomic status may be a driving force behind CVD.

Risks factor for cardiovascular diseases

Dr Walter Janse van Rensburg, Senior Lecturer in the Human Molecular Biology Unit at the School of Biomedical Sciences, UFS, and principal researcher, says the study was conceptualised during 2020s COVID-19 pandemic, due to reports of excessive blood clots associated with both acute COVID-19 infection and some of the SARS-CoV2 vaccines. However, limited data existed in our region regarding the other underlying causes for blood clot formation, such as atherosclerotic plaque rupture. The data was collected during a couple of months in 2021. The data was collected out of more than 10,000 case files spanning 10 years. The study is still ongoing.

“Atherosclerosis remains a major risk factor for CVD, and thus, believed to be a good indicator of the CVD profile in a population, yet little is known on its prevalence in sub-Saharan African populations. We aimed to determine the prevalence of atherosclerosis in a diverse South African population as found in post-mortem investigations. A retrospective file audit was done on 10,240 forensic post-mortem reports done at a forensic pathology mortuary in South Africa, over 10 years,” writes Dr Janse van Rensburg in the Abstract of the research article. 

According to him, cardiovascular diseases are reportedly the No 1 cause of mortality worldwide. According to the latest report from Stats SA, diseases of the circulatory system account for nearly a fifth of all deaths in South Africa.
“CVD is a multifactorial disorder, however, the presence of atherosclerosis (an inflammatory condition of artery walls) is the most common disorder associated with CVD. In order to assist in the prevention of the formation and progression of atherosclerosis, one can manage factors that have been associated with a higher risk for atherosclerosis, such as the use of tobacco, hypertension, elevated cholesterol, obesity, HIV infection and diabetes,” says Dr Janse van Rensburg.

Reasons behind different population’s mortality rate

It has been proposed, says Dr Janse van Rensburg, that socioeconomic status is possibly one of the essential roleplayers in CVD aetiology. The socioeconomic inequality in South Africa is well known, with an economic inequality Gini coefficient of 0.63 (the highest in the world). One study reported that in the Free State province, in the non-agricultural sector, the average household income for a European-descent household is roughly 4.35-times higher than the average African-descent household income. 

“Therefore, it is postulated that wealthier people, in the South African context, historically people of European descent, have the means to afford and adopt lifestyles that contribute to the increased risk of lifestyle diseases such as obesity, hypercholesterolaemia and diabetes, which are associated with a higher risk to develop CVD.

“We postulate that CVD-related deaths are traditionally lower among South Africans of African descent compared to the other ethnic populations due to the historical socioeconomic discrepancy between people of African descent and other population groups in higher-income countries.”

The study also found that the prevalence of CVDs and the incidence of premature CVD-related deaths are steadily increasing in both rural and urban communities and across the socioeconomic spectrum. The theory of epidemiological transition says that in populations with improved living conditions and better access to healthcare, the proportion of deaths caused by infectious diseases will decrease, and the proportion of deaths due to more chronic “man-made” lifestyle-related diseases, such as CVD, will increase.

However, our population’s socioeconomic status is not the only driving force behind CVD. Therefore, we theorise there has been an upward trend in South Africa across all regions to improve the access to better food and better healthcare, consequently resulting in an increase in CVD-related morbidity and mortality statistics.

“For all population groups, males are more affected than females within their demographic group. This may also be possibly attributed to the socioeconomic status and access to the healthcare gender-gap differential in the country.”

Studies are vital in raising public awareness

Dr Janse van Rensburg says that studies such as this are vital in raising public awareness regarding disorders associated with the lifestyle choices people make. However, a multidisciplinary approach is needed to ultimately create a lasting impact. 

“We hope that our findings will assist in identifying specific groups with a possible increased risk for CVD, and that we will inspire more focused research to identify potential high-risk behaviours within these groups that may eventually result in the enhancement of public health policies and awareness campaigns in our region.

“Recently, another article has been accepted for publication regarding the prevalence of excessive blood clots (thrombosis) as the underlying cause of death in our study cohort, further contributing to our understanding of the origins and contributory factors of CVDs in our region.”

