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Prof Mogomme Masoga appointed as Dean: Faculty of the Humanities at the UFS

13 December 2022 | Story Lacea Loader | Photo Supplied

The Council of the University of the Free State (UFS) approved the appointment of Prof Mogomme Masoga as Dean of the Faculty of the Humanities for a five-year term during its quarterly meeting on 25 November 2022.

He is currently the Dean of the Faculty of Humanities and Social Sciences at the University of Zululand.

“Prof Masoga has extensive and an impressive national and international research standing, established networks and partnerships, and substantive management experience. He is a visionary leader and a renowned scholar and will be able to lead and manage the faculty at academic, research, engaged scholarship, and community-service level,” says Prof Francis Petersen, UFS Rector and Vice-Chancellor.

Prof Masoga holds a PhD in Philosophy from the University of the Free State. He began his academic career with a Bachelor of Arts from the University of KwaZulu-Natal, where he proceeded to complete two honours and a master’s degree. He received a second Master of Arts in Musicology from the University of South Africa.

Prof Masoga has an excellent record of research publication within the broad niche area of Oral History, Africanism, and Indigenous Knowledge System Studies. He has developed a well-grounded sense of autonomy and involvement, as he has been able to establish a number of research projects and has produced single and co-authored articles. He was able to synergise and sustain his research niche on Africanism and Indigenous Knowledge Studies, which has informed his research over the years.

He has maintained a coherent research trajectory as a recognised NRF-rated scholar in Indigenous Knowledge System Studies. Prof Masoga’s participation in international collaborative projects has had a positive impact on his scholarly growth, as well as on other colleagues and departments in his faculty at the University of Zululand.

“Prof Masoga will be able to sustain his existing networks and build new ones that will support research and postgraduate studies at the UFS. This will be particularly valuable in support of the university’s Vision 130, which expresses the institution’s strategic intent to position itself in the period leading up to 2034 when the university will be 130 years old. Vision 130 furthermore exemplifies our commitment to be acknowledged by our peers and society as a top-tier university in South Africa, ranked among the best in the world,” says Prof Petersen.

Prof Masoga will assume duty on 1 March 2023.

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

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