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The first clinical PhD in nuclear medicine completed at the UFS

18 April 2024 | Story Andre Damons | Photo Charl Devenish

Dr Osayande Evbuomwan, Senior Lecturer and Medical Specialist in the Department of Nuclear Medicine, Faculty of Health Sciences, at the University of the Free State (UFS), graduated with the first clinical PhD in nuclear medicine completed at the UFS.

He graduated on Thursday (18 April 2024) at the university’s autumn graduation ceremonies when the Faculty of Health Sciences conferred degrees on its graduation class of 2024.

Dr Evbuomwan, the man behind his department using Lutetium 177 PSMA (Lu-177 PSMA) therapy and now Actinium 225 PSMA therapy to treatment metastatic castrate resistant prostate cancer (MCRPC) – an advanced stage prostate cancer, said his PhD is about using a special radiopharmaceutical called Technetium 99m ECDG to detect active disease in the joints of patients with rheumatoid arthritis (RA).

More opportunities for similar degrees

This research has won him the Society of Nuclear Medicine and Molecular Imaging (SNMMI) International Best Abstract Award for South Africa during last year’s SNMMI 2023 Annual Meeting in the US.

“I am very grateful, and at the same time, proud about this achievement (his PhD). This qualification will definitely give more opportunities for further similar degrees at the department. So yes, I feel very happy and fulfilled.

“Rheumatoid arthritis is a debilitating disease with associated morbidity that can lead to serious joint deformity and destruction. The need for an investigation with a very high diagnostic accuracy in detecting active disease is needed, especially in the detection of subclinical disease. Few prior studies in the literature had shown promising results with Tc 99m ECDG imaging in this regard. So, we decided to conduct a proper prospective study to test this hypothesis,” says Dr Evbuomwan.

This research, he explains, was also aimed at finding out if the new nuclear medicine radiopharmaceutical for the identification of active disease in patients with rheumatoid arthritis can also offer prognostic information. This aspect of the study concluded that this particular radiopharmaceutical (Tc – 99m ECDG) is highly sensitive in identifying synovitis (inflammation of the membrane that protects joints) and is capable of offering prognostic information in patients with rheumatoid arthritis.

This was the first prospective study to assess the prognostic value of this radiopharmaceutical in patients with rheumatoid arthritis, Dr Evbuomwan says.

Researching theranostics in the future

According to him, he had a smooth journey to completing his PhD – something he contributes to support from the fantastic team of three supervisors, the assistant who prepared the radiopharmaceutical, the rheumatology department, the radiographers and nurses at the Department of Nuclear Medicine, and most importantly, his wife and two daughters.

His passion for research, growth and the practice of nuclear medicine were his major motivators on this journey.

Dr Evbuomwan is currently looking at the possibility of starting research on theranostics. The only stumbling block for now, he says, is that the department still does not have a PET/CT camera, as this is very vital in today’s nuclear medicine practice. However, together with the Free State Department of Health, they are working hard to secure one.

“I now want to focus on nuclear medicine therapy and its promotion. This includes both imaging and treatment (theranostics) of certain cancers, most especially prostate cancer, neuroendocrine neoplasms, thyroid cancers and the neuroectodermal tumours. I also want to focus on being involved with the training of more registrars at the department of nuclear medicine and increasing the awareness of nuclear medicine amongst colleagues in the Free State,” says Dr Evbuomwan about his future plans.

News Archive

Africa the birthplace of mathematics, says Prof Atangana

2017-11-17

Prof Abdon Atangana from the UFS Institute for Groundwater Studies.
Photo: Supplied

Prof Abdon Atangana from the Institute for Groundwater Studies at the University of the Free State recently received the African Award of Applied Mathematics during the International conference "African’s Days of Applied Mathematics" that was held in Errachidia, Morocco. Prof Atangana delivered the opening speech with the title "Africa was a temple of knowledge before: What happened?” The focus of the conference was to offer a forum for the promotion of mathematics and its applications in African countries.

When Europeans first came to Africa, they considered the architecture to be disorganised and thus primitive. It never occurred to them that Africans might have been using a form of mathematics that they hadn’t even discovered yet.

Africa is home to the world’s earliest known use of measuring and calculation. Thousands of years ago Africans were using numerals, algebra and geometry in daily life. “Our continent is the birthplace of both basic and advanced mathematics,” said Prof Atangana.

Africa attracted a series of immigrants who spread knowledge from this continent to the rest of the world.

Measuring and counting
In one of his examples of African mathematics knowledge Prof Atangana referred to the oldest mathematical instrument as the Lebombo bone, a baboon fibula used as a measuring instrument, which was named after the Lebombo Mountains of Swaziland. The world’s oldest evidence of advanced mathematics was also a baboon fibula that was discovered in present-day Democratic Republic of Congo.

Another example he used is the manuscripts in the libraries of the Sankoré University, one of the world’s oldest tertiary institutions. This university in Timbuktu, Mali, is full of manuscripts mainly written in Ajami in the 1200s AD. “When Europeans and Western Asians began visiting and colonising Mali between the 1300s and 1800s, Malians hid the manuscripts in basements, attics and underground, fearing destruction or theft by foreigners. This was certainly a good idea, given the Europeans' history of destroying texts in Kemet and other areas of the continent. Many of the scripts were mathematical and astronomical in nature. In recent years, as many as 700 000 scripts have been rediscovered and attest to the continuous knowledge of advanced mathematics and science in Africa well before European colonisation.

Fractal geometry
“One of Africa’s major achievements was the advanced knowledge of fractal geometry. This knowledge is found in a wide aspect of Africa life: from art, social design structures, architecture, to games, trade and divination systems.

“The binary numeral system was also widely known through Africa before it was known throughout much of the world. There is a theory that it could have influenced Western geometry, which led to the development of digital computers,” he said.

“Can Africa rise again?” Prof Atangana believes it can.

He concluded with a plea to fellow African researchers to do research that will build towards a new Africa.

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