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The first clinical PhD in nuclear medicine completed at the UFS

18 April 2024 | Story Andre Damons | Photo Charl Devenish

Dr Osayande Evbuomwan, Senior Lecturer and Medical Specialist in the Department of Nuclear Medicine, Faculty of Health Sciences, at the University of the Free State (UFS), graduated with the first clinical PhD in nuclear medicine completed at the UFS.

He graduated on Thursday (18 April 2024) at the university’s autumn graduation ceremonies when the Faculty of Health Sciences conferred degrees on its graduation class of 2024.

Dr Evbuomwan, the man behind his department using Lutetium 177 PSMA (Lu-177 PSMA) therapy and now Actinium 225 PSMA therapy to treatment metastatic castrate resistant prostate cancer (MCRPC) – an advanced stage prostate cancer, said his PhD is about using a special radiopharmaceutical called Technetium 99m ECDG to detect active disease in the joints of patients with rheumatoid arthritis (RA).

More opportunities for similar degrees

This research has won him the Society of Nuclear Medicine and Molecular Imaging (SNMMI) International Best Abstract Award for South Africa during last year’s SNMMI 2023 Annual Meeting in the US.

“I am very grateful, and at the same time, proud about this achievement (his PhD). This qualification will definitely give more opportunities for further similar degrees at the department. So yes, I feel very happy and fulfilled.

“Rheumatoid arthritis is a debilitating disease with associated morbidity that can lead to serious joint deformity and destruction. The need for an investigation with a very high diagnostic accuracy in detecting active disease is needed, especially in the detection of subclinical disease. Few prior studies in the literature had shown promising results with Tc 99m ECDG imaging in this regard. So, we decided to conduct a proper prospective study to test this hypothesis,” says Dr Evbuomwan.

This research, he explains, was also aimed at finding out if the new nuclear medicine radiopharmaceutical for the identification of active disease in patients with rheumatoid arthritis can also offer prognostic information. This aspect of the study concluded that this particular radiopharmaceutical (Tc – 99m ECDG) is highly sensitive in identifying synovitis (inflammation of the membrane that protects joints) and is capable of offering prognostic information in patients with rheumatoid arthritis.

This was the first prospective study to assess the prognostic value of this radiopharmaceutical in patients with rheumatoid arthritis, Dr Evbuomwan says.

Researching theranostics in the future

According to him, he had a smooth journey to completing his PhD – something he contributes to support from the fantastic team of three supervisors, the assistant who prepared the radiopharmaceutical, the rheumatology department, the radiographers and nurses at the Department of Nuclear Medicine, and most importantly, his wife and two daughters.

His passion for research, growth and the practice of nuclear medicine were his major motivators on this journey.

Dr Evbuomwan is currently looking at the possibility of starting research on theranostics. The only stumbling block for now, he says, is that the department still does not have a PET/CT camera, as this is very vital in today’s nuclear medicine practice. However, together with the Free State Department of Health, they are working hard to secure one.

“I now want to focus on nuclear medicine therapy and its promotion. This includes both imaging and treatment (theranostics) of certain cancers, most especially prostate cancer, neuroendocrine neoplasms, thyroid cancers and the neuroectodermal tumours. I also want to focus on being involved with the training of more registrars at the department of nuclear medicine and increasing the awareness of nuclear medicine amongst colleagues in the Free State,” says Dr Evbuomwan about his future plans.

News Archive

Victory lies beyond the moment

2017-12-25

Mokoena learns a new skill at the Learning Festival arranged
by the Centre for Community Engagement.
Photo: Igno van Niekerk

For Mokoena it was just a regular day. Another day. Another rush. As a taxi driver you get used to the adrenaline, taking gaps, foot on the accelerator. Alert. Honking hooters. Angry drivers.

Then it came out of nowhere. A stroke. The one side of his body was going numb. What was happening? What about his job? His income? His life?

Fast-forward a few years.

I meet Mokoena at the Learning Festival arranged by the Centre for Community Engagement, in association with Bloemshelter on the University of the Free State’s Bloemfontein Campus. A reserved young man, Mokoena is busy at one of the stands where a range of people from rural communities come to learn new skills. At no cost. They then go back to teach the skills they learnt in their communities. Job creation, that’s the philosophy: as you develop, you need to develop others.

When I talk to Karen Venter, Head of Service Learning at the Centre for Community Engagement, the stories are overwhelming. “There was the lady who attended 19 workshops in two days. She went back to her community, shared her knowledge and became an entrepreneur helping others take care of themselves.”

New skills
Mokoena is also here to acquire new skills. After his stroke he was told by occupational therapy students about a project that teaches you to build your own house with raw materials. He takes out his cellphone with a sense of pride. Scrolls through some pictures: “This is my house. I built it from all kinds of things, cow manure, bottles, clay, other people’s rubbish.” The pictures show a house in a neat environment. Solid. Proud. A lot of healing came with building the house. Karen explains: “The physical work he was doing, pushing a wheelbarrow and working, but more than that – the knowledge that he could take charge, make a difference, work on a dream – the healing power of a sense of purpose. He became stronger and more confident.”

Victory
Mokoena walks back to the sewing workshop he was attending before sharing his story. The buzz continues inside the Equitas Building where artisans, entrepreneurs and UFS staff are sharing their skills. Sewing machines hum away and infrequent beeps sound from a table where an excited group of non-scientists have just completed the building of circuits. Faces light up with every beep. Hands raised. Fists clenched. Victory!

But the victory lies beyond the moment. It’s in the confidence, the learning, and the sharing that will be taking place when these people go back to their communities. Some will participate in research projects; others will benefit from curricular requirements leading students into distant communities, and others will be hosting workshops at the next Learning Festival.

And there will be more great stories. Like Mokoena’s.

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