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11 March 2022 | Story NONSINDISO QWABE | Photo Supplied
Dr Ralph Clarke
Dr Ralph Clark, Director of the Afromontane Research Unit.

The African Mountain Research Foundation (AMRF), in association with the Afromontane Research Unit (ARU) of the University of the Free State (UFS), and the Global Mountain Safeguard Research Programme (GLOMOS), is hosting the first-ever Southern African Mountain Conference (SAMC2022). The theme of the conference is Southern African Mountains – their value and vulnerabilities.

The conference will bring relevant people together into one space for networking and information sharing, leading to more robust regional and international collaborations and comparative mountain studies with an increase in research activities, student capacity, researcher capacity and academic outputs that feed into policy and action. 

The conference will take place from 14 to 17 March 2022 in the majestic Maloti-Drakensberg Mountains in South Africa and Lesotho. 

According to the SAMC2022 website, this is a truly Southern African regional mountain conference, targeting the African region south of the Congo rainforest (DRC) and Lake Rukwa (Tanzania), but including Madagascar, the Comoros and the Mascarenes (i.e., Angola, the Comoros, the Democratic Republic of the Congo [southern mountains], Eswatini, Lesotho, Madagascar, Malawi, Mauritius, Mozambique, Namibia, La Réunion, South Africa, southern Tanzania, Zambia, and Zimbabwe).

Dr Ralph Clark, ARU Director, said the conference would be a high-level international event with UNESCO patronage and very valuable sponsors.

“The programme will have six parallel tracks (one being dedicated to postgraduate students), with about 200 papers being delivered. In addition, we have some very high-profile special sessions, such as an MRI special session on long-term monitoring activities and associated data availability for climate change-related applications across Africa’s mountains, as well as a UNESCO special session on regional collaboration. We also have Prof Julian Bayliss, described as the man who discovered an unseen world, as the guest speaker at the closing event.”

The conference will bring together relevant people in one space for networking and information sharing, leading to more robust regional and international collaborations and comparative mountain studies, with an increase in research activities, student capacity, researcher capacity, and academic outputs that feed into policy and action.

The GLOMOS team, one of the long-term partners of the ARU, spent the week of 8 to 11 March 2022 on the Qwaqwa Campus to strengthen collaboration and pave the way for new research opportunities in Phuthaditjhaba and the Maloti-Drakensberg.
GLOMOS represents an interface between the United Nations University Institute for Environment and Human Security (UNU-EHS) and Eurac Research. Postdoctoral fellow, Dr Stefano Terzi, said: “It’s very interesting for us to look at the Maloti-Drakensberg area because of its diversity. We are in the process of really exciting collaborations.”
Their projects include an understanding of the root causes of land degradation and improving decision-making processes for current water management within the context of water scarcity in the Maloti-Drakensberg.
• For more information on the speakers and the programme, click here 


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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