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27 June 2023 | Story Department of Communication and Marketing | Photo Charl Devenish
Dr Abraham Matamanda and Prof Lochner Marais
UFS researchers, Dr Abraham R Matamanda, Senior Lecturer in the Department of Geography, and Prof Lochner Marais, Head of the UFS Centre for Development Support, collaborated with researchers in the UK and Brazil on a study on the impact of COVID-19 on children and young people. The study is part of the international PANEX-Youth research project.

Researchers from South Africa, the UK, and Brazil recently conducted a study on the impact of COVID-19 on children and young people, particularly those from disadvantaged households. Their research highlights that the pandemic has deepened existing inequalities, with children and young people’s voices and needs not being considered in policy decisions.

The study conducted by researchers from the University of the Free State (UFS) and the University of Fort Hare in South Africa; the University College London, the University of Birmingham, and Nottingham Trent University in the UK; and the University of São Paulo in Brazil, found that pandemic policy decisions largely ignored young people’s needs, resulting in long-term losses.

Educational inequalities

The report, titled International and National Overviews of the impact of COVID-19 on Education, Food and Play/Leisure and Related Adaptations, outlines how slow government action and policy gaps in efforts to stop the spread of COVID-19 have had a negative impact on children and young people’s health and welfare.

South Africa has been one of the countries hardest hit by COVID-19, and the study shows that due to social isolation and economic disruption caused by lockdowns, children and young people’s education has been stunted, their access to nutritious food has been reduced, and their ability to develop socially through play has been significantly restricted. The impact was worst for those living in disadvantaged poor households.

The study, which is part of the first stage of the PANEX-Youth research project, is divided into two volumes: the ‘Long Report’, highlighting the wider impact of the pandemic on children across the world, while the ‘Short Report’ drills down on the impact on three countries, namely the UK, South Africa, and Brazil.

Further insights from the study show that the digital divide has compounded educational inequalities as education has moved online during the pandemic, with households and regions with insufficient internet access falling behind. Collectively, and combined with the continuing cost-of-living crisis, the researchers believe that these disadvantages are likely to have detrimental consequences for children and young people in the short and long term, with many not yet visible.

Future pandemic planning

The team – which includes UFS researchers, Dr Abraham R Matamanda, Senior Lecturer in the Department of Geography, and Prof Lochner Marais, Head of the UFS Centre for Development Support – expects that policy gaps during the pandemic will negatively impact young people’s professional life trajectories, healthy lifestyles, mental well-being, educational opportunities, and self-confidence.

The team put together five recommendations to ensure that children’s well-being is incorporated into any future pandemic planning. These suggestions include:

  • The need to keep children and young people at the centre of pandemic preparedness efforts.
  • More priority and attention given to the hidden voices and experiences of young people, and particularly those from monetary poor households.
  • Greater recognition that schools play an important, central role as life and care hubs.
  • Greater recognition of play and leisure as rights that are fundamental to children and young people’s development.
  • More structured and systemic responses to multiple dimensions of risk from local and national responses are recommended, based on a rigorous assessment of what worked and failed during the pandemic.

Adapting in the post-pandemic period

Prof Lauren Andres, Professor of Planning and Urban Transformations at the University College London – also the lead author of the report – said: “COVID-19 exposed and exacerbated inequalities that already existed prior to the pandemic. Children and young people’s voices and needs were not heard and accounted for. Our research shows that because of policy gaps and slow government action during the pandemic, disadvantaged children and young people are now facing serious consequences that could be with them for a long time, both here in the UK and around the world.”

According to Dr Matamanda, “The COVID-19 pandemic showed the lack of understanding of what children and young people need in their daily lives. During the pandemic, the rights of children and young people, especially play/leisure, accessing adequate food and education, seemed to be overlooked or least prioritised. This was evident from the slow and inconsistent COVID-19 government policies and strategies that failed to acknowledge the networks and value chains through which children and young people are supported. In this way, our research shows the gaps and inequalities created and widened among children and young people in South Africa, especially those from disadvantaged households who have now been left behind and are grappling to adapt in the post-pandemic period.”

Read the full report here: https://panexyouth.com/

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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