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07 August 2024 | Story André Damons | Photo André Damons
Dr Alba du Toit
Dr Alba du Toit, Senior Lecturer in the Department of Sustainable Food Systems and Development, is leading the newly established Innovative ARC-DALLRD-UFS Agro-processing for Climate-smart Food System research chair at the UFS.

The Innovative Agro-processing for Climate-smart Food System research chair, one of four ARC-DALLRD-UFS research chairs recently established at the University of the Free State (UFS), will focus on innovative agro-processing technologies that could affect food and nutrition security. The chair’s work will also focus on improving food systems that can impact socioeconomic development.

In a concerted effort to address the challenges and effects of climate change in Southern Africa, the UFS, together with the Agricultural Research Council (ARC) and the Department of Agriculture, Land Reform and Rural Development (DALRRD), established four new research chairs within the Faculty of Natural and Agricultural Sciences (NAS).

The other research chairs are Climate Change and Agriculture, Agriculture Risk Financing and Sustainable Livestock Production and together with the Innovative Agro-processing for Climate-smart Food System research chair, and fall under the umbrella of climate change. They will also be part of the centre of excellence of the ARC and DALRRD on Climate Smart Agriculture.

Dr Alba du Toit, Senior Lecturer in the Department of Sustainable Food Systems and Development, will lead the Innovative Agro-processing for Climate-smart Food System research chair and says the chair allows researchers to dedicate their time and effort towards research. It consolidates expertise, resources, and facilities to strengthen the research team’s capacity and will have a strong foundation for sustainable development goals. The chair provides a hub for collaboration between the UFS, ARC and DALLRD to focus on regionally engaged research with maximum societal impact.

The chair, which officially started on 1 July, also allows researchers to do trans- and multi-disciplinary, relevant and cutting-edge research.

Nixtamalisation could transform the food system

“We believe that nixtamalisation could transform the food system. However, the consumer’s willingness to adopt and embrace new products and techniques is dependent on the success of the initiative.

“Thus, innovations in new product development must be consumer-led since the consumer is constantly evolving, making it imperative to understand consumer behaviour and motivations behind decision-making,” says Dr Du Toit.

The nixtamalisation process, she explains, is a multistep technique commonly employed in Mexico, Central America and the southern regions of the US to transform maize into food products. The nixtamalisation process alters the physicochemical, nutritional and sensory properties of maize products by increasing protein quality, improving the content of calcium, magnesium and potassium and reducing mycotoxin levels.”

According to Dr Du Toit, by using the principles of circular food design, they will develop products that could provide solutions and support the food system. It involves using processing technologies that could be applied and implemented by anyone with access to a basic kitchen.

“This would benefit rural farmers and communities, small-scale and emerging farmers to provide food for themselves and become economically active small business owners. We believed the right product could not only influence the food security and well-being of individual households but also stimulate entrepreneurial action, which could benefit the community and overcome barriers to make nixtamalisation an acceptable practice for all,” says Dr Du Toit.

Maize and sorghum

“Maize and sorghum are staple crops in South Africa that are not being utilised to their full potential. South Africa is well known for its maize production, and it is the staple for most of the population in the form of pap. However, the reliance on pap exaggerates the issues of food and nutrition insecurity because pap cooked from Super Maize Meal is deficient in nutrients and often consumed in isolation without diversification in the diet.

“Sorghum is another cereal crop that is climate-smart, drought-resistant and suited in South Africa’s arid and semi-arid areas, while it offers good nutritional value. However, most consumers are not familiar with the crop except for its application as an instant porridge.  Nixtamalisation is a process that could benefit consumers as maize and sorghum could be transformed into nutritious, safe meals directly from the farm to the fork,” explains Dr Du Toit.

Home-grown dried whole maize kernels, she continues, could be converted into safe and delicious meals in homes using basic equipment as it is widely and effectively done in Mexico by rural women. The research will determine if consumers would accept the process of nixtamalisation, whether the products would be acceptable, and if the nutritional value would be comparable to commercial products.

Some of the news consumer-acceptable products already developed, include maize chips, dehydrated phutu pap, and corndogs. Currently, the team is working on maize-milk, maize-milk frozen dessert and a custard tart. Maize products have the advantage of being lactose- and gluten-free and thus would appeal to consumers of plant-based products.

Societal impact

Dr Du Toit says she is excited about the societal impact this project will have on communities and the country and is hopeful that they will be able to influence policymakers and the industry to provide more nutritious staples that could be “game-changers” for the sake of society. She is looking forward to collaborating with DALRRD, the ARC and the grain industry to ensure that partnerships are strengthened and new opportunities are created for the staff and students.

Prof Wilna Oldewage-Theron, a Professor of Nutrition in the College of Human Sciences at Texas Tech University, will join the research chair next year as the co-leader. She has experience in community nutrition research in Africa, and her research interests include the factors contributing to household food insecurity and malnutrition in resource-poor communities. She will be focused on the nutritional benefits of soy for human health.

Prof Maryke Labuschagne, who is leading the NRF SARChI Chair in Diseases and Quality of Field Crops and who is passionate about impacting malnutrition, has been appointed as mentor for the chair.

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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