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28 March 2022 | Story Leonie Bolleurs | Photo Sonia Small (Kaleidoscope Studios)
Prof Francis Petersen and Dr Khotso Mokhele
During the signing ceremony, delegates had the opportunity to visit the MAGIC laboratory, which is housed in the Geology Building on the UFS Bloemfontein Campus. From the left, are Prof Francis Petersen and Dr Khotso Mokhele.

Did you know that one can photograph a plant so clearly from a distance that it is likely to detect the health of its leaves? Or can you contemplate the possibility of taking a photograph of three similar-looking rocks, being able to distinguish them from each other due to spectral properties associated with their internal mineral content?

This and other drone-based geological imaging are made possible by the Merensky group for Aerial Geological Image Classification (MAGIC) at the University of the Free State (UFS).

Recently (24 March 2022), the President of the Hans Merensky Foundation (HMF), Dr Khotso Mokhele, signed a R11 million five-year research grant agreement with the UFS. Merensky research projects are currently limited to three South African universities – Stellenbosch University (for forestry research), the University of Pretoria (for avocados), and now the UFS.

Demonstration and application

Dr Mokhele, who is also the former Chancellor of the UFS, states: “When I walked into the MAGIC Lab, I knew that something special was going to happen here. What we are launching today will become a world-class and world-leading facility.”

According to him, Dr Hans Merensky, whose legacy is facilitated by the foundation, was one of the most influential geologists in South Africa. He discovered, among others, deposits of gold, platinum, diamonds, phosphates, and vermiculite. After several decades of operating in the geological sciences and with his knowledge of soil health, Merensky became a conservationist of note and played a key role in the establishment of the country’s agricultural practices.

“The main objective of the Hans Merensky Foundation is to promote and assist in the development of the resources of South Africa and neighbouring territories – particularly such natural resources as soil, water, flora, and fauna – and to promote the health and welfare of the inhabitants; more specifically, through research, experimentation, and demonstration and through the correlation and application of scientific knowledge.” 

“You have to take the knowledge and translate it into demonstration of what that knowledge can do, and then apply it,” says Dr Mokhele.

The grant is also evidence of Dr Merensky’s generosity. He is well quoted saying: “This country has given to me so much, that I am only too happy to be allowed to help it to develop in some way, and I am grateful to be able to give back to it a fraction of what it has given to me.” 

Next generation of scientists

The Rector and Vice-Chancellor of the UFS, Prof Francis Petersen, said at the signing ceremony that this is an exciting project. “For us as a university, research and the development of the next generation of scientists are critical. This is part of our mandate. This project is one of those catalysts for the development of what the mandate is all about – research output, capacity building, and impact through our students and our research in a broader society.”

He thanked Dr Mokhele for facilitating the project and introducing the UFS to the Hans Merensky Foundation, having the confidence that the university has the capacity to deliver.  

“For Dr Mokhele, it is all about the science. To a certain extent, his driving force was to use science to make a difference in the lives of people,” says Prof Petersen. 

He continues: “The institution is highly committed to this project and will make sure that it receives the maximum support to make it a success.”

The grant has been allocated to MAGIC and funds will be used to support research programmes. “This includes student bursaries, staff salaries, capital expenditure acquisitions such as high-performance computers, as well as the drones that the project makes use of,” states Dr Martin Clark, Lecturer in the Department of Geology.

According to him, the group aims to develop drone-based geological imaging in South Africa, with specific attention to mineral and groundwater exploration endeavours.

Dr Martin Clark
(Dr Martin Clark, principal investigator of MAGIC, says what makes him excited about this project is how the research impacts
society. Photo: Sonia Small

Impacting society 
 
“What makes me excited about this project is how the research impacts society.  This includes developing geological imaging capacity in South African geologists with a 4IR skillset, ensuring that they remain competitive in a global market,” says Dr Clark.

He is also of the opinion that many industries will be able to see for themselves how this technology can improve their businesses. “Drone-based geological imaging can be quicker, cheaper, and safer for collecting much of the initial information that informs more expensive exploration processes, such as drilling. Additionally, it is non-invasive, and has little to no impact on the environment during data collection. Drones can also, in terms of safety, collect data from unstable rock walls – historically, geologists would have to take those measurements themselves, with rock falls resulting in a significant number of deaths every year.”

Recent research

Dr Clark says drone-based imaging has supported research initiatives in the Vredefort Dome. “Using drone-collected high-resolution images of meteorite impact melt rocks, along with field observations of how much and where foreign rock components were contained within (clasts), we could make a case for turbulent flow in the migration of impact melt material within the deep crust.”
 
He adds that three papers are currently underway, each predicated on drone imagery that enables new insights into geological processes or the ability to digitally translate geological information inside and outside the classroom.

The growing research group, with Dr Clark as the principal investigator, consists of one PhD student, two master’s students, and two honours students, with several postdoctoral research fellows to follow soon. 

The difference

Although several universities in the country have started using drones, the UFS has significant support to grow drone applications. With assets such as the high-performance computing cluster, very large drone-borne datasets can be resolved in record time.  

“The UFS also has a wealth of world-class researchers focused on topics such as farming and environmental management, who will be able to benefit from the drone infrastructure being established on campus. We are aiming to be the go-to geological drone imaging group in South Africa,” he says. 




About mineral and groundwater exploration


Dr Martin Clark explains that drones can carry several types of cameras, from regular photographic cameras that capture photos as we know it, to thermal cameras showing differences in hot and cold bodies, to spectral cameras capturing beyond what our eyes can see into other portions of the electromagnetic spectrum.  The MAGIC group mainly uses regular and spectral cameras for their applications. 

He says with mineral exploration, a high-resolution understanding of the geometry of rock bodies enables us to better identify where more costly mineral exploration techniques (e.g., drilling) should go.  This process allows for a better understanding of how geological areas have developed from a structural perspective – in essence, from where and how rocks have been displaced and deformed, and by association, the mineral deposits contained within.

“In terms of groundwater exploration, regular cameras are used to understand where rocks are fractured, where specific groundwater-influencing lithological bodies are located, and how they are orientated.” 

Dr Clark continues: “With spectral cameras, we can perceive the level of access that surface plants have to water resources. It is also possible to spot the distribution of plant types associated with, or strongly dependent on, available near-surface groundwater resources.  By using spectral data, which was historically collected from satellites, we can understand how areas of land have been affected by growing, shrinking, or shifting underground bodies of water.”




News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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