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30 August 2022 | Story André Damons | Photo André Damons
UFS Nuclear Medicine
The team of doctors in the Department of Nuclear Medicine behind the success story are, from the left (standing): Dr Osayande Evbuomwan, nuclear medicine specialist and Senior Lecturer; Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS; and Dr Walter Endres, nuclear medicine registrar. In front is Dr Tebatso Tebeila, nuclear medicine registrar.

The University of the Free State (UFS) Department of Nuclear Medicine is proud to announce the successful treatment outcome of a patient with metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer – by using Lutetium 177 PSMA (Lu-177 PSMA) therapy. This was initially a case of advanced stage prostate cancer, which had failed first-line chemotherapy, leaving little or no other treatment options.

This is a proud and happy moment for the department and the UFS, which started this treatment just over a year ago. The university and the Free State province are now joining other South African medical universities, such as the University of Pretoria, and other provinces in using this method to treat MCRPC patients. Lutetium 177 PSMA (Lu-177 PSMA) therapy is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS, says the department is proud to be able to offer this treatment option to some of these patients. “It is a big win for the Free State and our oncology patients to be able to offer these expert services.” The UFS and Universitas Academic Hospital have now been able to join up with other academic institutions and hospitals in other provinces to offer these services. So far, three patients have been offered this therapeutic option, with the third patient currently undergoing his treatment.

Funds and equipment for proper treatment selection are needed

The expertise is no longer an issue for the UFS, as Dr Osayande Evbuomwan, nuclear medicine specialist and consultant, was trained and exposed to this therapy at the University of the Witwatersrand during his training as a nuclear medicine resident. Current registrars in the Department of Nuclear Medicine at the UFS are also being trained in the application of this treatment modality. However, proper patient selection is key in the management of these cases with Lu 177 PSMA. Without a PET/CT camera, it is challenging to appropriately select the patients who are most likely to respond to this therapy. This is an example of how PET/CT is crucial in the management and monitoring of oncology patients.

Both Drs Engelbrecht and Evbuomwan hope that the training of more registrars will increase their department’s capacity to treat more patients. They also hope that funds will be made available to acquire a much-needed PET/CT camera, which will greatly assist them in identifying the correct patients in need of this treatment. 

With the permission of the patient, the images above show the dramatic treatment response following Lu-177 PSMA therapy. The images on the left show widespread bone disease from the prostate cancer, including the skull. The images on the right show the dramatic response after completing four cycles of Lu 177 PSMA, with the normal excretion of the radiotracer seen in the liver, kidneys, and bladder.


Treatment puts the department, UFS, and hospital on the map

According to Dr Evbuomwan, the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. Says he: “It also creates an avenue for us to gather data for training, research purposes, and publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients will no longer have to travel to other provinces to receive this treatment.”


“We are also well aware that not every patient will respond this way; however, proper patient selection is key in identifying responders – an area that is still being researched. We also do not know how long these patients will have their disease under control after the treatment. Nuclear medicine’s greatest cancer therapy success story is the treatment of well-differentiated thyroid cancer with radioactive iodine.” 

“After treatment, most of these patients remain cancer-free for a very long period of time, if not for life. With continuing research in the field of MCRPC radioligand therapy, we aim to improve the treatment modality, hopefully getting it to the success level of thyroid cancer therapy.”

 

News Archive

Translation Day Seminar
2007-10-22

Subverting the West? Engaging language practice as African interpretation.

With the above-mentioned title in mind, about 30 people gathered at the Main Campus of the University of the Free State (FS) in Bloemfontein for a Translation Day Seminar. The day was attended by academics, language practitioners, government departments, students, and other stakeholders in language practice.

Prof. Jackie Naudé, the Programme Director for the Programme in Language Practice at the UFS, gave a short historical overview of developments in research and training in language practice of the past decade. He argued in favour of a socio-constructivist approach to teaching and research in language practice. His point was that students need to be given the opportunity to engage with the complexities of real-life problems, specifically the complexities of the African context.

Dr Kobus Marais, Senior Lecturer in Translation Studies at the UFS, gave an overview of the state of the art of translation research. This meant that language practitioners are agents in communication, not mere conduits of meaning. He argued that translators’ agency implied that they have to make informed choices, the most important of which is whether to indigenise or foreignise when translating. He developed wisdom as a notion in translation, indicating that translators need to be wise to interpret their context and translate in such a way that (Western) ideology does not ride piggy-back on their translations into the African target culture.

Prof. Joan Connoly, Associate Professor in the Centre for Higher Education Development at Durban University of Technology (DUT), took the audience on a breathtaking journey on the topic of oral knowledge. Her presentation showed examples, both European and African oral knowledge and had a clear message for language practitioners: What can Africans learn from the Western mind? Her answer: "Africans can learn how easy it is to loose one’s oral knowledge base. Africans can look at the West and see what the consequences are when a culture loses its oral-based knowledge. Language practitioners have it in their power to consider this possible loss and do something about it."

Lastly, Ms Lolie Makhubu, Head of the Department of Language and Translation at DUT, spoke about enticement in interpreting to use loan words to impress either the audience or peers or clients. Her argument boils down to the interpreter’s attitude towards African culture and language. If Western culture is regarded as higher than African culture, interpreters will be tempted to boast their knowledge of Western culture by means of their choice of words. However, if interpreters are “Proudly South African”, as she put it, they have not need for showing off by using loan words.


 

Dr Kobus Marais (Senior Lecturer in Translation Studies at the UFS) during the seminar.
Photo (supplied)

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