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03 November 2022 | Story Leonie Bolleurs | Photo Supplied
Dr Liezel Rudolph
Dr Liezel Rudolph, a lecturer in the Department of Geography, recently returned from an expedition to Gough Island in the South Atlantic Ocean, where she was involved in research that aims to better understand the landscape evolution of some subantarctic islands and their response to long-term climate change.

A study of subantarctic islands tells us that, in general, the Southern Hemisphere is experiencing a rise in temperature, with an increase in rainfall in some locations, and other areas becoming drier. The annual temperature and rainfall average remain the same in some places, but there is a change in seasonality and synoptic weather events.

This is according to Dr Liezel Rudolph, a lecturer in the Department of Geography at the University of the Free State (UFS). She recently returned from an expedition to Gough Island in the South Atlantic Ocean, supported by the South African National Department of Forestry, Fisheries and the Environment, the National Research Foundation, and the Royal Society for the Protection of Birds.

This teacher of modules on Process Geomorphology and fieldwork techniques at the UFS, says the objective of her work on the island was to do a geomorphological survey of the island and explore the suitability of geochronological dating techniques on the island’s substrate. 

She explains that with geochronological methods one can determine the age of rock material as well as the rate of landscape change on the island. “In other words, dating when the volcano was formed and determining how long it takes for weathering to break down the rock material, and erosional processes to remove soil material.”
 
The research she is involved in, forms part of a SANAP-NRF-funded project, Sub-Antarctic Landscape Climate Interactions, which aims to better understand the landscape evolution of some subantarctic Islands and their response to long-term climate change. 

Studying the past to understand the present

According to her, studying landscape change enables one to better understand climate change over a long period of time. 

She states that the more regions are investigated, the clearer the picture of climate change will become. “The Earth is a large, complex system. By studying climate change in one location, one cannot simply assume that the same type and rate of change is occurring everywhere else. It would be like imaging a 1 000-piece puzzle by building with 10 pieces. The Southern Hemisphere is predominantly ocean, which makes it difficult to pin down land-atmosphere interactions – but the subantarctic islands give us the opportunity to create data points for the Southern Hemisphere, which would otherwise be a very large missing piece of the puzzle,” explains Dr Rudolph.

She says the interaction between ocean, atmosphere, and land remains complex and it is important to study the entire picture in order to fully understand how this is happening. Especially since the climate is changing at a drastic rate.

Dr Rudolph, whose research at the UFS is focused on constraining the last glaciation of subantarctic Marion Island though various proxies and dating techniques, says the subantarctic islands are very sensitive to changes in climate. 

A clearer picture of climate change

She was part of previous expeditions to the island. Although all these expeditions had different goals, according to her, they all aimed to answer the same questions, which are how the island’s landscape has developed throughout history and what the climatic drivers were during its evolution. 

“The landscape responds to changes in temperature and precipitation. Under colder, wetter conditions – when the island’s surface is subject to a freeze-thaw process – a range of peri-glacial landforms will develop. These landforms will still be evident in the landscape years later under a different climate, for example, warmer or drier conditions. We can study these landforms in real-time and establish whether they are actively forming or are relict features that formed under different climatic environments,” remarks Dr Rudolph.

The research, which is taking place in collaboration with the British Antarctic Survey, is co-led by Prof Werner Nel from the University of Fort Hare, and Prof David Hedding from the University of South Africa. 

• Dr Rudolph is grateful to the Government of Tristan da Cunha, which is responsible for managing the conservation of Gough Island, for permitting them to do scientific work on the island. 

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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