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The first clinical PhD in nuclear medicine completed at the UFS

18 April 2024 | Story Andre Damons | Photo Charl Devenish

Dr Osayande Evbuomwan, Senior Lecturer and Medical Specialist in the Department of Nuclear Medicine, Faculty of Health Sciences, at the University of the Free State (UFS), graduated with the first clinical PhD in nuclear medicine completed at the UFS.

He graduated on Thursday (18 April 2024) at the university’s autumn graduation ceremonies when the Faculty of Health Sciences conferred degrees on its graduation class of 2024.

Dr Evbuomwan, the man behind his department using Lutetium 177 PSMA (Lu-177 PSMA) therapy and now Actinium 225 PSMA therapy to treatment metastatic castrate resistant prostate cancer (MCRPC) – an advanced stage prostate cancer, said his PhD is about using a special radiopharmaceutical called Technetium 99m ECDG to detect active disease in the joints of patients with rheumatoid arthritis (RA).

More opportunities for similar degrees

This research has won him the Society of Nuclear Medicine and Molecular Imaging (SNMMI) International Best Abstract Award for South Africa during last year’s SNMMI 2023 Annual Meeting in the US.

“I am very grateful, and at the same time, proud about this achievement (his PhD). This qualification will definitely give more opportunities for further similar degrees at the department. So yes, I feel very happy and fulfilled.

“Rheumatoid arthritis is a debilitating disease with associated morbidity that can lead to serious joint deformity and destruction. The need for an investigation with a very high diagnostic accuracy in detecting active disease is needed, especially in the detection of subclinical disease. Few prior studies in the literature had shown promising results with Tc 99m ECDG imaging in this regard. So, we decided to conduct a proper prospective study to test this hypothesis,” says Dr Evbuomwan.

This research, he explains, was also aimed at finding out if the new nuclear medicine radiopharmaceutical for the identification of active disease in patients with rheumatoid arthritis can also offer prognostic information. This aspect of the study concluded that this particular radiopharmaceutical (Tc – 99m ECDG) is highly sensitive in identifying synovitis (inflammation of the membrane that protects joints) and is capable of offering prognostic information in patients with rheumatoid arthritis.

This was the first prospective study to assess the prognostic value of this radiopharmaceutical in patients with rheumatoid arthritis, Dr Evbuomwan says.

Researching theranostics in the future

According to him, he had a smooth journey to completing his PhD – something he contributes to support from the fantastic team of three supervisors, the assistant who prepared the radiopharmaceutical, the rheumatology department, the radiographers and nurses at the Department of Nuclear Medicine, and most importantly, his wife and two daughters.

His passion for research, growth and the practice of nuclear medicine were his major motivators on this journey.

Dr Evbuomwan is currently looking at the possibility of starting research on theranostics. The only stumbling block for now, he says, is that the department still does not have a PET/CT camera, as this is very vital in today’s nuclear medicine practice. However, together with the Free State Department of Health, they are working hard to secure one.

“I now want to focus on nuclear medicine therapy and its promotion. This includes both imaging and treatment (theranostics) of certain cancers, most especially prostate cancer, neuroendocrine neoplasms, thyroid cancers and the neuroectodermal tumours. I also want to focus on being involved with the training of more registrars at the department of nuclear medicine and increasing the awareness of nuclear medicine amongst colleagues in the Free State,” says Dr Evbuomwan about his future plans.

News Archive

Expansion to Physics building officially opened on Bloemfontein Campus

2016-05-06

The newly-opened addition to the Physics Building on the Bloemfontein Campus.
Photo: Charl Devenish

An extension to the Department of Physics at the University of the Free State (UFS) was officially opened on the Bloemfontein Campus on 20 April 2016.

“This started off about five years ago when we were talking about not having enough room for large classes. Prof Matie Hoffman suggested that we build a large lecture room on our parking space,” said Prof Hendrik Swart, Professor in the Department of Physics as he addressed guests at the official opening ceremony.

“A year later, we received a Sarchi Research Chair [South African Research Chairs Initiative] on Advanced and Luminescent Materials. We needed more office and laboratory space. The two ideas were combined and presented to the university’s senior management,” he added.

When the university was founded in 1904, Prof James Lyle was appointed to head up the Physics and Chemistry departments. Five years later, a single room was allocated for the Physics laboratory in the main building upon its completion. In 1947, the old Physics building was designed and constructed. Fast forward 69 years, the department has reached another milestone. Facilities accommodated by the expansion include a new telescope for astrophysics experiments, a basement for storing old equipment, as well as a sliding trap door which allows heavy goods to be elevated into the building from the ground floor. The telescope is one of the many unique features of the building given its capacity to expose graduate students to the basic techniques of radio astronomy, especially in light of the fact that the SKA (Square Kilometre Array) project which is in progress.

“Our department is extremely strong at this stage, and a bright future lies ahead,” said Prof Koos Terblans, the Head of Department. The opening also served to celebrate the 103 publications achieved by the department last year.

Dr Lis Lange, Vice-Rector: Academic is proud of the heights reached by the department to date. “The Department of Physics is undoubtedly one of the jewels in the crown of our university, and we are very proud of its developments. Universities are built on legacies, and they are also about change, which is what this department has been demonstrating.”

The expansions to the building with its top-class facilities, was constructed at a cost of R25 million – an infrastructure grant courtesy of the Department of Higher Education and Training.

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