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13 December 2023 | Story Anthony Mthembu | Photo Siyabonga Mazibuko and Anthony Mthembu
Sharon Pinky Kekana
Sharon Pinky Kekana: Deputy Minister in the Presidency for Planning, Monitoring and Evaluation.

The Gender Equality and Anti-Discrimination Office (GEADO) at the University of the Free State (UFS), in collaboration with the Central University of Technology (CUT), recently concluded its fourth bi-annual Gender Practitioners Community of Practice (CoP) conference in Clarens. The event, held from 28 to 30 November 2023, drew participation from gender practitioners representing all 26 Universities across the country. Distinguished guest speaker, Sharon Pinky Kekana, Deputy Minister in the Presidency for Planning, Monitoring and Evaluation, added valuable insights to the discussions.

Tumelo Rasebopye, Chairperson of the Gender Practitioners Community of Practice (CoP), outlined the conference’s key objectives, emphasising the need for thorough and robust engagement on issues raised in previous gatherings and the provision of essential tools for practitioners to implement upon their return to their institutions. Rasebopye stressed, ‘Part of the conference is to ensure that we engage in developing a common understanding and act at a baseline level to address the dynamics in our institutions.’’

The themes explored throughout the Conference

The conference delved into various themes through panel discussions and guest speaker sessions, covering topics such as masculinity, culture, and consent. However, the primary focus was on Gender-Based Violence and Femicide (GBVF), particularly pertinent during the 16 Days of Activism for No Violence against Women and Children.’ Kekana, in her address, considered the conference theme, ‘Accelerating actions to end gender-based violence & femicide: leaving no one behind,’ as a call to action. She urged attendees to continue to raise awareness about the devastating impact of GBVF on women, children and the nation as a whole, citing alarming statistics of 969 women murdered in the first three months of the year. 

Advocate Brenda Madumise, Co-Founder of the Wise Collective, highlighted flaws in the national justice system, pointing to prolonged sexual assault cases and the trauma inflicted on survivors during the waiting period.

Resolutions

Reflecting on the conference, Kekana deemed the discussions as an eye-opener, stressing an integrated approach involving various societal entities, including the church and religious leaders. The gender practitioners pledged to collaborate with groups such as the Student Representative Council (SRC) within their institutions to foster inclusivity.  Rasebopye affirmed, ‘’Our existence is fundamental towards the transformation of higher education, and these conferences will inform the necessary actions towards that course.’’

The GEADO, in partnership with CUT, continues to champion gender equality through informed and actionable discussions. The conference not only raised awareness about GBVF but also galvanized gender practitioners to play an active role in fostering inclusive environments within higher education institutions.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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