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HUMAN RIGHTS MONTH: Safety is not a privilege, it’s a right

29 March 2023 | Story Valentino Ndaba | Photo Valentino Ndaba

Human Rights UFS news — On 22 March 2023 students gathered on the Bloemfontein Campus for a celebration honouring Human Rights Day.

“As people we have the right to feel safe within the environment in which we live, no matter the circumstances. We cannot walk on the streets being fearful of what might transpire. We have the SAPS which has the constitutional obligation to make sure we feel safe. On campus as students, we also have access to Protection Services, which is tasked with ensuring our safety. It is crucial to understand that we have this section 12 right to safety, because safety is not a privilege, it’s a right,” said Lutho Makhofola during a human rights celebration held on the University of the Free State’s Bloemfontein Campus on 22 March 2023.

Lutho, a fourth year LLB student, is one of many Human Rights ambassadors who are part of the Free State Centre for Human Rights (FSCHR) which hosted the Human Rights Day celebration. The ambassadors led a dialogue with other fellow students under the national theme: ‘Consolidating and Sustaining Human Rights Culture into the Future’. In addition to robust discussions, students also tested their knowledge of the with a quiz before signing a pledge committing themselves to becoming livelong advocates for human rights.

Remembering 1960

Dr Annelie De Man, Coordinator in the Advocacy Division of the FSCHR, said the event was about celebrating the present while reflecting on the past. “The aim is to raise awareness around matters of human rights in celebration of Human Rights Day observed on 21 March.”

Human Rights Day in South Africa commemorates the Sharpeville Massacre which took place on 21 March 1960 where 69 died and 180 were injured when police opened fire on a crowd that had gathered to peacefully protest the pass laws. We now have the opportunity to contemplate on South Africa’s road to democracy, the realisation of change, and the advancement of human rights awareness both in the academic setting and society at large since this significant day in our nation's history unfolded 63 years ago.

Significance for students

According to Limeque Redgard, Student Assistant at the FSCHR and a former Human Rights ambassador, the purpose of the FSCHR Human Rights Day commemorative event was to inform and educate students about their rights, particularly the rights that apply to the university setting, to encourage reflection on those rights and how to exercise them responsibly.

“I believe that such events are important for students because we are in such a diverse space within the university, therefore such events bring us together for a common purpose and allow us to celebrate each other's diversity. Furthermore, the goal is to equip students for the world.”

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

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