News Archive

Gender bias still rife in African Universities
2007-08-03

 

 At the lecture were, from the left: Prof. Magda Fourie (Vice-Rector: Academic Planning), Prof. Amina Mama (Chair: Gender Studies, University of Cape Town), Prof. Engela Pretorius (Vice-Dean: Humanties) and Prof. Letticia Moja (Dean: Faculty of Health Sciences).
Photo: Stephen Collett

Gender bias still rife in African Universities

Women constitute about 30% of student enrolment in African universities, and only about 6% of African professors are women. This is according to the chairperson of Gender Studies at the University of Cape Town, Prof Amina Mama.

Prof Mama was delivering a lecture on the topic “Rethinking African Universities” as part of Women’s Day celebrations at the University of the Free State (UFS) today.

She says the gender profile suggests that the majority of the women who work in African universities are not academics and researchers, but rather the providers of secretarial, cleaning, catering, student welfare and other administrative and support services.

She said that African universities continue to display profound gender bias in their students and staffing profiles and, more significantly, are deeply inequitable in their institutional and intellectual cultures. She said women find it difficult to succeed at universities as they are imbued with patriarchal values and assumptions that affect all aspects of life and learning.

She said that even though African universities have never excluded women, enrolling them presents only the first hurdle in a much longer process.

“The research evidence suggests that once women have found their way into the universities, then gender differentiations continue to arise and to affect the experience and performance of women students in numerous ways. Even within single institutions disparities manifest across the levels of the hierarchy, within and across faculties and disciplines, within and between academic and administrative roles, across generations, and vary with class and social background, marital status, parental status, and probably many more factors besides these”, she said.

She lamented the fact that there is no field of study free of gender inequalities, particularly at postgraduate levels and in the higher ranks of academics. “Although more women study the arts, social sciences and humanities, few make it to professor and their research and creative output remains less”, she said.

Prof Mama said gender gaps as far as employment of women within African universities is concerned are generally wider than in student enrolment. She said although many women are employed in junior administrative and support capacities, there continues to be gross under-representation of women among senior administrative and academic staff. She said this disparity becomes more pronounced as one moves up the ranks.

“South African universities are ahead, but they are not as radically different as their policy rhetoric might suggest. A decade and a half after the end of apartheid only three of the 23 vice-chancellors in the country are women, and women fill fewer than 30% of the senior positions (Deans, Executive Directors and Deputy Vice-Chancellors)”, she said.

She made an observation that highly qualified women accept administrative positions as opposed to academic work, thus ensuring that men continue to dominate the ranks of those defined as ‘great thinkers’ or ‘accomplished researchers’.

“Perhaps women simply make realistic career choices, opting out of academic competition with male colleagues who they can easily perceive to be systematically advantaged, not only within the institution, but also on the personal and domestic fronts, which still see most African women holding the baby, literally and figuratively”, she said

She also touched on sexual harassment and abuse which she said appears to be a commonplace on African campuses. “In contexts where sexual transactions are a pervasive feature of academic life, women who do succeed are unlikely to be perceived as having done so on the basis of merit or hard work, and may be treated with derision and disbelief”, she said.

She, however, said in spite of broader patterns of gender and class inequality in universities, public higher education remains a main route to career advancement and mobility for women in Africa.

“Women’s constrained access has therefore posed a constraint to their pursuit of more equitable and just modes of political, economic and social development, not to mention freedom from direct oppression”, she said.

Prof Mama concluded by saying, “There is a widely held agreement that there is a need to rethink our universities and to ensure that they are transformed into institutions more compatible with the democratic and social justice agendas that are now leading Africa beyond the legacies of dictatorship, conflict and economic crisis, beyond the deep social divisions and inequalities that have characterised our history”.

She said rethinking universities means asking deeper questions about gender relations within them, and taking concerted and effective action to transform these privileged bastions of higher learning so that they can fulfil their pubic mandate and promise instead of lagging behind our steadily improving laws and policies.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za  
02 August 2007
 

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