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11 July 2023 | Story André Damons | Photo Supplied
Dr Mirriam Moleko
Dr Mirriam Moleko, a lecturer in the Department of Mathematics, Natural Sciences, and Technology Education in the UFS Faculty of Education, participated in the National Research Foundation’s Black Academics Advancement Programme fellowship and got the opportunity to visit universities and schools in the USA for three weeks.

After completing the National Research Foundation’s Black Academics Advancement Programme (BAAP) fellowship, a lecturer from the University of the Free State (UFS) now wants to train more teachers on issues of access and inclusivity in different mathematics settings. She also wants to establish a centre for access and inclusivity to promote quality teaching that caters to a diverse learner population.

Dr Mirriam Moleko, a lecturer in the UFS’s Department of Mathematics, Natural Sciences, and Technology Education in the Faculty of Education, participated in the BAAP fellowship, an initiative of the National Research Foundation (NRF) and the FirstRand Foundation (FRF), from 2021 to 2022. She also got the opportunity to visit universities and schools in the USA for three weeks.

Supporting emerging academics

Dr Moleko says the BAAP is a prestigious NRF programme which supports well-structured research projects with achievable aims, sound methodologies, and demonstrated prudent use of funds. The programme supports emerging academics to ensure that they develop strong research skills, collaborate with prolific scholars in their fields, visit other universities abroad, give public lectures, and attend international conferences to establish an international footprint.

“The programme allows the candidates awarded the grant to focus on research for two years” she says. “I managed to run my teacher community research project successfully during this period. My goal as an academic and a researcher is to produce work that teachers can relate to and be able to apply in their profession. I have always aspired to empower teachers to be knowledgeable and resourceful”.

“Furthermore, my goal is to strive to partake in critical conversations that are taking place within the mathematics education field, and to contribute my skills and knowledge in addressing the existing challenges, thus being part of the solution. I believe the skills that I have gained on how to conduct quality research will assist me in achieving my goals,” she added.

Benefit from funding

During the period of her fellowship she learned about forming partnerships and collaborating with other scholars in her field, which she believes is an important skill to possess as a developing scholar.

Dr Moleko says the programme played a pivotal role in the attainment of numerous significant accomplishments in her professional career thus far. She also benefitted in terms of funding, which helped her undertake autonomous research and advanced training in her area of expertise, as well as facilitated engagement in collaborative research ventures with esteemed professionals and researchers, both domestically and abroad.

“The research leave that I got enabled me to successfully conceptualise, strategise, and implement a research endeavour that yielded a more profound comprehension of the research gap that I had identified within the teacher community, thus culminating in multiple publications in esteemed periodicals.

“The NRF-BAAP funding also enabled me to undertake training, thereby refining my skill set and augmenting my comprehension of intricate principles. The experience proved to be a crucial factor in my vocational growth and bolstered my aptitude for scholarly inquiry. It also afforded me the chance to engage in mentoring endeavours for fledgling researchers.”

Transformation of the Professoriate Mentoring Programme

Dr Moleko, who is part of the UFS Transformation of the Professoriate Mentoring Programme, says this programme is an excellent initiative which is aimed at preparing young academics for future promotions and offering them skills to be competitive. The programme’s goals include building strong academics who will follow in the footsteps of the university’s current leaders.

She says the programme is critical in supporting young academics by connecting them with seasoned mentors and scholars from various fields of study. It is essential for young academics in terms of maximising their learning, expanding their network, and gaining opportunities to help facilitate their growth.

“I see the programme as a catalyst for change necessary for the university to realise the desired results,” Dr Moleko says.

During her visit to the USA she spent two weeks at Boston College and the University of Rhode Island, and also visited the Center for Applied and Specialised Technology, the Paul V. Sherlock Center on Disabilities (Sherlock Center), and the TechACCESS Center.

“The purpose of my visit was to establish networks and collaborate with prolific scholars outside South Africa on research engagements. Furthermore, the visit was intended for me to meet with my international mentors in person regarding research engagements.

“During my research visit, Prof Elizabeth Dalton from Rhode Island University and a UDL specialist, and I focused on several academic conversations and demonstrations of Universal Design for Learning (UDL) strategies and approaches, as well as the sharing of many online resources available to support the implementation of UDL in inclusive settings.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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