Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Prof Prakash Naidoo appointed as Vice-Rector: Operations

2017-09-13

Prof Prakash Naidoo has been appointed
as Vice-Rector: Operations
Photo: Stephen Collet

The Council of the University of the Free State (UFS) approved the appointment of Prof Prakash Naidoo as Vice-Rector: Operations, during its quarterly meeting held on the South Campus in Bloemfontein on 8 September 2017.

Prof Naidoo is a former Deputy Vice-Chancellor: Resources and Planning at the Vaal University of Technology (VUT). He has also been the Executive Dean: Faculty of Management Sciences at VUT. Prior to this, he was a lecturer in the Department of Accounting at the Durban University of Technology (DUT), and Vice-Dean and Acting Dean of the Faculty of Commerce at DUT.
“Prof Naidoo is a seasoned senior manager and an excellent appointment in this vital position. He understands the higher-education sector, and the Council is satisfied by the quality and extent of experience which he will bring to the position,” said Mr Willem Louw, Chairperson of the UFS Council.

He holds a PhD in Management Accounting, MComm in Management Accounting, Honours in Accounting, Honours in Economics, BComm (Acc), and a University Diploma in Education.

Prof Naidoo is a registered professional accountant with the South African Institute of Professional Accountants (SAIPA), an associate of the Chartered Institute of Business Management (CIBM), and an Internationally Certified Fraud Examiner (ACFE). He was also an international associate of the American Institute of Certified Public Accountants (AICPA).
He served as member and chairperson on various boards and forums, including the Investment Committee of the National Tertiary Retirement Fund (NTRF); Audit Committee of the National Institute on Higher Education in Mpumalanga (NIHE); Audit Committee of the Higher Education Purchasing Consortium (PURCO), and other task teams in higher education. He also served as a former director of ACFE (SA Chapter), where he received a commendation for his work in fighting fraud and corruption in the country. He has written and published numerous papers, supervised research, presented papers at conferences, and published one book.
Prof Naidoo is currently the Campus Principal of the university’s Qwaqwa Campus. He will start in the new position as from 1 January 2018, following the subsequent retirement of Prof Nicky Morgan, current Vice-Rector: Operations at the end of December 2017.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept