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The first clinical PhD in nuclear medicine completed at the UFS

18 April 2024 | Story Andre Damons | Photo Charl Devenish

Dr Osayande Evbuomwan, Senior Lecturer and Medical Specialist in the Department of Nuclear Medicine, Faculty of Health Sciences, at the University of the Free State (UFS), graduated with the first clinical PhD in nuclear medicine completed at the UFS.

He graduated on Thursday (18 April 2024) at the university’s autumn graduation ceremonies when the Faculty of Health Sciences conferred degrees on its graduation class of 2024.

Dr Evbuomwan, the man behind his department using Lutetium 177 PSMA (Lu-177 PSMA) therapy and now Actinium 225 PSMA therapy to treatment metastatic castrate resistant prostate cancer (MCRPC) – an advanced stage prostate cancer, said his PhD is about using a special radiopharmaceutical called Technetium 99m ECDG to detect active disease in the joints of patients with rheumatoid arthritis (RA).

More opportunities for similar degrees

This research has won him the Society of Nuclear Medicine and Molecular Imaging (SNMMI) International Best Abstract Award for South Africa during last year’s SNMMI 2023 Annual Meeting in the US.

“I am very grateful, and at the same time, proud about this achievement (his PhD). This qualification will definitely give more opportunities for further similar degrees at the department. So yes, I feel very happy and fulfilled.

“Rheumatoid arthritis is a debilitating disease with associated morbidity that can lead to serious joint deformity and destruction. The need for an investigation with a very high diagnostic accuracy in detecting active disease is needed, especially in the detection of subclinical disease. Few prior studies in the literature had shown promising results with Tc 99m ECDG imaging in this regard. So, we decided to conduct a proper prospective study to test this hypothesis,” says Dr Evbuomwan.

This research, he explains, was also aimed at finding out if the new nuclear medicine radiopharmaceutical for the identification of active disease in patients with rheumatoid arthritis can also offer prognostic information. This aspect of the study concluded that this particular radiopharmaceutical (Tc – 99m ECDG) is highly sensitive in identifying synovitis (inflammation of the membrane that protects joints) and is capable of offering prognostic information in patients with rheumatoid arthritis.

This was the first prospective study to assess the prognostic value of this radiopharmaceutical in patients with rheumatoid arthritis, Dr Evbuomwan says.

Researching theranostics in the future

According to him, he had a smooth journey to completing his PhD – something he contributes to support from the fantastic team of three supervisors, the assistant who prepared the radiopharmaceutical, the rheumatology department, the radiographers and nurses at the Department of Nuclear Medicine, and most importantly, his wife and two daughters.

His passion for research, growth and the practice of nuclear medicine were his major motivators on this journey.

Dr Evbuomwan is currently looking at the possibility of starting research on theranostics. The only stumbling block for now, he says, is that the department still does not have a PET/CT camera, as this is very vital in today’s nuclear medicine practice. However, together with the Free State Department of Health, they are working hard to secure one.

“I now want to focus on nuclear medicine therapy and its promotion. This includes both imaging and treatment (theranostics) of certain cancers, most especially prostate cancer, neuroendocrine neoplasms, thyroid cancers and the neuroectodermal tumours. I also want to focus on being involved with the training of more registrars at the department of nuclear medicine and increasing the awareness of nuclear medicine amongst colleagues in the Free State,” says Dr Evbuomwan about his future plans.

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Graduates challenged to fulfil their leadership obligations

2015-12-14

Procession frontline: seen making their way to the graduation ceremony are from left: Dr Khotso Mokhele (Chancellor of the UFS), Prof Busisiwe Bhengu (Chairperson of the South African Nursing Council), and Prof Jonathan Jansen (Vice-Chancellor of the UFS).
Photo: Johan Roux

The time for one-dimensional discourse was over, said Professor Busisiwe Bhengu, the guest speaker at this year’s Summer Graduation. Practical implementation of change was the step forward in forging the path into a brighter South Africa future.

During both the morning and afternoon ceremonies held at the University of the Free State (UFS) Bloemfontein Campus on 10 December 2015, the Chairperson of the South African Nursing Council, and Associate Professor at the University of KwaZulu-Natal, challenged the newly-graduated alumni to rise to the occasion, and be a part of the solution to our country’s diverse challenges.

Some of the pervasive hardships she highlighted were human immunodeficiency virus (HIV) and tuberculosis (TB), the escalating number of orphans and child-headed households, and the human resource shortages resulting from an ageing generation which is exiting the employment system through retirement.

Prior to dissolving the congregations, Dr Khotso Mokhele, the Chancellor of the UFS, said: “I was caught by the leadership challenge she [Prof Bhengu] threw out at the graduates because we indeed need courageous, creative and innovative leaders moving forward,” he said.

Dr Mokhele touched on South Africa’s dwindling economy, the leadership issues engulfing the government currently, the #FeesMustFall movement, and how students led a difficult dialogue and dictated the country’s trajectory as regards education, as well as the water scarcity we are facing. In closing, he warned that the graduates had lost the luxury of feeling led because of the fact that they now have a leadership obligation to fulfil.

Highlights of the day

Amongst 102 graduates from the UFS School of Medicine were two brothers from the Free State, Johann and Rudi Westraad who followed each other’s passion to become doctors.

Deputy Registrar at the UFS, Elna Van Pletzen, graduated with a Master’s in Higher Education Studies. Her thesis titled ”The implications of current legislative changes for academic freedom and institutional autonomy of South African higher education institutions”, focused on the amendment of Higher Education and Training Laws Amendment Act of 2012. In it, she tackled the subjects of academic freedom and the relationship between government and higher education institutions. Coincidently, her research was produced at a time when the subject of university autonomy was on the national agenda.

The occasion was not only a celebration of the students; teachers were also recognised for their dedication to quality education. Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS congratulated Dr Louise van den Berg (Faculty of Health Sciences) as well as Naquita Fernandes and Salomien Boshoff (both from the Faculty of Economic and Management Sciences) for their outstanding achievements. At a recent ceremony, Dr Van den Berg received the Vice-Chancellor’s Award for an individual teacher, and the Vice-Chancellor’s Award for the best teaching team was presented to Fernandes and Boshoff.

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