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The first clinical PhD in nuclear medicine completed at the UFS

18 April 2024 | Story Andre Damons | Photo Charl Devenish

Dr Osayande Evbuomwan, Senior Lecturer and Medical Specialist in the Department of Nuclear Medicine, Faculty of Health Sciences, at the University of the Free State (UFS), graduated with the first clinical PhD in nuclear medicine completed at the UFS.

He graduated on Thursday (18 April 2024) at the university’s autumn graduation ceremonies when the Faculty of Health Sciences conferred degrees on its graduation class of 2024.

Dr Evbuomwan, the man behind his department using Lutetium 177 PSMA (Lu-177 PSMA) therapy and now Actinium 225 PSMA therapy to treatment metastatic castrate resistant prostate cancer (MCRPC) – an advanced stage prostate cancer, said his PhD is about using a special radiopharmaceutical called Technetium 99m ECDG to detect active disease in the joints of patients with rheumatoid arthritis (RA).

More opportunities for similar degrees

This research has won him the Society of Nuclear Medicine and Molecular Imaging (SNMMI) International Best Abstract Award for South Africa during last year’s SNMMI 2023 Annual Meeting in the US.

“I am very grateful, and at the same time, proud about this achievement (his PhD). This qualification will definitely give more opportunities for further similar degrees at the department. So yes, I feel very happy and fulfilled.

“Rheumatoid arthritis is a debilitating disease with associated morbidity that can lead to serious joint deformity and destruction. The need for an investigation with a very high diagnostic accuracy in detecting active disease is needed, especially in the detection of subclinical disease. Few prior studies in the literature had shown promising results with Tc 99m ECDG imaging in this regard. So, we decided to conduct a proper prospective study to test this hypothesis,” says Dr Evbuomwan.

This research, he explains, was also aimed at finding out if the new nuclear medicine radiopharmaceutical for the identification of active disease in patients with rheumatoid arthritis can also offer prognostic information. This aspect of the study concluded that this particular radiopharmaceutical (Tc – 99m ECDG) is highly sensitive in identifying synovitis (inflammation of the membrane that protects joints) and is capable of offering prognostic information in patients with rheumatoid arthritis.

This was the first prospective study to assess the prognostic value of this radiopharmaceutical in patients with rheumatoid arthritis, Dr Evbuomwan says.

Researching theranostics in the future

According to him, he had a smooth journey to completing his PhD – something he contributes to support from the fantastic team of three supervisors, the assistant who prepared the radiopharmaceutical, the rheumatology department, the radiographers and nurses at the Department of Nuclear Medicine, and most importantly, his wife and two daughters.

His passion for research, growth and the practice of nuclear medicine were his major motivators on this journey.

Dr Evbuomwan is currently looking at the possibility of starting research on theranostics. The only stumbling block for now, he says, is that the department still does not have a PET/CT camera, as this is very vital in today’s nuclear medicine practice. However, together with the Free State Department of Health, they are working hard to secure one.

“I now want to focus on nuclear medicine therapy and its promotion. This includes both imaging and treatment (theranostics) of certain cancers, most especially prostate cancer, neuroendocrine neoplasms, thyroid cancers and the neuroectodermal tumours. I also want to focus on being involved with the training of more registrars at the department of nuclear medicine and increasing the awareness of nuclear medicine amongst colleagues in the Free State,” says Dr Evbuomwan about his future plans.

News Archive

nGAP lecturers welcomed by the UFS academic community

2016-06-30

Description: nGAP lecturers group photo Tags: nGAP lecturers group photo

University of the Free State’s newly-appointed nGAP
lecturers. From the left, Neo Mathinya,
Phumudzo Tharaga, and Kelebogile Boleu.

The University of the Free State (UFS) was allocated six positions as part of the Department of Higher Education and Training (DHET) New Generation of Academics Programme (nGAP). Four candidates have filled positions in the Faculty of Health Sciences, Faculty of the Humanities and the Faculty of Natural and Agricultural Sciences – with two positions still vacant.

According to Minister of Higher Education and Training, Dr Blade Nzimande, nGAP is part of the Staffing South Africa's Universities Framework, which focuses on the expansion of the size and compilation of academic staff at South African universities, especially with regard to transformation. The focus of the programme is the appointment of black and coloured candidates as well as women.

The Department of Soil, Crop, and Climate Sciences in the Faculty of Natural and Agricultural Sciences welcomed two nGAP lecturers, Phumudzo Tharaga and Neo Mathinya. The Faculty was allocated four positions. Two positions are filled, while two positions in the Department of Animal and Wildlife Sciences are almost ready to be filled with exceptional candidates.

Agrometeorologist with his feet on the ground
Phumudzo Tharaga holds an MSc from the UFS, and is currently pursuing a PhD. Tharaga’s research focuses on quantifying the water use efficiency of sweet cherry orchards under different climate conditions in the Eastern Free State. Tharaga will offer his students a wealth of practical experience, which he began accumulating while working at ABSA as an agro-meteorologist, before moving on to become a senior scientist at the South African Weather Service. In 2015, Tharaga became a research technologist at the Council for Scientific and Industrial Research (CSIR) and then returned to the UFS as an nGAP candidate at the beginning of 2016.

Beynon Abrahams, nGap lecturer
at the Faculty of Heath Sciences
Department of Basic medicine

Motivated scholar turned academic
Neo Mathinya, who hails from Taung in the North West, has made the UFS her home. She received both her undergraduate and honours degrees from the university. Apart from joining the department as a lecturer under the nGAP initiative, she is currently studying for her MSc in Soil Physics. She will continue with this research when she comes to her PhD. Mathinya’s research focuses on soil salinity - the process of increasing salt content - which affects the ability of plants to take up water, a process, known as osmotic stress. She will investigate the effects of irrigation water salinity on the grain yield and quality of malt barley.

Researcher with a passion for crime prevention
Kelebogile Boleu joined the Department of Criminology in the Faculty of Humanities, with a fresh take on diversion and crime prevention. Boleu holds a BA Criminology (Hons) and is now pursuing her Master’s degree. She worked for NICRO a non-profit organisation specialising in social crime prevention and offender reintegration, with programmes that prevent young and first-time offenders from re-offending, thus reducing crime. Boleu said that her practical experience makes her lectures to third-year criminology students exciting. Boleu’s research focuses on analysing the value of pre-sentencing reports in assisting adjudicators to make well-balanced judgments in cases.

Research with a winning plan for fight against breast cancer
Beynon Abrahams joined the Department of Basic Medical Sciences in the Faculty of Health Sciences. Abrahams holds a BSc, BSc (Hons), and MSc in Medical Biosciences from the University of the Western Cape. Abrahams’ Master’s research focused on breast cancer, research on which he is building in his PhD. This doctoral research involves the exploration of P-glycoprotein, a protein expressed on cancer cell and responsible for multi-drug resistance in cancer treatment. The aim of this research is to develop a therapeutic drug treatment strategy that will improve breast cancer patient survival outcomes. Abrahams’s greater vision is to look at conventional cancer therapeutic regimens, to find ways in which they can be improved.

The nGAP initiative offers these young lecturers an opportunity for growth and development as academics, while providing them with opportunities they would have not have been exposed to otherwise.

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