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28 March 2022 | Story Leonie Bolleurs | Photo Sonia Small (Kaleidoscope Studios)
Prof Francis Petersen and Dr Khotso Mokhele
During the signing ceremony, delegates had the opportunity to visit the MAGIC laboratory, which is housed in the Geology Building on the UFS Bloemfontein Campus. From the left, are Prof Francis Petersen and Dr Khotso Mokhele.

Did you know that one can photograph a plant so clearly from a distance that it is likely to detect the health of its leaves? Or can you contemplate the possibility of taking a photograph of three similar-looking rocks, being able to distinguish them from each other due to spectral properties associated with their internal mineral content?

This and other drone-based geological imaging are made possible by the Merensky group for Aerial Geological Image Classification (MAGIC) at the University of the Free State (UFS).

Recently (24 March 2022), the President of the Hans Merensky Foundation (HMF), Dr Khotso Mokhele, signed a R11 million five-year research grant agreement with the UFS. Merensky research projects are currently limited to three South African universities – Stellenbosch University (for forestry research), the University of Pretoria (for avocados), and now the UFS.

Demonstration and application

Dr Mokhele, who is also the former Chancellor of the UFS, states: “When I walked into the MAGIC Lab, I knew that something special was going to happen here. What we are launching today will become a world-class and world-leading facility.”

According to him, Dr Hans Merensky, whose legacy is facilitated by the foundation, was one of the most influential geologists in South Africa. He discovered, among others, deposits of gold, platinum, diamonds, phosphates, and vermiculite. After several decades of operating in the geological sciences and with his knowledge of soil health, Merensky became a conservationist of note and played a key role in the establishment of the country’s agricultural practices.

“The main objective of the Hans Merensky Foundation is to promote and assist in the development of the resources of South Africa and neighbouring territories – particularly such natural resources as soil, water, flora, and fauna – and to promote the health and welfare of the inhabitants; more specifically, through research, experimentation, and demonstration and through the correlation and application of scientific knowledge.” 

“You have to take the knowledge and translate it into demonstration of what that knowledge can do, and then apply it,” says Dr Mokhele.

The grant is also evidence of Dr Merensky’s generosity. He is well quoted saying: “This country has given to me so much, that I am only too happy to be allowed to help it to develop in some way, and I am grateful to be able to give back to it a fraction of what it has given to me.” 

Next generation of scientists

The Rector and Vice-Chancellor of the UFS, Prof Francis Petersen, said at the signing ceremony that this is an exciting project. “For us as a university, research and the development of the next generation of scientists are critical. This is part of our mandate. This project is one of those catalysts for the development of what the mandate is all about – research output, capacity building, and impact through our students and our research in a broader society.”

He thanked Dr Mokhele for facilitating the project and introducing the UFS to the Hans Merensky Foundation, having the confidence that the university has the capacity to deliver.  

“For Dr Mokhele, it is all about the science. To a certain extent, his driving force was to use science to make a difference in the lives of people,” says Prof Petersen. 

He continues: “The institution is highly committed to this project and will make sure that it receives the maximum support to make it a success.”

The grant has been allocated to MAGIC and funds will be used to support research programmes. “This includes student bursaries, staff salaries, capital expenditure acquisitions such as high-performance computers, as well as the drones that the project makes use of,” states Dr Martin Clark, Lecturer in the Department of Geology.

According to him, the group aims to develop drone-based geological imaging in South Africa, with specific attention to mineral and groundwater exploration endeavours.

Dr Martin Clark
(Dr Martin Clark, principal investigator of MAGIC, says what makes him excited about this project is how the research impacts
society. Photo: Sonia Small

Impacting society 
 
“What makes me excited about this project is how the research impacts society.  This includes developing geological imaging capacity in South African geologists with a 4IR skillset, ensuring that they remain competitive in a global market,” says Dr Clark.

He is also of the opinion that many industries will be able to see for themselves how this technology can improve their businesses. “Drone-based geological imaging can be quicker, cheaper, and safer for collecting much of the initial information that informs more expensive exploration processes, such as drilling. Additionally, it is non-invasive, and has little to no impact on the environment during data collection. Drones can also, in terms of safety, collect data from unstable rock walls – historically, geologists would have to take those measurements themselves, with rock falls resulting in a significant number of deaths every year.”

Recent research

Dr Clark says drone-based imaging has supported research initiatives in the Vredefort Dome. “Using drone-collected high-resolution images of meteorite impact melt rocks, along with field observations of how much and where foreign rock components were contained within (clasts), we could make a case for turbulent flow in the migration of impact melt material within the deep crust.”
 
He adds that three papers are currently underway, each predicated on drone imagery that enables new insights into geological processes or the ability to digitally translate geological information inside and outside the classroom.

The growing research group, with Dr Clark as the principal investigator, consists of one PhD student, two master’s students, and two honours students, with several postdoctoral research fellows to follow soon. 

The difference

Although several universities in the country have started using drones, the UFS has significant support to grow drone applications. With assets such as the high-performance computing cluster, very large drone-borne datasets can be resolved in record time.  

“The UFS also has a wealth of world-class researchers focused on topics such as farming and environmental management, who will be able to benefit from the drone infrastructure being established on campus. We are aiming to be the go-to geological drone imaging group in South Africa,” he says. 




About mineral and groundwater exploration


Dr Martin Clark explains that drones can carry several types of cameras, from regular photographic cameras that capture photos as we know it, to thermal cameras showing differences in hot and cold bodies, to spectral cameras capturing beyond what our eyes can see into other portions of the electromagnetic spectrum.  The MAGIC group mainly uses regular and spectral cameras for their applications. 

He says with mineral exploration, a high-resolution understanding of the geometry of rock bodies enables us to better identify where more costly mineral exploration techniques (e.g., drilling) should go.  This process allows for a better understanding of how geological areas have developed from a structural perspective – in essence, from where and how rocks have been displaced and deformed, and by association, the mineral deposits contained within.

“In terms of groundwater exploration, regular cameras are used to understand where rocks are fractured, where specific groundwater-influencing lithological bodies are located, and how they are orientated.” 

Dr Clark continues: “With spectral cameras, we can perceive the level of access that surface plants have to water resources. It is also possible to spot the distribution of plant types associated with, or strongly dependent on, available near-surface groundwater resources.  By using spectral data, which was historically collected from satellites, we can understand how areas of land have been affected by growing, shrinking, or shifting underground bodies of water.”




News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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