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02 February 2022 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Chané Enslin, master’s student in the UFS Centre for Environmental Management (CEM); Stephanie Graumnitz, Institute of Hydrobiology at the Technical University Dresden (TUD); Dr Dirk Jungmann, Head of Ecotoxicology and Biomonitoring in the Institute of Hydrobiology at TUD; Sihle Mlonyeni, master’s student in the Faculty of Applied Science at the Cape Peninsula Technical University; Dr Marinda Avenant, Senior Lecturer in the CEM at the UFS; Akani Baloyi, master’s student in the UFS Disaster Management Training and Education Centre for Africa; and Sphindile Dlamini, master’s student in the Department of Zoology and Entomology on the UFS Qwaqwa Campus.


The Centre for Environmental Management (CEM) at the University of the Free State (UFS), in collaboration with Dr Dirk Jungmann from the Technical University Dresden, recently presented a virtual summer school on Blackboard, titled: Monitoring of surface water quality: General framework, tools and implementing disaster management aspects in urban areas. 

The international group of 30 persons who attended the summer school mostly comprised postgraduate students and employees from, among others, the UFS and other tertiary institutions such as the Technical University Dresden (TUD), the Cape Peninsula University of Technology (CPUT), UNISA, the University of the Western Cape, Stellenbosch University, the University of Lesotho, and the University of Zimbabwe. Members of the Council for Scientific and Industrial Research also attended the summer school.

Experts present

Dr Marinda Avenant, Senior Lecturer in the CEM, believes the summer school provides students with a wonderful opportunity to be exposed to a topic, such as aquatic biomonitoring, over and above their normal postgraduate studies. “The presenters are all experts in their field and come from a range of disciplines (from hydrology and chemistry to the social aspects of water), as well as from different countries and perspectives,” she adds. 

Some interesting topics covered during the summer school included a panel discussion on water management challenges in Southern Africa. Head of CEM, Prof Paul Oberholser, participated in this live discourse. In 2021, he won the NSTF-Water Research Commission (WRC) Award for his contribution to water resource management in SA over the past five years.

Also contributing a perspective on surface water quality was affiliated professor in CEM, Prof Anthony Turton, who delivered the keynote address on Managing surface water quality as an element of disaster management in urban areas.

Dr Alice Ncube from the UFS Disaster Management Training and Education Centre (DiMTEC) presented on women and disasters (including a case study on a stokvel in Botshabelo), and Dr Inga Jacobs-Mata from the International Water Management Institute (IWMI) provided a social perspective on the water resources sector. 

Students excel 

Five master’s students representing the UFS, the Technical University Dresden (TUD), as well as the Cape Peninsula University of Technology (CPUT), assisted with the organisation of the summer school. The Volkswagen Foundation in Germany, which funded a first summer school in 2019, provided funding that was used to appoint the five students.

According to Dr Avenant, they made provision for the appointment of these students in their project proposal to the Volkswagen Foundation. “The students played a key role in the planning of the virtual summer school; they specially came up with ideas to make the virtual sessions more interesting,” she says.

Among others, they managed the technical aspects of the sessions, introduced the speakers, arranged social activities for the virtual platform, and they produced podcasts. The podcasts of the speakers were distributed to the participants over the extent of two months, in order to learn more about the presenters. 

“We were really impressed with the work of the students, who are all from the natural sciences,” says Dr Avenant.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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