Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Funding of R8.7million for skills development in manufacturing and teacher training signed over to UFS

2017-06-19

Description: MerSETA funding Tags: MerSETA funding

The MerSETA (Skills and Training Authority for Manufacturing, Engineering and Related Industries) signed a Memorandum of Agreement (MOA) with the University of the Free State (UFS) for a grant of approximately R8.7million on 14 June 2017, which will be disbursed over a three-year period.

UFS seeks to bridge the skills gap
As a response to the need for skills development in the manufacturing, engineering and related industries sector, and as an institution of higher learning optimally placed to serve the population of central South Africa, the UFS proposed a partnership with MerSETA to address challenges in the sector. The interventions that MerSETA will fund include training for 600 vocational teachers, research and development of a green building mechanical index, in-service training for 60 IT Teachers and microbotics classes for 100 students.

The CEO of MerSETA, and UFS alumnus Dr Raymond Patel, said the funding for rare skills such as in science and engineering are of great importance for the country. The ability to train teachers and to upskill them will yield great results for the economy as a whole. Rector and Vice-Chancellor Prof Francis Petersen said the UFS partnership with SETAs and with MerSETA in particular should be mutually beneficial, and went a long way in integrating first-generation university students to be better-prepared for university studies.

Collaboration and support key within university departments
The delegates visited the Departments of Education and Engineering Sciences on the Bloemfontein Campus, where they met project leaders Louis Lagrange from the Faculty of Natural and Agricultural Sciences, Dr Nixon Teis, Faculty of Education, and Pat Lamusse, Institutional Advancement. Present at the signing ceremony were members of the Rectorate, the Acting Dean of the faculty of Education, Prof Loyiso Jita, and Dean of the Faculty of Natural and Agricultural Sciences, Prof Danie Vermeulen, as well as researchers who will be working on the green building mechanical use index and other MerSETA representatives.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept