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28 March 2022 | Story Leonie Bolleurs | Photo Sonia Small (Kaleidoscope Studios)
Prof Francis Petersen and Dr Khotso Mokhele
During the signing ceremony, delegates had the opportunity to visit the MAGIC laboratory, which is housed in the Geology Building on the UFS Bloemfontein Campus. From the left, are Prof Francis Petersen and Dr Khotso Mokhele.

Did you know that one can photograph a plant so clearly from a distance that it is likely to detect the health of its leaves? Or can you contemplate the possibility of taking a photograph of three similar-looking rocks, being able to distinguish them from each other due to spectral properties associated with their internal mineral content?

This and other drone-based geological imaging are made possible by the Merensky group for Aerial Geological Image Classification (MAGIC) at the University of the Free State (UFS).

Recently (24 March 2022), the President of the Hans Merensky Foundation (HMF), Dr Khotso Mokhele, signed a R11 million five-year research grant agreement with the UFS. Merensky research projects are currently limited to three South African universities – Stellenbosch University (for forestry research), the University of Pretoria (for avocados), and now the UFS.

Demonstration and application

Dr Mokhele, who is also the former Chancellor of the UFS, states: “When I walked into the MAGIC Lab, I knew that something special was going to happen here. What we are launching today will become a world-class and world-leading facility.”

According to him, Dr Hans Merensky, whose legacy is facilitated by the foundation, was one of the most influential geologists in South Africa. He discovered, among others, deposits of gold, platinum, diamonds, phosphates, and vermiculite. After several decades of operating in the geological sciences and with his knowledge of soil health, Merensky became a conservationist of note and played a key role in the establishment of the country’s agricultural practices.

“The main objective of the Hans Merensky Foundation is to promote and assist in the development of the resources of South Africa and neighbouring territories – particularly such natural resources as soil, water, flora, and fauna – and to promote the health and welfare of the inhabitants; more specifically, through research, experimentation, and demonstration and through the correlation and application of scientific knowledge.” 

“You have to take the knowledge and translate it into demonstration of what that knowledge can do, and then apply it,” says Dr Mokhele.

The grant is also evidence of Dr Merensky’s generosity. He is well quoted saying: “This country has given to me so much, that I am only too happy to be allowed to help it to develop in some way, and I am grateful to be able to give back to it a fraction of what it has given to me.” 

Next generation of scientists

The Rector and Vice-Chancellor of the UFS, Prof Francis Petersen, said at the signing ceremony that this is an exciting project. “For us as a university, research and the development of the next generation of scientists are critical. This is part of our mandate. This project is one of those catalysts for the development of what the mandate is all about – research output, capacity building, and impact through our students and our research in a broader society.”

He thanked Dr Mokhele for facilitating the project and introducing the UFS to the Hans Merensky Foundation, having the confidence that the university has the capacity to deliver.  

“For Dr Mokhele, it is all about the science. To a certain extent, his driving force was to use science to make a difference in the lives of people,” says Prof Petersen. 

He continues: “The institution is highly committed to this project and will make sure that it receives the maximum support to make it a success.”

The grant has been allocated to MAGIC and funds will be used to support research programmes. “This includes student bursaries, staff salaries, capital expenditure acquisitions such as high-performance computers, as well as the drones that the project makes use of,” states Dr Martin Clark, Lecturer in the Department of Geology.

According to him, the group aims to develop drone-based geological imaging in South Africa, with specific attention to mineral and groundwater exploration endeavours.

Dr Martin Clark
(Dr Martin Clark, principal investigator of MAGIC, says what makes him excited about this project is how the research impacts
society. Photo: Sonia Small

Impacting society 
 
“What makes me excited about this project is how the research impacts society.  This includes developing geological imaging capacity in South African geologists with a 4IR skillset, ensuring that they remain competitive in a global market,” says Dr Clark.

He is also of the opinion that many industries will be able to see for themselves how this technology can improve their businesses. “Drone-based geological imaging can be quicker, cheaper, and safer for collecting much of the initial information that informs more expensive exploration processes, such as drilling. Additionally, it is non-invasive, and has little to no impact on the environment during data collection. Drones can also, in terms of safety, collect data from unstable rock walls – historically, geologists would have to take those measurements themselves, with rock falls resulting in a significant number of deaths every year.”

Recent research

Dr Clark says drone-based imaging has supported research initiatives in the Vredefort Dome. “Using drone-collected high-resolution images of meteorite impact melt rocks, along with field observations of how much and where foreign rock components were contained within (clasts), we could make a case for turbulent flow in the migration of impact melt material within the deep crust.”
 
He adds that three papers are currently underway, each predicated on drone imagery that enables new insights into geological processes or the ability to digitally translate geological information inside and outside the classroom.

The growing research group, with Dr Clark as the principal investigator, consists of one PhD student, two master’s students, and two honours students, with several postdoctoral research fellows to follow soon. 

The difference

Although several universities in the country have started using drones, the UFS has significant support to grow drone applications. With assets such as the high-performance computing cluster, very large drone-borne datasets can be resolved in record time.  

“The UFS also has a wealth of world-class researchers focused on topics such as farming and environmental management, who will be able to benefit from the drone infrastructure being established on campus. We are aiming to be the go-to geological drone imaging group in South Africa,” he says. 




About mineral and groundwater exploration


Dr Martin Clark explains that drones can carry several types of cameras, from regular photographic cameras that capture photos as we know it, to thermal cameras showing differences in hot and cold bodies, to spectral cameras capturing beyond what our eyes can see into other portions of the electromagnetic spectrum.  The MAGIC group mainly uses regular and spectral cameras for their applications. 

He says with mineral exploration, a high-resolution understanding of the geometry of rock bodies enables us to better identify where more costly mineral exploration techniques (e.g., drilling) should go.  This process allows for a better understanding of how geological areas have developed from a structural perspective – in essence, from where and how rocks have been displaced and deformed, and by association, the mineral deposits contained within.

“In terms of groundwater exploration, regular cameras are used to understand where rocks are fractured, where specific groundwater-influencing lithological bodies are located, and how they are orientated.” 

Dr Clark continues: “With spectral cameras, we can perceive the level of access that surface plants have to water resources. It is also possible to spot the distribution of plant types associated with, or strongly dependent on, available near-surface groundwater resources.  By using spectral data, which was historically collected from satellites, we can understand how areas of land have been affected by growing, shrinking, or shifting underground bodies of water.”




News Archive

Cardiology Unit involved in evaluation of drug for rare genetic disease
2013-01-04

Front from the left, are: Marinda Karsten (study coordinator and registered nurse),
Laumarie de Wet (clinical technologist), Charmaine Krahenbuhl (study coordinator and radiographer),
Lorinda de Meyer (administrator), Andonia Page (study coordinator and enrolled nurse);
back Dr Gideon Visagie (sub investigator), Dr Derick Aucamp (sub investigagtor),
Prof. Hennie Theron, (principal investigator) and Dr Wilhelm Herbst (sub investigator).
Photo: Supplied
09 January 2013


The Cardiology Research Unit at the University of the Free State (UFS) contributed largely to the evaluation of the drug Juxtapid (lomitapide), which was developed by the Aegerion pharmaceutical company and approved by the FDA (Federal Drug Administration). Together with countries such as die USA, Canada and Italy, the UFS’ Unit recruited and evaluated the most patients (5 of 29) for the study since 2008.  

The drug was evaluated in persons with so-called familial homozygous hypercholesterolemia (HoFH).  

Following its approval by the FDA, Juxtapid is now a new treatment option for patients suffering from HoFH. The drug operates in a unique way which brings about dramatic improvements in cholesterol counts.  

According to Prof. Hennie Theron, Associate Professor in the Department of Cardiology at the UFS and Head of the Cardiology Contract Research Unit, HoFH is a serious, rare genetic disease which affects the function of the receptor responsible for the removal of low-density lipoprotein cholesterol (LDL-C) (“bad” cholesterol) from the body. Damage to the LDL receptor function leads to extremely high levels of blood cholesterol. HoFH patients often develop premature and progressive atherosclerosis, which is a narrowing or blockage of the arteries.  

“HoFH is a genetically transmitted disease and the most severe form of hypercholesterolemia. Patients often need a coronary artery bypass or/and aortic valve replacement before the age of 20. Mortality is extremely high and death often occurs before the third decade of life. Existing conventional cholesterol-lowering medication is unsuccessful in achieving normal target cholesterol values in this group of patients.  

“The only modality for treatment is plasmapheresis (similar to dialysis in patients with renal failure). Even with this type of therapy the results are relatively unsatisfactory because it is very expensive and the plasmapheresis has to be performed on a regular basis.  

“The drug Juxtapid, as currently evaluated, has led to a dramatic reduction in cholesterol values and normal values were achieved in several people. No existing drug is nearly as effective.  

“The drug represents a breakthrough in the treatment of familial homozygous hypercholesterolemia. The fact that it has been approved by the FDA, gives further impetus to the findings,” says Prof. Theron.  

In future further evaluation will be performed in other forms of hypocholesterolemia.  

According to Prof. Theron, the findings of the study, as well as the recent successful FDA evaluation, once again confirms the fact that the UFS’ Cardiology Contract Research Unit is doing outstanding work.  

Since its inception in 1992, the Unit has already been involved in more than 60 multi-centre, international phase 2 and 3 drug studies. Several of these studies, including the abovementioned study, really affected the way in which cardiology functions.  

The UFS’ Cardiology Contract Research Unit is being recognised nationally and internationally for its high quality of work and is constantly approached for their involvement in new studies.  

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