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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS School of Nursing opens new frontiers at 40
2009-11-16

The opening of the virtual facility of the School of Nursing at the University of the Free State (UFS) and a gala dinner to celebrate the School’s 40th year of existence took place on the Main Campus in Bloemfontein this week. At the opening were, among others, from the left: Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS; Dr Oluseyi Oyedele and Ms Viona Munjeri, both from The Atlantic Philanthropies; and Prof. Anita van der Merwe, Head of the School of Nursing at the UFS.
Photo: Leatitia Pienaar

All eyes in the nursing profession in South Africa were turned to the University of the Free State (UFS) when the School of Nursing opened a state-of-the-art virtual health training and learning facility and celebrated its 40th year of existence with a gala dinner on the Main Campus in Bloemfontein this week.

The lustrous events were attended by dignitaries from all spheres of the health-care fraternity in South Africa.

The new virtual facility, The Space, is made possible by a grant of R16 million from The Atlantic Philanthropies and R1 million from the UFS. The Atlantic Philanthropies organisation is an international philanthropic organisation that is going to inject R70 million into nursing in South African over the next four years. The initiative will enhance nursing education and step up the quality of health-care delivery in South Africa. Four major grants were made to universities in South Africa, of which the UFS is one.

With the facility at the UFS School of Nursing, nursing education is propelled into the future. Prof. Anita van der Merwe, Head of the School of Nursing, says, “The virtual learning facility is a very new way of thinking and teaching. At the moment, theory and practice are separated, as theory is often taught in the mornings, followed by practical settings later in the day. Learner nurses then also go to clinical facilities for their practicals where the quality of care is declining and human resources are a problem.

“We believe that with new technologies such as e-learning and high-tech computer-mediated equipment we can use the ‘virtual world’ to bridge the theory-practice gap in the same location.”

Prof. Van der Merwe says the project is essentially about transformation: taking a stand against stagnation in nursing education and practice and daring to be different.

In the new virtual facility nurses will have the best of three worlds – the expertise of the facilitator/educator, simulation technology, and a vast selection of on-line and off-line software, exposing them to blogs, broadcasting and enhancing computer literacy. This will attract both the new “millennial” generation, which tends to be technologically competent, as well as the older learner because of the unthreatening learning environment.

The core space will accommodate 40 to 60 students and is designed to encourage informal, collaborative learning and practice simultaneously. It will have a demarcated area for “patients” (such as advanced adult and baby patient simulators) and a “clinic space” allowing for role play.

At the gala dinner, Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS commended nurses in South Africa for their caring role, but also expressed his concern that South African has lost its deep sense of care. South Africa is at a critical point and the country can be changed if a deep sense of care can be embedded again.

About forty nursing educators from all over South Africa attended an exploratory workshop in the facility today and the last meeting of the Forum of University Deans in South Africa (FUNDISA) also coincided with the festivities at the School of Nursing.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
13 November 2009
 

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