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10 November 2023 | Story Ouma Ngoepe | Photo SUPPLIED
Liezl Geldenhuys (ZZ2), Mellisa Pringle (Lasec), Ouma Ngoepe (CMBG), Prof Maryna de Wit (SFSD), Dr Mariana Erasmus (CMBG), Bernadine Taljaard (ZZ2), Khezwo Nematshema (SFSD), Shahiëda Cloete (SFSD), Jan Andries Viktor (SFSD), Vuyelwa Nkoi (SFSD).
Liezl Geldenhuys (ZZ2), Mellisa Pringle (Lasec), Ouma Ngoepe (CMBG), Prof Maryna de Wit (SFSD), Dr Mariana Erasmus (CMBG), Bernadine Taljaard (ZZ2), Khezwo Nematshema (SFSD), Shahiëda Cloete (SFSD), Jan Andries Viktor (SFSD), Vuyelwa Nkoi (SFSD).

The Centre for Mineral Biogeochemistry (CMBG) at the University of the Free State (UFS) was part of another successful Tritech National Science and Technology Fair 2023 – an exciting STEM (Science, Technology, Engineering, and Mathematics) research competition.

The UFS has partnered with Tritech and other sponsors since 2021 to bridge the gap between high school and tertiary education. Tritech, which started in 2008 and is open to all Grade 7-12 learners, aims to equip them for tertiary education by introducing them to scientific research and incorporating modern technology in research. This is an annual competition that starts at the regional level and goes all the way to the national level, with the national competition held at the Merensky High School, in Tzaneen, Limpopo from 20-21 October 2023.

Schools from across the country take part in the fair, but learners compete in groups rather than schools. 

Every year the Tritech Nationals are divided into four main activities over the weekend: 
  1. On the Friday afternoon the learners present their STEM projects in which they have identified a problem in a community, do research to find a solution, do experiments to test if the solution will solve the problem, then test the solution in the community, and lastly, present their findings to a group of judges and learners in similar fields. Fields include Life Sciences, Engineering and Design, Maths, Science and Technology, Environmental and Social Sciences, Health Sciences and Agricultural Sciences.
  2. Friday evening is usually a fun activity for the learners.
  3. On Saturday morning the learners are exposed to work-related activities that give them insight into professions they could pursue in the science field. This activity is sponsored and presented by the UFS. 
  4. The last activity of the weekend is the prize-giving on Saturday afternoon where the learners get rewarded for the quality of their projects and honour, celebrate, and encourage excellence. 

“Every year the CMBG includes different departments from the UFS in alignment with the theme for the event, to ignite a lasting passion for innovation toward promising careers in the STEM fields. In 2022 the theme for Tritech was “Crime Scene Investigators” and the CMBG team created a very realistic crime scene and laboratory setup to teach the learners about Forensic Science. The learners scored our CSI activity as the best for the weekend and we knew that for the 2023 Nationals, we had our work cut out to do even better,” says Dr Erasmus. 

Learning about food health and safety

This year, Prof Maryna de Wit and her students from the Department of Sustainable Food Systems and Development (SFSD) joined the CMBG team, to introduce learners to food health and safety, food preservation, food systems and development, as well as sensory analyses. 

Island, shipwrecks, and wilderness survival

Dr Mariana Erasmus, Deputy Director of the Centre for Mineral Biogeochemistry (CMBG), spearheads the Tritech team from the UFS. CMBG, as part of its community outreach programme, is not only a sponsor of the event but is also the organiser of the main activity together with another UFS department. 

Dr Erasmus says the theme for Tritech 2023 was “Survival MasterChef”, where for the two activity events, the Tritech learners were “stranded” on an island. This exercise was a great way to promote leadership qualities, encourage creativity and confidence, promote teamwork and active communication, and increase critical thinking in learners, while they got to know more about food health and safety practices.

“It was all island, shipwrecks, and wilderness survival at this year’s event where learners had to survive after being ‘stranded’ on an island. To escape, the learners had to build a boat and while they waited to be rescued, they needed to adapt to island life to survive by preparing healthy meals, as well as preparing meals and drinks to treat dehydration and scurvy,” says Dr Erasmus. 

“During the prize-giving, some of the learners received shadowing opportunities at the UFS and other sponsors to advance their education. Bronze, silver, and gold medals, together with participation certificates, were awarded to other deserving learners.” 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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