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07 August 2024 | Story André Damons | Photo André Damons
Dr Alba du Toit
Dr Alba du Toit, Senior Lecturer in the Department of Sustainable Food Systems and Development, is leading the newly established Innovative ARC-DALLRD-UFS Agro-processing for Climate-smart Food System research chair at the UFS.

The Innovative Agro-processing for Climate-smart Food System research chair, one of four ARC-DALLRD-UFS research chairs recently established at the University of the Free State (UFS), will focus on innovative agro-processing technologies that could affect food and nutrition security. The chair’s work will also focus on improving food systems that can impact socioeconomic development.

In a concerted effort to address the challenges and effects of climate change in Southern Africa, the UFS, together with the Agricultural Research Council (ARC) and the Department of Agriculture, Land Reform and Rural Development (DALRRD), established four new research chairs within the Faculty of Natural and Agricultural Sciences (NAS).

The other research chairs are Climate Change and Agriculture, Agriculture Risk Financing and Sustainable Livestock Production and together with the Innovative Agro-processing for Climate-smart Food System research chair, and fall under the umbrella of climate change. They will also be part of the centre of excellence of the ARC and DALRRD on Climate Smart Agriculture.

Dr Alba du Toit, Senior Lecturer in the Department of Sustainable Food Systems and Development, will lead the Innovative Agro-processing for Climate-smart Food System research chair and says the chair allows researchers to dedicate their time and effort towards research. It consolidates expertise, resources, and facilities to strengthen the research team’s capacity and will have a strong foundation for sustainable development goals. The chair provides a hub for collaboration between the UFS, ARC and DALLRD to focus on regionally engaged research with maximum societal impact.

The chair, which officially started on 1 July, also allows researchers to do trans- and multi-disciplinary, relevant and cutting-edge research.

Nixtamalisation could transform the food system

“We believe that nixtamalisation could transform the food system. However, the consumer’s willingness to adopt and embrace new products and techniques is dependent on the success of the initiative.

“Thus, innovations in new product development must be consumer-led since the consumer is constantly evolving, making it imperative to understand consumer behaviour and motivations behind decision-making,” says Dr Du Toit.

The nixtamalisation process, she explains, is a multistep technique commonly employed in Mexico, Central America and the southern regions of the US to transform maize into food products. The nixtamalisation process alters the physicochemical, nutritional and sensory properties of maize products by increasing protein quality, improving the content of calcium, magnesium and potassium and reducing mycotoxin levels.”

According to Dr Du Toit, by using the principles of circular food design, they will develop products that could provide solutions and support the food system. It involves using processing technologies that could be applied and implemented by anyone with access to a basic kitchen.

“This would benefit rural farmers and communities, small-scale and emerging farmers to provide food for themselves and become economically active small business owners. We believed the right product could not only influence the food security and well-being of individual households but also stimulate entrepreneurial action, which could benefit the community and overcome barriers to make nixtamalisation an acceptable practice for all,” says Dr Du Toit.

Maize and sorghum

“Maize and sorghum are staple crops in South Africa that are not being utilised to their full potential. South Africa is well known for its maize production, and it is the staple for most of the population in the form of pap. However, the reliance on pap exaggerates the issues of food and nutrition insecurity because pap cooked from Super Maize Meal is deficient in nutrients and often consumed in isolation without diversification in the diet.

“Sorghum is another cereal crop that is climate-smart, drought-resistant and suited in South Africa’s arid and semi-arid areas, while it offers good nutritional value. However, most consumers are not familiar with the crop except for its application as an instant porridge.  Nixtamalisation is a process that could benefit consumers as maize and sorghum could be transformed into nutritious, safe meals directly from the farm to the fork,” explains Dr Du Toit.

Home-grown dried whole maize kernels, she continues, could be converted into safe and delicious meals in homes using basic equipment as it is widely and effectively done in Mexico by rural women. The research will determine if consumers would accept the process of nixtamalisation, whether the products would be acceptable, and if the nutritional value would be comparable to commercial products.

Some of the news consumer-acceptable products already developed, include maize chips, dehydrated phutu pap, and corndogs. Currently, the team is working on maize-milk, maize-milk frozen dessert and a custard tart. Maize products have the advantage of being lactose- and gluten-free and thus would appeal to consumers of plant-based products.

Societal impact

Dr Du Toit says she is excited about the societal impact this project will have on communities and the country and is hopeful that they will be able to influence policymakers and the industry to provide more nutritious staples that could be “game-changers” for the sake of society. She is looking forward to collaborating with DALRRD, the ARC and the grain industry to ensure that partnerships are strengthened and new opportunities are created for the staff and students.

Prof Wilna Oldewage-Theron, a Professor of Nutrition in the College of Human Sciences at Texas Tech University, will join the research chair next year as the co-leader. She has experience in community nutrition research in Africa, and her research interests include the factors contributing to household food insecurity and malnutrition in resource-poor communities. She will be focused on the nutritional benefits of soy for human health.

Prof Maryke Labuschagne, who is leading the NRF SARChI Chair in Diseases and Quality of Field Crops and who is passionate about impacting malnutrition, has been appointed as mentor for the chair.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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