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UFS students honoured at 2024 Women in Science Awards

23 August 2024 | Story André Damons | Photo Supplied

Thandokuhle Gama, Dr Glen Tylor and Anele Mthembu — Winners: Thandokuhle Gama (left) and Anele Mthembu (right), who were honoured with the DSI-Esther Mahlangu Master's Fellowship at the 2024 SAWiSA, with Dr Glen Taylor, Senior Director: Directorate Research Development (DRD), UFS.

Two postgraduate students from the University of the Free State (UFS) were honoured at this year’s Women in Science Awards (SAWiSA) hosted by the Department of Science and Innovation (DSI).

Thandokuhle Gama, a Master of Medical Science student with specialisation in Pharmacology, and Anele Mthembu, who is working on her master’s degree in Disaster Management in the Disaster Management Training and Education Centre for Africa (DIMTEC), are both recipients of the DSI-Esther Mahlangu Master's Fellowships.

This fellowship is awarded to women scientists and researchers who are pursuing their master’s or doctoral studies and already hold scholarships from the National Research Foundation or other DSI agencies. The fellowships for Gama and Mthembu are worth R75 000 each and can be used towards their tuition fees or to enhance academic programmes by covering the costs of attending conferences or specialised research materials and equipment required to complete their degrees.

Honouring Dr Esther Mahlangu

The prestigious 2024 SAWiSA, which honour the exceptional contributions of women to science, technology, engineering, mathematics and innovation (STEMI) in South Africa, took place on 15 August 2024 in Mbombela. The theme was “Transition towards an Innovation Economy: The Role of Women Leaders in STEM”.

This year, the awards honoured world-renowned artist, Dr Esther Mahlangu, by renaming this year's master's and doctoral fellowships the DSI-Esther Mahlangu Fellowships.

“I feel honoured and grateful for the recognition, although it's been difficult to process what it actually means. It has been an overwhelming experience. It came as a surprise, because when I applied, I was not sure what to expect because these are national awards with many other applicants,” says Gama.

She was nominated by Innocensia Mangoato, lecturer in the UFS Department of Pharmacology and a previous winner at the awards. Gama is doing research on medicinal plants that are used in traditional medicine to treat diabetes.

“Winning this award means that my work thus far is being recognised. It is all through God’s grace. I'm also grateful to everyone who has contributed towards my journey: my family, teachers, mentors and sponsors, and everyone else. It will allow me to continue to advance research in the field of diabetes treatment using traditional medicines or medicinal plants.”

Bettering lives

Mthembu, who was nominated by her mentor, Dr Tlou Daisy Raphela-Masuku, a lecturer at DIMTEC, says it is a fantastic feeling winning this award. “Before the awards, Dr Raphela-Masuku and I dreamt I could win the SAWiSA. But before then, I was surprised and grateful for being acknowledged by DSI as a finalist; I focused on being a DSI finalist, and that winning would be a bonus,” she says.

She continues: “It means a lot to me to win the DSI Master’s Fellowship, as it is a testimony of God’s grace in my life. It is the destiny for helpers God has placed in my life, including my mentor, supervisor, and the DIMTEC postgraduate school. We all won!”

Mthembu is working her master’s thesis on the integration of risk-informed development (RID) and nature-based solutions (NbS) into sustainable human settlements in eThekwini Municipality, KwaZulu-Natal.

“The overarching aim is to evaluate the integration of both these concepts into human settlements’ strategic planning to offer eThekwini Municipality innovative and ecosystem-based approaches to achieving sustainable and resilient human settlements and achieving Sustainable Development Goal (SDG) 11 on building resilient cities.

“I hope to publish my findings and contextualise the enabling environments for RID (EE4RID) Framework in eThekwini Municipality so they can make risk-informed decisions on development and human settlements to achieve SDG 11,” explains Mthembu.

Gama says the aim with her research is to determine if these medicinal plants can treat diabetes by stimulating stem cells to differentiate and become insulin-producing cells. She hopes that through this research diabetes treatment can advance from a level where it is being continuously managed, to a level where we can cure the disease.

News Archive

Research eradicates bacteria from avocado facility

2017-01-17

Listeria monocytogenes as seen under an electron
microscope. The photo was taken with a transmission
electron microscope at the microscopy unit of the UFS.
Bacteriophages (lollipop-like structures) can be seen
next to the bacterial cells.
Photo: Supplied

“The aim of my project was to identify and characterise the contamination problem in an avocado-processing facility and then to find a solution,” said Dr Amy Strydom, postdoctoral fellow in the Department of Microbial Biochemical and Food Biotechnology at the University of the Free State (UFS).

Her PhD, “Control of Listeria monocytogenes in an Avocado-processing Facility”, aimed to identify and characterise the contamination problem in a facility where avocados were processed into guacamole. Dr Strydom completed her MSc in food science in 2009 at Stellenbosch University and this was the catalyst for her starting her PhD in microbiology in 2012 at the UFS. The research was conducted over a period of four years and she graduated in 2016. The research project was funded by the National Research Foundation.

The opportunity to work closely with the food industry further motivated Dr Strydom to conduct her research. The research has made a significant contribution to a food producer (avocado facility) that will sell products that are not contaminated with any pathogens. The public will then buy food that is safe for human consumption.

What is Listeria monocytogenes?

Listeria monocytogenes is a food-borne pathogenic bacterium. When a food product is contaminated with L. monocytogenes, it will not be altered in ways that are obvious to the consumer, such as taste and smell. When ingested, however, it can cause a wide range of illnesses in people with impaired immune systems. “Risk groups include newborn babies, the elderly, and people suffering from diseases that weaken their immune systems,” Dr Strydom said. The processing adjustments based on her findings resulted in decreased numbers of Listeria in the facility.

The bacteria can also survive and grow at refrigeration temperatures, making them dangerous food pathogens, organisms which can cause illnesses [in humans]. Dr Strydom worked closely with the facility and developed an in-house monitoring system by means of which the facility could test their products and the processing environment. She also evaluated bacteriophages as a biological control agent in the processing facility. Bacteriophages are viruses that can only infect specific strains of bacteria. Despite bacteriophage products specifically intended for the use of controlling L. monocytogenes being commercially available in the food industry, Dr Strydom found that only 26% of the L. monocytogenes population in the facility was destroyed by the ListexP100TM product. “I concluded that the genetic diversity of the bacteria in the facility was too high and that the bacteriophages could not be used as a control measure. However, there is much we do not understand about bacteriophages, and with a few adjustments, we might be able to use them in the food industry.”

Microbiological and molecular characterisation of L. monocytogenes

The bacteria were isolated and purified using basic microbiological culturing. Characterisation was done based on specific genes present in the bacterial genome. “I amplified these genes with polymerase chain reaction (PCR), using various primers targeting these specific genes,” Dr Strydom said. Some amplification results were analysed with a subsequent restriction digestion where the genes were cut in specific areas with enzymes to create fragments. The lengths of these fragments can be used to differentiate between strains. “I also compared the whole genomes of some of the bacterial strains.” The bacteriophages were then isolated from waste water samples at the facility using the isolated bacterial strains. “However, I was not able to isolate a bacteriophage that could infect the bacteria in the facility.

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