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The first clinical PhD in nuclear medicine completed at the UFS

18 April 2024 | Story Andre Damons | Photo Charl Devenish

Dr Osayande Evbuomwan, Senior Lecturer and Medical Specialist in the Department of Nuclear Medicine, Faculty of Health Sciences, at the University of the Free State (UFS), graduated with the first clinical PhD in nuclear medicine completed at the UFS.

He graduated on Thursday (18 April 2024) at the university’s autumn graduation ceremonies when the Faculty of Health Sciences conferred degrees on its graduation class of 2024.

Dr Evbuomwan, the man behind his department using Lutetium 177 PSMA (Lu-177 PSMA) therapy and now Actinium 225 PSMA therapy to treatment metastatic castrate resistant prostate cancer (MCRPC) – an advanced stage prostate cancer, said his PhD is about using a special radiopharmaceutical called Technetium 99m ECDG to detect active disease in the joints of patients with rheumatoid arthritis (RA).

More opportunities for similar degrees

This research has won him the Society of Nuclear Medicine and Molecular Imaging (SNMMI) International Best Abstract Award for South Africa during last year’s SNMMI 2023 Annual Meeting in the US.

“I am very grateful, and at the same time, proud about this achievement (his PhD). This qualification will definitely give more opportunities for further similar degrees at the department. So yes, I feel very happy and fulfilled.

“Rheumatoid arthritis is a debilitating disease with associated morbidity that can lead to serious joint deformity and destruction. The need for an investigation with a very high diagnostic accuracy in detecting active disease is needed, especially in the detection of subclinical disease. Few prior studies in the literature had shown promising results with Tc 99m ECDG imaging in this regard. So, we decided to conduct a proper prospective study to test this hypothesis,” says Dr Evbuomwan.

This research, he explains, was also aimed at finding out if the new nuclear medicine radiopharmaceutical for the identification of active disease in patients with rheumatoid arthritis can also offer prognostic information. This aspect of the study concluded that this particular radiopharmaceutical (Tc – 99m ECDG) is highly sensitive in identifying synovitis (inflammation of the membrane that protects joints) and is capable of offering prognostic information in patients with rheumatoid arthritis.

This was the first prospective study to assess the prognostic value of this radiopharmaceutical in patients with rheumatoid arthritis, Dr Evbuomwan says.

Researching theranostics in the future

According to him, he had a smooth journey to completing his PhD – something he contributes to support from the fantastic team of three supervisors, the assistant who prepared the radiopharmaceutical, the rheumatology department, the radiographers and nurses at the Department of Nuclear Medicine, and most importantly, his wife and two daughters.

His passion for research, growth and the practice of nuclear medicine were his major motivators on this journey.

Dr Evbuomwan is currently looking at the possibility of starting research on theranostics. The only stumbling block for now, he says, is that the department still does not have a PET/CT camera, as this is very vital in today’s nuclear medicine practice. However, together with the Free State Department of Health, they are working hard to secure one.

“I now want to focus on nuclear medicine therapy and its promotion. This includes both imaging and treatment (theranostics) of certain cancers, most especially prostate cancer, neuroendocrine neoplasms, thyroid cancers and the neuroectodermal tumours. I also want to focus on being involved with the training of more registrars at the department of nuclear medicine and increasing the awareness of nuclear medicine amongst colleagues in the Free State,” says Dr Evbuomwan about his future plans.

News Archive

What did they learn at Stanford University?

2015-11-04

Members of the cohort with the
Vice-Chancellor and Rector of the UFS,
Prof Jonathan Jansen

Every year, since 2012, six second-year Kovsies are selected to take part in the elite Stanford Sophomore College Programme at the prestigious Stanford University in the United States. The University of the Free State and Oxford University are the only non-Stanford members of this exclusive course.

From 31 August to 15 September 2015, Farzaana Adam, Cornel Vermaak, Precious Mokwala, Tristan Van Der Spuy, Anje Venter, and Naushad Mayat undertook a three-week long academic exploration of multidisciplinary topics. These students attended seminars aligned with their respective fields of study from which they accumulated a wealth of knowledge.

This year’s cohort reflects on what they learned at Stanford University:

The significance of analyzing technology

One of the key points gathered by Farzaana Adam from the seminar, ‘Great Ideas in Computer Science’, was the necessity not to approach technology at face value. “Computer science goes beyond the technological products and social networks. By analysing the concepts underlying these technologies, many discoveries which have benefitted many fields of study have been made possible.”

Critical thinking in Arts and Science

“By combining different fields of study, one can obtain a greater perspective on the relevant fields,” said Cornel Vermaak, about what he garnered from a seminar titled ‘An Exploration of Art Materials: An intersection between the Arts and Science’. “This greater perspective enables one to evaluate problems critically,” he added.

Visual media substitutes oral narratives

“We were also taught different ways in which to interpret images, and how images influence society. Photography is a way to tell a story without actually having to say anything,” reflected Precious Mokwala, on ‘Photography: truth or fiction’

A lesson in business economics

Tristan Van Der Spuy received pointers pertaining to the stock exchange market in ‘A Random Walk Down Wall Street’. “We looked at stock markets, and what influenced the stock prices of multiple companies, taking note of what should be looked at when investing in a company.”

Race relations and representation

‘The New Millenium Mix: Crossings between Race and Culture’ exposed Anje Venter to a global perspective on identity. “We explored the new generation of people that have mixed races and cultures, and how they are depicted in media and art. We analysed the discrepancies and stereotypes of these depictions through film, novel, and short story studies, as well as through field trips to museums and art exhibitions.”

Overcoming the HIV/AIDS endemic

Naushad Mayat realised that “more teamwork and transparency between governments, chemists, social workers, and clinicians will be required for us to stem the flow [of HIV/AIDS],” in view of what he learned in a seminar on ‘HIV/AIDS: A Response to the AIDS Epidemic in the Bay Area’. “It is a daunting task. For the current generation of youth to tackle this epidemic now, we must stand together and be counted,” he added.

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