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The first clinical PhD in nuclear medicine completed at the UFS

18 April 2024 | Story Andre Damons | Photo Charl Devenish

Dr Osayande Evbuomwan, Senior Lecturer and Medical Specialist in the Department of Nuclear Medicine, Faculty of Health Sciences, at the University of the Free State (UFS), graduated with the first clinical PhD in nuclear medicine completed at the UFS.

He graduated on Thursday (18 April 2024) at the university’s autumn graduation ceremonies when the Faculty of Health Sciences conferred degrees on its graduation class of 2024.

Dr Evbuomwan, the man behind his department using Lutetium 177 PSMA (Lu-177 PSMA) therapy and now Actinium 225 PSMA therapy to treatment metastatic castrate resistant prostate cancer (MCRPC) – an advanced stage prostate cancer, said his PhD is about using a special radiopharmaceutical called Technetium 99m ECDG to detect active disease in the joints of patients with rheumatoid arthritis (RA).

More opportunities for similar degrees

This research has won him the Society of Nuclear Medicine and Molecular Imaging (SNMMI) International Best Abstract Award for South Africa during last year’s SNMMI 2023 Annual Meeting in the US.

“I am very grateful, and at the same time, proud about this achievement (his PhD). This qualification will definitely give more opportunities for further similar degrees at the department. So yes, I feel very happy and fulfilled.

“Rheumatoid arthritis is a debilitating disease with associated morbidity that can lead to serious joint deformity and destruction. The need for an investigation with a very high diagnostic accuracy in detecting active disease is needed, especially in the detection of subclinical disease. Few prior studies in the literature had shown promising results with Tc 99m ECDG imaging in this regard. So, we decided to conduct a proper prospective study to test this hypothesis,” says Dr Evbuomwan.

This research, he explains, was also aimed at finding out if the new nuclear medicine radiopharmaceutical for the identification of active disease in patients with rheumatoid arthritis can also offer prognostic information. This aspect of the study concluded that this particular radiopharmaceutical (Tc – 99m ECDG) is highly sensitive in identifying synovitis (inflammation of the membrane that protects joints) and is capable of offering prognostic information in patients with rheumatoid arthritis.

This was the first prospective study to assess the prognostic value of this radiopharmaceutical in patients with rheumatoid arthritis, Dr Evbuomwan says.

Researching theranostics in the future

According to him, he had a smooth journey to completing his PhD – something he contributes to support from the fantastic team of three supervisors, the assistant who prepared the radiopharmaceutical, the rheumatology department, the radiographers and nurses at the Department of Nuclear Medicine, and most importantly, his wife and two daughters.

His passion for research, growth and the practice of nuclear medicine were his major motivators on this journey.

Dr Evbuomwan is currently looking at the possibility of starting research on theranostics. The only stumbling block for now, he says, is that the department still does not have a PET/CT camera, as this is very vital in today’s nuclear medicine practice. However, together with the Free State Department of Health, they are working hard to secure one.

“I now want to focus on nuclear medicine therapy and its promotion. This includes both imaging and treatment (theranostics) of certain cancers, most especially prostate cancer, neuroendocrine neoplasms, thyroid cancers and the neuroectodermal tumours. I also want to focus on being involved with the training of more registrars at the department of nuclear medicine and increasing the awareness of nuclear medicine amongst colleagues in the Free State,” says Dr Evbuomwan about his future plans.

News Archive

Young researchers are equipped to participate in projects relevant in global context

2017-09-05

This group of early career researchers received bioinformatics
training in Worcester in the UK from Dr Diane Saunders of the
John Innes Centre in the UK.
Photo: Supplied

The interdisciplinary field that develops methods and software tools to understand biological data is known as bioinformatics. According to Dr Renée Prins, a research fellow in the Department of Plant Sciences at the University of the Free State, there are few tertiary institutions in South Africa that offer a postgraduate degree in Bioinformatics.

“Most institutions focus either on humans, human diseases, forest trees and their pathogens. They usually do not have spare capacity to assist researchers, for instance, those working on crops in the agricultural sector,” Dr Prins said.

Big data sets need significant skills
With the advancements made in genomics such as high throughput DNA marker platforms and next-generation sequencing technologies, the data sets biologists have to deal with have grown massively big and cannot be dealt with unless you have significant computer skills.

Dr Prins believes that all young researchers need some level of training in this field to be effective in future. The British Council Researcher Links, being run by the Newton Fund, gives early career researchers across selected partner countries the opportunity to form international connections through fully funded workshops and travel grants. Dr Prins made use of this opportunity and with the assistance of the Department of Research Development at the UFS, she arranged for Dr Diane Saunders of the John Innes Centre in the UK, a bioinformatician of note, to present training to a group of 20 early career researchers in Worcester in the UK.

Providing training with Dr Saunders were two other bioinformaticians from the UK, Dr Burkhard Steuernagel (John Innes Centre) and Dr Robert Davey (Earlham Institute). From the UFS side, Eleanor van der Westhuizen and Dr Henriëtte van den Berg (former UFS academic) acted as mentors, providing guidance on funding opportunities and career development skills.

Participating in projects in a global context
The researchers attending the training came from research institutions or academia, and they work involving plants (predominantly wheat) or plant pathogens. A limited number of participants from the commercial sector, including private South African companies focusing on plant breeding and molecular genetics lab work on agriculturally important crops also benefited from the training.

“Tertiary institutions in South Africa have the obligation to ensure that young scientists are equipped with bioinformatics skills. If they are not equipped with the necessary skills, they will not be able to participate in research projects that are relevant in a global context,” said Dr Prins.

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