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03 November 2022 | Story Leonie Bolleurs | Photo Supplied
Dr Liezel Rudolph
Dr Liezel Rudolph, a lecturer in the Department of Geography, recently returned from an expedition to Gough Island in the South Atlantic Ocean, where she was involved in research that aims to better understand the landscape evolution of some subantarctic islands and their response to long-term climate change.

A study of subantarctic islands tells us that, in general, the Southern Hemisphere is experiencing a rise in temperature, with an increase in rainfall in some locations, and other areas becoming drier. The annual temperature and rainfall average remain the same in some places, but there is a change in seasonality and synoptic weather events.

This is according to Dr Liezel Rudolph, a lecturer in the Department of Geography at the University of the Free State (UFS). She recently returned from an expedition to Gough Island in the South Atlantic Ocean, supported by the South African National Department of Forestry, Fisheries and the Environment, the National Research Foundation, and the Royal Society for the Protection of Birds.

This teacher of modules on Process Geomorphology and fieldwork techniques at the UFS, says the objective of her work on the island was to do a geomorphological survey of the island and explore the suitability of geochronological dating techniques on the island’s substrate. 

She explains that with geochronological methods one can determine the age of rock material as well as the rate of landscape change on the island. “In other words, dating when the volcano was formed and determining how long it takes for weathering to break down the rock material, and erosional processes to remove soil material.”
 
The research she is involved in, forms part of a SANAP-NRF-funded project, Sub-Antarctic Landscape Climate Interactions, which aims to better understand the landscape evolution of some subantarctic Islands and their response to long-term climate change. 

Studying the past to understand the present

According to her, studying landscape change enables one to better understand climate change over a long period of time. 

She states that the more regions are investigated, the clearer the picture of climate change will become. “The Earth is a large, complex system. By studying climate change in one location, one cannot simply assume that the same type and rate of change is occurring everywhere else. It would be like imaging a 1 000-piece puzzle by building with 10 pieces. The Southern Hemisphere is predominantly ocean, which makes it difficult to pin down land-atmosphere interactions – but the subantarctic islands give us the opportunity to create data points for the Southern Hemisphere, which would otherwise be a very large missing piece of the puzzle,” explains Dr Rudolph.

She says the interaction between ocean, atmosphere, and land remains complex and it is important to study the entire picture in order to fully understand how this is happening. Especially since the climate is changing at a drastic rate.

Dr Rudolph, whose research at the UFS is focused on constraining the last glaciation of subantarctic Marion Island though various proxies and dating techniques, says the subantarctic islands are very sensitive to changes in climate. 

A clearer picture of climate change

She was part of previous expeditions to the island. Although all these expeditions had different goals, according to her, they all aimed to answer the same questions, which are how the island’s landscape has developed throughout history and what the climatic drivers were during its evolution. 

“The landscape responds to changes in temperature and precipitation. Under colder, wetter conditions – when the island’s surface is subject to a freeze-thaw process – a range of peri-glacial landforms will develop. These landforms will still be evident in the landscape years later under a different climate, for example, warmer or drier conditions. We can study these landforms in real-time and establish whether they are actively forming or are relict features that formed under different climatic environments,” remarks Dr Rudolph.

The research, which is taking place in collaboration with the British Antarctic Survey, is co-led by Prof Werner Nel from the University of Fort Hare, and Prof David Hedding from the University of South Africa. 

• Dr Rudolph is grateful to the Government of Tristan da Cunha, which is responsible for managing the conservation of Gough Island, for permitting them to do scientific work on the island. 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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