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14 December 2022 | Story Lacea Loader | Photo Supplied
Prof Serges Kamga
Prof Serges Kamga, newly appointed Dean: Faculty of Law.

The Council of the University of the Free State (UFS) approved the appointment of Prof Serges Kamga as Dean of the Faculty of Law for a five-year term during its quarterly meeting on 25 November 2022. 

Prof Kamga is a full Professor of Law currently working at the Thabo Mbeki African School of Public and International Affairs (TMS) at the University of South Africa (UNISA).

“Prof Kamga’s excellent research reputation nationally and internationally, his extensive networks and partnerships will contribute to further raising the profile of the Faculty of Law nationally, on the continent and globally.  As an established NRF-rated researcher, he will also be able to enhance the research output of the faculty,” says Prof Francis Petersen, UFS Rector and Vice-Chancellor. 

“Prof Kamga will lead and manage the Faculty of Law in support of the UFS’ Vision 130 and the ultimate intent for the coming years to be a research-led, student-centred, and regionally engaged university that contributes to development and social justice through the production of globally competitive graduates and knowledge, and that impactfully supports societal development,” says Prof Petersen.  

Prof Kamga is co-director of the Cross-Cultural Human Rights Centre at the Free University of Amsterdam in the Netherlands. At times, he has acted as head of the Thabo Mbeki African Leadership Institute currently Thabo Mbeki School at UNISA and has had engagements at the United States Agency for International Development (USAID), the Young African Leaders Initiative, and as managing consultant at African Legal Sources at the University of Pretoria. In 2021, he received the prestigious Ali Mazrui Award for Scholarship and Research Excellence from the University of Texas at Austin in the USA.

He holds an LLD degree in Human Rights Law from the Centre for Human Rights, University of Pretoria. Prof Kamga has also worked as a researcher at the South African Institute for Advanced Constitutional, Public, Human Rights and International Law (SAIFAC). As a researcher, he has published in accredited journals and presented papers at various national and international conferences. 

“Prof Kamga’s experience in these positions, as well as his extensive knowledge and understanding of the South African and global law fraternity, places him in good standing to lead the faculty to become a formidable and impactful force nationally, on the continent, and abroad. He will also lead the faculty to exploit opportunities and deal with the challenges that the rapidly changing higher-education environment has to deal with,” says Prof Petersen.

Prof Kamga will assume duty on 1 February 2023.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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